4.6 Article

Chronic Cold Exposure Leads to Daytime Preference in the Circadian Expression of Hepatic Metabolic Genes

期刊

FRONTIERS IN PHYSIOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2022.865627

关键词

circadian rhythm; metabolism; liver; chronic cold; adaption

资金

  1. Shenzhen Science Technology and Innovation Commission [JCYJ20210324094010029, JCYJ20190808155218940]
  2. Yunnan High-level Talent Training Support Program
  3. Special Project for Industrial Technology Leading Talents, 2021, Yunnan Development and Reform Commission
  4. Major Science and Technology Projects of Yunnan Province (digitalization, development and application of biotic resource) [202002AA100007]

向作者/读者索取更多资源

The circadian rhythm allows organisms to adapt to environmental changes through changes in physiology and behavior. This study explores the adaptive response of the circadian rhythm of liver metabolism to chronic cold exposure. The findings suggest that chronic cold exposure does not alter the rhythmic expression of core clock genes in the liver, but rather rewires the expression of clock control genes to optimize liver metabolism.
Circadian control allows organisms to anticipate and adapt to environmental changes through changes in physiology and behavior. The circadian system timing is entrained by cues, such as light, food, and temperature. An ambient temperature dramatically impacts the sleep-wake cycle and metabolic rhythmicity. As endotherms, mammals rely on tissues such as the liver to provide fuel for thermogenesis to maintain body temperature. The adaptive response of the circadian rhythm of liver metabolism to chronic cold exposure remains largely unexplored. Here, we investigated the circadian rhythm adaptation of hepatic metabolism in response to environmental cold stress using a mouse model of chronic cold exposure. We analyzed metabolites and transcripts of mouse livers at 24 h and found that long-term low-temperature exposure resulted in a synergistic and phase synchronization of transcriptional rhythms of many genes associated with metabolic pathways. Notably, transcription peaked in the early light phase when the body temperature was relatively low. Our results suggest that chronic cold does not alter the rhythmic expression of essential core clock genes in the liver, so the rewiring of clock control gene expression is another mechanism that optimizes the circadian rhythm of liver metabolism to meet the energy requirements of animal thermogenesis.

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