Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial

Review Clinical Neurology

Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials

Reza Gharakhanlou et al.

Summary: Exercise training does not have a significant effect on the global or domain-specific cognitive performance in persons with multiple sclerosis. However, exercise volume explains most of the overall heterogeneity in the studies.

MULTIPLE SCLEROSIS JOURNAL (2021)

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Article Neurosciences

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure andPASAT-3 performance in multiple sclerosis

Dewen Meng et al.

Summary: The study explores the effective connectivity of the dorsolateral-prefrontal circuit in people with multiple sclerosis and its association with cognitive function. Reduced effective connectivity in this circuit is linked to more severe cognitive dysfunction in MS patients. Additionally, the study identifies the dorsolateral prefrontal circuit as a potential target for therapeutic strategies aimed at improving cognition in MS patients.

HUMAN BRAIN MAPPING (2021)

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Article Clinical Neurology

Efficacy of high-intensity aerobic exercise on cognitive performance in people with multiple sclerosis: A randomized controlled trial

Martin Langeskov-Christensen et al.

Summary: In people with multiple sclerosis, 24 weeks of progressive aerobic exercise did not have an impact on cognitive performance overall, but may have improved processing speed in the subgroup with cognitive impairment.

MULTIPLE SCLEROSIS JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Exercise-Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes

Ricardo Augusto Leoni De Sousa et al.

Summary: Type 2 diabetes mellitus is a metabolic disorder associated with insulin resistance and hyperglycemia, which can negatively impact the cardiovascular system and mental health. Lifestyle modifications and physical exercise training are essential in preventing T2DM development and improving associated complications. Exercise, from aerobic to resistance training, has been shown to have beneficial effects on cardiovascular and mental health in T2DM patients, with the myokine irisin being a relevant mechanism of action.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Rehabilitation

Is Aerobic or Resistance Training the Most Effective Exercise Modality for Improving Lower Extremity Physical Function and Perceived Fatigue in People With Multiple Sclerosis? A Systematic Review and Meta-analysis

Laurits Taul-Madsen et al.

Summary: This systematic review compared the effectiveness of aerobic training (AT) and resistance training (RT) in improving lower limb physical function and perceived fatigue in persons with multiple sclerosis (PwMS), finding them equally effective in these outcomes. More head-to-head exercise modality studies are warranted in the future.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2021)

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Review Neurosciences

Effects of Exercise Training on Neurotrophic Factors and Subsequent Neuroprotection in Persons with Multiple Sclerosis-A Systematic Review and Meta-Analysis

Mette D. Diechmann et al.

Summary: This study systematically reviewed the effects of acute and chronic exercise on neurotrophic factors in individuals with multiple sclerosis, finding that exercise can improve chronic levels of neurotrophic factors, especially brain-derived neurotrophic factor (BDNF).

BRAIN SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis

Augustine Joshua Devasahayam et al.

Summary: The study found that individuals with higher fitness levels in progressive MS tend to show a shift towards a repair phenotype, with higher levels of IL-6. Progressive MS patients had significantly lower maximal oxygen consumption, and higher (V)over dotO(2max) was associated with a shift in the balance of blood biomarkers towards a repair phenotype from inflammation.

BIOMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease

Guilherme B. de Freitas et al.

JOURNAL OF NEUROCHEMISTRY (2020)

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Article Clinical Neurology

Exercise and lifestyle physical activity recommendations for people with multiple sclerosis throughout the disease course

Rosalind Kalb et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

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Article Clinical Neurology

Combined exercise training improves cognitive functions in multiple sclerosis patients with cognitive impairment: A single-blinded randomized controlled trial

Cagla Ozkul et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

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Review Medicine, General & Internal

Impact of Exercise on Immunometabolism in Multiple Sclerosis

Remsha Afzal et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Sport Sciences

Effect of High-Intensity Exercise on Multiple Sclerosis Function and Phosphorous Magnetic Resonance Spectroscopy Outcomes

Anna Orban et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2019)

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Review Endocrinology & Metabolism

Physical activity and muscle-brain crosstalk

Bente Klarlund Pedersen

NATURE REVIEWS ENDOCRINOLOGY (2019)

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Article Cell Biology

Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

Kexin Wang et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Multidisciplinary Sciences

BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle

Julien Delezie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Genetics & Heredity

Physical Activity and Brain Health

Carlo Maria Di Liegro et al.

