期刊
NANOMATERIALS
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nano12071214
关键词
engineered nanoparticles; protein; protein folding; misfolding; aggregation; protein corona; molecular chaperones; nanochaperones
类别
资金
- Council of Scientific and Industrial Research, India [HCP-031]
Engineered nanoparticles interact with proteins, potentially leading to changes in protein structure and function, with implications for the therapeutic potential in protein misfolding diseases.
Engineered nanoparticles (ENPs) are artificially synthesized particles with unique physicochemical properties. ENPs are being extensively used in several consumer items, elevating the probability of ENP exposure to biological systems. ENPs interact with various biomolecules like lipids, proteins, nucleic acids, where proteins are most susceptible. The ENP-protein interactions are mostly studied for corona formation and its effect on the bio-reactivity of ENPs, however, an in-depth understanding of subsequent interactive effects on proteins, such as alterations in their structure, conformation, free energy, and folding is still required. The present review focuses on ENP-protein interactions and the subsequent effects on protein structure and function followed by the therapeutic potential of ENPs for protein misfolding diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据