期刊
NANOMATERIALS
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/nano12101735
关键词
coronaviruses; nanotechnology; engineered nanomaterials; environmental health and safety
类别
资金
- National Science Foundation [2031785]
- British Society for Antimicrobial Chemotherapy [BSAC-COVID-81]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [2031785] Funding Source: National Science Foundation
This study developed an antimicrobial platform based on engineered water nanostructures (EWNS) using nanotechnology, which effectively inactivated the human coronavirus 229E (a surrogate of SARS-CoV-2) within 30 seconds, demonstrating its potential as a technology against SARS-CoV-2.
The continuing cases of COVID-19 due to emerging strains of the SARS-CoV-2 virus underscore the urgent need to develop effective antiviral technologies. A crucial aspect of reducing transmission of the virus is through environmental disinfection. To this end, a nanotechnology-based antimicrobial platform utilizing engineered water nanostructures (EWNS) was utilized to challenge the human coronavirus 229E (HCoV-229E), a surrogate of SARS-CoV-2, on surfaces. The EWNS were synthesized using electrospray and ionization of aqueous solutions of antimicrobials, had a size in the nanoscale, and contained both antimicrobial agents and reactive oxygen species (ROS). Various EWNS were synthesized using single active ingredients (AI) as well as their combinations. The results of EWNS treatment indicate that EWNS produced with a cocktail of hydrogen peroxide, citric acid, lysozyme, nisin, and triethylene glycol was able to inactivate 3.8 logs of HCoV-229E, in 30 s of treatment. The delivered dose of antimicrobials to the surface was measured to be in pico to nanograms. These results indicate the efficacy of EWNS technology as a nano-carrier for delivering a minuscule dose while inactivating HCoV-229E, making this an attractive technology against SARS-CoV-2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据