GENES (2019)

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Review Clinical Neurology

Exercise as Medicine in Multiple Sclerosis-Time for a Paradigm Shift: Preventive, Symptomatic, and Disease-Modifying Aspects and Perspectives

Ulrik Dalgas et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

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Article Biochemistry & Molecular Biology

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

Mychael V. Lourenco et al.

NATURE MEDICINE (2019)

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Editorial Material Clinical Neurology

What is the meaning of PASAT rejection in multiple sclerosis?

Ana Cortes-Martinez et al.

ACTA NEUROLOGICA SCANDINAVICA (2019)

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Article Geriatrics & Gerontology

Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women

Ji-Hyeon Kim et al.

EXPERIMENTAL GERONTOLOGY (2018)

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Article Immunology

Effect of combined exercise training on serum brain-derived neurotrophic factor, suppressors of cytokine signaling 1 and 3 in patients with multiple sclerosis

C. Ozkul et al.

JOURNAL OF NEUROIMMUNOLOGY (2018)

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Article Immunology

Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population

Wen-Jun Tu et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Medicine, General & Internal

Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanish cross-sectional study

Juan J. Fernandez-Munoz et al.

BMJ OPEN (2018)

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Article Cell Biology

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes

Kexin Wang et al.

MEDIATORS OF INFLAMMATION (2018)

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Review Medicine, General & Internal

The Role of Irisin in Alzheimer's Disease

Oh Yoen Kim et al.

JOURNAL OF CLINICAL MEDICINE (2018)

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Article Clinical Neurology

Exercise training effects on memory and hippocampal viscoelasticity in multiple sclerosis: a novel application of magnetic resonance elastography

Brian M. Sandroff et al.

NEURORADIOLOGY (2017)

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Review Psychiatry

Exercise effects on depression: Possible neural mechanisms

Swathi Gujral et al.

GENERAL HOSPITAL PSYCHIATRY (2017)

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Article Orthopedics

Different types of exercise in Multiple Sclerosis: Aerobic exercise or Pilates, a single-blind clinical study

Bilge Kara et al.

JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION (2017)

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Article Neurosciences

REGULAR EXERCISE PROMOTES MEMORY FUNCTION AND ENHANCES HIPPOCAMPAL NEUROPLASTICITY IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE

Tae-Woon Kim et al.

NEUROSCIENCE (2017)

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Review Public, Environmental & Occupational Health

Moderators of Exercise Effects on Depressive Symptoms in Multiple Sclerosis: A Meta-regression

Matthew P. Herring et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2017)

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Article Endocrinology & Metabolism

Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life

Motahare Mokhtarzade et al.

ENDOCRINE (2017)

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Article Neurosciences

Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

Mohammad Jodeiri Farshbaf et al.

NEUROMOLECULAR MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Irisin ameliorates depressive-like behaviors in rats by regulating energy metabolism

Sisi Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Article Immunology

Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators

Helcio Alvarenga-Filho et al.

JOURNAL OF NEUROIMMUNOLOGY (2016)

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Article Neurosciences

Irisin: A myokine with locomotor activity

Weizhen Zhang et al.

NEUROSCIENCE LETTERS (2015)

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Article Endocrinology & Metabolism

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

Milan K. Piya et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

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Article Clinical Neurology

Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial

S. Briken et al.

MULTIPLE SCLEROSIS JOURNAL (2014)

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Article Cell Biology

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

Christiane D. Wrann et al.

CELL METABOLISM (2013)

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Article Biochemistry & Molecular Biology

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer IMPLICATIONS FOR RECEPTOR ACTIVATION

Maria A. Schumacher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Neurosciences

IRISIN-IMMUNOREACTIVITY IN NEURAL AND NON-NEURAL CELLS OF THE RODENT

S. L. Dun et al.

NEUROSCIENCE (2013)

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Article Multidisciplinary Sciences

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Bostroem et al.

NATURE (2012)

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Article Clinical Neurology

Biological outcome measurements for behavioral interventions in multiple sclerosis

Anja Fischer et al.

Therapeutic Advances in Neurological Disorders (2011)

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Review Medicine, General & Internal

Multiple sclerosis

Alastair Compston et al.

LANCET (2008)

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Article Psychology, Clinical

Is speed of processing or working memory the primary information processing deficit in multiple sclerosis?

J DeLuca et al.

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY (2004)

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Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial

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