期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 104, 期 4, 页码 879-888出版社
WILEY
DOI: 10.1002/jbm.a.35621
关键词
nanocomposite; hydroxyapatite nanoparticles; hydrogels; tissue engineering; mechanical properties
资金
- NIH [AR066033]
- NSF [CBET-124848]
- Texas AM University
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1264848] Funding Source: National Science Foundation
Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain. In vitro studies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 879-888, 2016.
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