期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 105, 期 2, 页码 531-538出版社
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.35929
关键词
surface modification; polyurethane; polydopamine; antibacterial; antifouling
资金
- The Applied Basic Research Programs Foundation of Sichuan Province [2015JY0126]
- The Fundamental Research Funds for the Central Universities, Southwest University for Nationalities [2016NGJPY04]
Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO3 was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag+ ions were reduced in situ into metallic silver nanoparticles by the bridge of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1H, 1H, 2H, 2H-perfluorodecanethiol (CF3(CF2)(7)CH2CH2SH, F-SH) was attached on the PDA coating via the Michael addition reaction. The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 531-538, 2017.
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