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Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice
Mathieu Darsigny et al.
PLOS ONE (2009)
Defective jejunal and colonic salt absorption and alteredNa(+)/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice
N. Broere et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2009)
Suppression of Na+/H+ exchanger isoform-3 in human inflammatory bowel disease: Lack of reversal by 5 '-aminosalicylate treatment
Iqbal Siddique et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2009)
Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function
Adam J. Moeser et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8)
Hua Xu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2008)
The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins
Boyoung Cha et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2008)
Down-regulated in Adenoma Cl/HCO3 Exchanger Couples With Na/H Exchanger 3 for NaCl Absorption in Murine Small Intestine
Nancy M. Walker et al.
GASTROENTEROLOGY (2008)
IRBIT, Inositol 1,4,5-Triphosphate (IP3) Receptor-binding Protein Released with IP3, Binds Na+/H+ Exchanger NHE3 and Activates NHE3 Activity in Response to Calcium
Peijian He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3
Rafiquel Sarker et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression
Jennifer S. Fang et al.
SEMINARS IN CANCER BIOLOGY (2008)
Effect of NHE1 antisense gene transfection on the biological behavior of SGC-7901 human gastric carcinoma cells
Hai-Feng Liu et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells
Ana Rosa Beltran et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Dilated intercellular spaces in gastroesophageal reflux disease patients and the changes of intercellular spaces after omeprazole treatment
Xue Yan et al.
CHINESE MEDICAL JOURNAL (2008)
Inhibition of TRPP3 channel by amiloride and analogs
Xiao-Qing Dai et al.
MOLECULAR PHARMACOLOGY (2007)
Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice
Mireya Gonzalez-Begne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues
Helle Hasager Damkier et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum
Sandeep B. Subramanya et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)
Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site
Ian Pearse et al.
BIOCHEMICAL JOURNAL (2007)
Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells
Jianning Zhang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Glucose-induced cytosolic pH changes in β-cells and insulin secretion are not causally related -: Studies in islets lacking the Na+/H+ exchanger NHE1
Patrick Stiernet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular mechanism of rat NHE3 gene promoter regulation by sodium butyrate
Pawel R. Kiela et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells
Ping Hua et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)
Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-γ/TNF-α
Md. Ruhul Amin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)
Regulatory binding partners and complexes of NHE3
Mark Donowitz et al.
PHYSIOLOGICAL REVIEWS (2007)
NHE8 mediates amiloride-sensitive Na+/H+ exchange across mosquito Malpighian tubules and catalyzes Na+ and K+ transport in reconstituted proteoliposomes
Wanyoike Kang'ethe et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO-3 exchanger in the upper villous epithelium of the murine duodenum
Janet E. Simpson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)
Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3
R. Todd Alexander et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells
Oliver Bachmann et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)
Epithelial sodium channel inhibition in cardiovascular disease - A potential role for amiloride
Justin Teiwes et al.
AMERICAN JOURNAL OF HYPERTENSION (2007)
The emerging role of PDZ adapter proteins for regulation of intestinal ion transport
G. Lamprecht et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
IFN-γ and TNF-α regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1
Md. Ruhul Amin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice
Yanfang Guan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1
J Malakooti et al.
BIOCHEMICAL JOURNAL (2006)
Role of the Na+/H+ exchanger NHE1 in cell migration
C. Stock et al.
ACTA PHYSIOLOGICA (2006)
Pharmacological profile of KR-33028, a highly selective inhibitor of Na+/H+ exchanger
YS Jung et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death
Stine Falsig Pedersen
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2006)
Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen
N McDaniel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
Rho GTPases dictate the mobility of the Na/H exchanger NHE3 in epithelia:: Role in apical retention and targeting
RT Alexander et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
NHERF family and NHE3 regulation
M Donowitz et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8
H Xu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
Signaling of short-term and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-γ
F Magro et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Amelioration of experimental colitis by Na-H exchanger-1 inhibitor amiloride is associated with reversal of IL-1b and ERK mitogen-activated protein kinase
I Khan et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2005)
cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein
B Cha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger
LR Gawenis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Immunolocalization of NHE8 in rat kidney
S Goyal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure
R Caviglia et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2005)
Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment
C Calabrese et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2005)
Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation
N Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B
H Hayashi et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
Role of serotonin in the pathophysiology of the irritable bowel syndrome
MD Crowell
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
J Orlowski et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Functional characterization of Na+/H+ exchangers in primary cultures of prairie dog gallbladder
SC Narins et al.
JOURNAL OF MEMBRANE BIOLOGY (2004)
Daily cyclic changes in the urinary excretion of 5-hydroxyindoleacetic acid in patients with carcinoid tumors
JM Zuetenhorst et al.
