4.6 Article

Identification of Genes Reveals the Mechanism of Cell Ferroptosis in Diabetic Nephropathy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

Xue-qi Liu et al.

Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.

ACTA PHARMACOLOGICA SINICA (2022)

Article Multidisciplinary Sciences

Bioinformatics analysis of genes related to iron death in diabetic nephropathy through network and pathway levels based approaches

Yaling Hu et al.

Summary: Iron death affects diabetic nephropathy, and key factors and genes related to diabetic nephropathy were identified through analysis of markers and gene expression differences. These factors and genes may be potential target for therapeutic drugs.

PLOS ONE (2021)

Article Biochemistry & Molecular Biology

Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients

Zhou Zhou et al.

Summary: Our study found that serum CN-1 concentration and activity were highest in patients with diabetic nephropathy (DN), while serum carnosine concentration was lowest. Furthermore, serum CN-1 concentration was positively correlated with uric acid and serum creatinine, and negatively correlated with serum albumin and estimated glomerular filtration rate within the DN group. Additionally, serum CN-1 concentration was positively correlated with various indicators of renal damage, suggesting its importance in the occurrence and progression of DN.

AMINO ACIDS (2021)

Article Urology & Nephrology

MiR-142-3p ameliorates high glucose-induced renal tubular epithelial cell injury by targeting BOD1

Ningmin Zhao et al.

Summary: The study revealed that miR-142-3p has a protective effect on apoptosis and oxidative stress of renal tubular epithelial cells treated with high glucose, by targeting BOD1. This finding might offer novel insights into the role of the miR-142-3p/BOD1 axis in the treatment of DN.

CLINICAL AND EXPERIMENTAL NEPHROLOGY (2021)

Article Medicine, Research & Experimental

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

Qianjin Zhang et al.

Summary: The study revealed that overexpression of Prdx6 can prevent podocyte injury induced by high glucose through modulation of oxidative stress and ferroptosis, providing new insights into the mechanism of diabetic nephropathy.

LIFE SCIENCES (2021)

Article Oncology

Salusin-β participates in high glucose-induced HK-2 cell ferroptosis in a Nrf-2-dependent manner

Wen-Juan Wang et al.

Summary: The study revealed that salusin-beta plays a crucial role in diabetic kidney damage by regulating ferroptosis, with its activity exacerbating abnormal changes induced by high glucose. Furthermore, inactivation of the Nrf-2 signaling pathway by salusin-beta also influences the occurrence of ferroptosis.

MOLECULAR MEDICINE REPORTS (2021)

Article Biochemistry & Molecular Biology

Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy

Shuangwen Li et al.

Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Pharmacology & Pharmacy

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

Yue Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Cell Biology

Nine hub genes as the potential indicator for the clinical outcome of diabetic nephropathy

Xiaoping Song et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Cell Biology

MiR-320a induces diabetic nephropathy via inhibiting MafB

Mengying He et al.

AGING-US (2019)

Article Multidisciplinary Sciences

The single-cell transcriptomic landscape of early human diabetic nephropathy

Parker C. Wilson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Multidisciplinary Sciences

Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy

Francesca Conserva et al.

SCIENTIFIC REPORTS (2019)

Review Biochemistry & Molecular Biology

12/15 lipoxygenase: A crucial enzyme in diverse types of cell death

Qiu-Qi Li et al.

NEUROCHEMISTRY INTERNATIONAL (2018)

Article Pathology

Complement 7 Is Up-Regulated in Human Early Diabetic Kidney Disease

Monica Sircar et al.

AMERICAN JOURNAL OF PATHOLOGY (2018)

Article Cell Biology

Heat stress induces ferroptosis-like cell death in plants

Ayelen Mariana Distefano et al.

JOURNAL OF CELL BIOLOGY (2017)

Review Pharmacology & Pharmacy

Ferroptosis Inhibition: Mechanisms and Opportunities

Jose Pedro Friedmann Angeli et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Pharmacology & Pharmacy

Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death

Lukas Probst et al.

BIOCHEMICAL PHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy

Gladys O. Latunde-Dada

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Article Cell Biology

Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

Review Biochemistry & Molecular Biology

Mammalian lipoxygenases and their biological relevance

Hartmut Kuhn et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)

Editorial Material Oncology

Metabolism and iron signaling in ferroptotic cell death

Minghui Gao et al.

ONCOTARGET (2015)

Review Endocrinology & Metabolism

Inhibition of 12/15-Lipoxygenase Reduces Renal Inflammation and Injury in Streptozotocin-Induced Diabetic Mice

Jessica Faulkner et al.

JOURNAL OF DIABETES & METABOLISM (2015)

Review Cell Biology

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Antonio Ayala et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.