期刊
NANOMATERIALS
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/nano12111874
关键词
dual-crosslinked hydrogel; glycol chitosan; bioactive glass nanoparticles; amino functionalization; strength and elasticity
类别
资金
- National Natural Science Foundation of China [81972065]
This study prepared mesoporous bioactive glass nanoparticles with high specific surface area and further modified their surfaces to produce three kinds of amino-functionalized bioactive glass nanoparticles. These nanoparticles were then crosslinked with glycol chitosan to construct ABG/GCH hydrogels, which showed strong and elastic features. The optimized hydrogels were injectable with tunable gelation time and supported cell growth and matrix deposition.
Mesoporous bioactive glass (BG) nanoparticles (NPs) with a high specific surface area were prepared. The surfaces of BG NPs were further modified using an amino-containing compound or synthesized precursors to produce three kinds of amino-functionalized bioactive glass (ABG) NPs via devised synthetic routes. The achieved ABG NPs possessed various spacer lengths with free amino groups anchored at the end of the spacer. These ABG NPs were then combined with glycol chitosan (GCH) to construct single- or dual-crosslinked ABG/GCH composite hydrogels using genipin (GN) alone as a single crosslinker or a combination of GN and poly(ethylene glycol) diglycidyl ether (PEGDE) as dual crosslinkers. The spacer length of ABG NPs was found to impose significant effects on the strength and elasticity of GN-crosslinked ABG/GCH hydrogels. After being dually crosslinked with GN and PEGDE, the elastic modulus of some dual-crosslinked ABG/GCH hydrogels reached around 6.9 kPa or higher with their yielding strains larger than 60%, indicative of their strong and elastic features. The optimally achieved ABG/GCH hydrogels were injectable with tunable gelation time, and also able to support the growth of seeded MC3T3-E1 cells and specific matrix deposition. These results suggest that the dual-crosslinked ABG/GCH hydrogels have the potential for some applications in tissue engineering.
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