CLINICAL CHEMISTRY (2004)
Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E-coli in human intestinal epithelial cells
G Hecht et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)
The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation
O Bachmann et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
MD Coates et al.
GASTROENTEROLOGY (2004)
Na+/H+ exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes
M Baumgartner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span
K Nehrke
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells
DA Brown et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Kinetic dissection of two distinct proton binding sites in Na+/H+ exchangers by measurement of reverse mode reaction
S Wakabayashi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains
H Lohi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
Renal expression of novel Na+/H+ exchanger isoform NHE8
S Goyal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti-absorptive effect via the VPAC1 receptor in a human enterocyte-like cell line (Caco-2)
CMH Anderson et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands
P Kirchhoff et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Expression, immunolocalization, and functional activity of Na+/H+ exchanger Isoforms in mouse endometrial epithelium
XF Wang et al.
BIOLOGY OF REPRODUCTION (2003)
Activity and protein expression of the Na+/H+ exchanger is reduced in syncytiotrophoblast microvillous plasma membranes isolated from preterm intrauterine growth restriction pregnancies
M Johansson et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9
MO Gut et al.
GASTROENTEROLOGY (2002)
The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase a regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3- exchange to Na+/H+ exchange
G Lamprecht et al.
BIOCHEMISTRY (2002)
Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins
F Thévenod
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
The unique ultrastructure of secretory membranes in gastric parietal cells depends upon the presence of H+, K+-ATPase
ML Milller et al.
CELL AND TISSUE RESEARCH (2002)
Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function
A Lucioni et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Apical Na+/H+ exchange near the base of mouse colonic crypts
JS Chu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model
A Bagorda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Intestinal NaCl transport in NHE2 and NHE3 knockout mice
LR Gawenis et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum
P Jacob et al.
GASTROENTEROLOGY (2002)
Loss of the NHE2 Na+/H+ exchanger has no apparent effect on diarrheal state of NHE3-deficient mice
C Ledoussal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Half-lives of plasma membrane Na+/H+ exchangers NHE1-3:: plasma membrane NHE2 has a rapid rate of degradation
ME Cavet et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)
Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2
C Ledoussal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)
Regulation of the rat NHE3 gene promoter by sodium butyrate
PR Kiela et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Epidermal growth factor regulation of rat NHE2 gene expression
H Xu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)
Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer
AR Black et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2001)
Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex
EJ Weinman et al.
KIDNEY INTERNATIONAL (2001)
Differential expression and regulation of Na+/H+ exchanger isoforms in rabbit parietal and mucous cells
H Rossmann et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles -: Dependence on protein kinase A-mediated NHE3 phosphorylation
MC Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient mice
K Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Human duodenal mucosal brush border Na+/H+ exchangers NHE2 and NHE3 alter net bicarbonate movement
M Repishti et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO-3 salvage mechanisms in model systems and the mouse pancreatic duct
W Ahn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
IFN-γ downregulates expression of Na+/H+ exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells
F Rocha et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)
Transcriptional regulation of rat Na+/H+ exchanger isoform-2 (NHE-2) gene by Sp1 transcription factor
LQ Bai et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)
Immunolocalization of anion exchanger AE2, Na+/H+ exchangers NHE1 and NHE4, and vacuolar type H+-ATPase in rat pancreas
E Roussa et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2001)
SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells
MW Musch et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
The human Na+/H+ exchanger NHE2 gene:: genomic organization and promoter characterization
J Malakooti et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
HCO3- salvage mechanisms in the submandibular gland acinar and duct cells
X Luo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Expression and cell-specific and membrane-specific localization of NHE-3 in the human and guinea pig upper gastrointestinal tract
H Kulaksiz et al.
CELL AND TISSUE RESEARCH (2001)
Congenital sodium diarrhea is an autosomal recessive disorder of sodium/proton exchange but unrelated to known candidate genes
T Müller et al.
GASTROENTEROLOGY (2000)
Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
SJ Reshkin et al.
FASEB JOURNAL (2000)
Acute regulation of Na+/H+ exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis
R Collazo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Role of Na+HCO3- cotransporter NBC1, Na+/H+ exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion
P Jacob et al.
GASTROENTEROLOGY (2000)
Agonist-induced cytoplasmic volume changes in cultured rabbit parietal cells
T Sonnentag et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
Na+-dependent transporters mediate HCO3- salvage across the luminal membrane of the main pancreatic duct
MG Lee et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells
J Praetorius et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
Macula densa Na+/H+ exchange activities mediated by apical NHE2 and basolateral NHE4 isoforms
J Peti-Peterdi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2000)
Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease
E Solcia et al.
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY (2000)
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