期刊
MOLECULAR THERAPY-NUCLEIC ACIDS
卷 28, 期 -, 页码 397-407出版社
CELL PRESS
DOI: 10.1016/j.omtn.2022.03.012
关键词
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资金
- National Natural Science Foundation of China [82072591]
- Key Research and Development Plan (Social Development) of the Science and Technology Department of Jiangsu Province [BE2019760]
- 123 advantageous disciplines and core technologies of the Second Affiliated Hospital of Nanjing Medical University
Long non-coding RNAs (lncRNAs) play a crucial role in tumor angiogenesis and resistance to anti-angiogenic therapy. Understanding their functions and potential clinical applications is important for improving tumor treatment.
It is well known that long non-coding RNAs (lncRNAs) play an important role in the regulation of tumor genesis and development. They can modulate gene expression of transcriptional regulation, epigenetic regulation of chromatin modification, and post-transcriptional regulation, thus influencing the biological behavior of tumors, such as cell proliferation, apoptosis, cell cycle, invasion, and migration. Tumor angiogenesis not only provides nutrients and helps excrete metabolites, but it also opens a pathway for tumor metastasis. Anti-angiogenic therapy has become one of the effective treatment methods for tumor. But its drug resistance leads to the limitation of clinical application. Recent studies have shown that lncRNAs are closely related to tumor angiogenesis and anti-angiogenic therapy resistance, which provides a new direction for tumor research. lncRNAs are expected to be new targets for tumor therapy. For the first time to our knowledge, this paper reviews advancement of lncRNAs in tumor angiogenesis and antiangiogenic therapy resistance and further discusses their potential clinical application.
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