4.7 Review

A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Plant Sciences

A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils.

Ke Yang et al.

Summary: Schisandra chinensis and Schisandra sphenanthera, known as bei-wuweizi and nan-wuweizi in Chinese respectively, are highly similar plants with traditional uses in Chinese medicine for treating various conditions. They have similar chemical compositions and pharmacological activities, with potential drug interactions due to their inhibitory effects on CYP3A and P-gp. Further research is needed to explore their traditional uses and differences for clinical applications.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Chemistry, Analytical

UPLC-MS/MS method for the determination of Lenvatinib in rat plasma and its application to drug-drug interaction studies

Yanjun Cui et al.

Summary: The combination of traditional Chinese medicine preparation Wuzhi capsule (WZC) and multitargeted tyrosine kinase inhibitor Lenvatinib (LEN) may impact the pharmacokinetic parameters of LEN in rats and increase the plasma concentration of LEN. An UPLC-MS/MS method developed in this study serves as a valuable tool for studying drug-drug interactions.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

Article Pharmacology & Pharmacy

Inhibitory Effects of Schisandra Lignans on Cytochrome P450s and Uridine 5′-Diphospho-Glucuronosyl Transferases in Human Liver Microsomes

Hyung-Ju Seo et al.

Summary: The study found that lignans from Schisandra can inhibit the activity of certain cytochrome P450 enzymes, with some glutathione trapping reactive metabolites. This information may help predict potential drug interactions between Schisandra lignans and other drugs mainly metabolized by P450 enzymes.

PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Effects and safety evaluation of Wuzhi Capsules combined with tacrolimus for the treatment of kidney transplantation recipients

Fang Cheng et al.

Summary: Wuzhi capsule can increase tacrolimus concentration without negative effects on renal function and adverse reactions, especially in CYP3A5 expressers.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2021)

Article Integrative & Complementary Medicine

Schisandra sphenanthera: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications

Shiqi Huang et al.

Summary: Schisandra sphenanthera is a medicinal herb with a wide range of bioactivities, including antitumor, anti-oxidant, anti-inflammatory, osteoblastic, immune regulation, neuroprotective, kidney protection, hepatoprotective, and antiviral activities. There is still a need for further studies on resource availability, quality control measures, in-depth in vivo pharmacological study, and clinical application.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Article Oncology

Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp

Ran Fu et al.

Summary: The study showed that co-administration of WZC reduced the clearance and volume distribution of MTX, increased the peak concentration and area under the curve of MTX, while inhibiting the expression of OAT1/3 in the kidney and P-gp in the small intestine. These findings suggest that there is a drug interaction between WZC and MTX, with OAT1/3 and P-gp playing key roles in mediating this interaction.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Review Pharmacology & Pharmacy

Clinically relevant drug interactions between statins and antidepressants

Caterina Palleria et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2020)

Review Food Science & Technology

Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology

Jiri Patocka et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Review Biochemistry & Molecular Biology

Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification

Xiao Chen et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Pharmacology & Pharmacy

Role of vitamin D receptor in the regulation of CYP3A gene expression

Xuan Qin et al.

ACTA PHARMACEUTICA SINICA B (2019)

Review Medicine, Research & Experimental

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

Kandhasamy Sowndhararajan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Biochemistry & Molecular Biology

Tacrolimus - Pharmacokinetic Considerations for Clinicians

Katharina Schuette-Nuetgen et al.

CURRENT DRUG METABOLISM (2018)

Review Pharmacology & Pharmacy

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Palrasu Manikandan et al.

CURRENT DRUG TARGETS (2018)

Article Pharmacology & Pharmacy

Schisandrol B protects against cholestatic liver injury through pregnane X receptors

Hang Zeng et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Biotechnology & Applied Microbiology

Gold nanoparticles for photoacoustic imaging

Wanwan Li et al.

NANOMEDICINE (2015)

Article Pharmacology & Pharmacy

Schisandrin A and B affect subventricular zone neurogenesis in mouse

Yi-Xue Sun et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

Article Medicine, General & Internal

Early- Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Qing Zhou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Pharmacology & Pharmacy

Deoxyschizandrin, a Naturally Occurring Lignan, Is a Specific Probe Substrate of Human Cytochrome P450 3A

Jingjing Wu et al.

DRUG METABOLISM AND DISPOSITION (2014)

Article Plant Sciences

In vivo effect of Schisandrin B on cytochrome P450 enzyme activity

Wei-Liang Li et al.

PHYTOMEDICINE (2013)

Proceedings Paper Materials Science, Ceramics

Improvement of Impaired Memory in Mice by Schisandrin

Yanchun Wang et al.

ADVANCED ENGINEERING MATERIALS III, PTS 1-3 (2013)

Article Pharmacology & Pharmacy

Effects of Traditional Chinese Medicine Wuzhi Capsule on Pharmacokinetics of Tacrolimus in Rats

Hua Wei et al.

DRUG METABOLISM AND DISPOSITION (2013)

Article Pharmacology & Pharmacy

Inhibitory Effects of Continuous Ingestion of Schisandrin A on CYP3A in the Rat

Wei-Liang Li et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)

Article Pharmacology & Pharmacy

A study about drug combination therapy of Schisandra sphenanthera extract and Rapamycin in healthy subjects

Ruidong Li et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2012)

Letter Pharmacology & Pharmacy

Effects of Schisandra sphenanthera extract on the blood concentration of tacrolimus in renal transplant recipients

Hua-Wen Xin et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2011)

Article Pharmacology & Pharmacy

Enhancement of Oral Bioavailability of Paclitaxel after Oral Administration of Schisandrol B in Rats

Jing Jin et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2010)

Article Biochemical Research Methods

Simultaneous LC-MS quantification of 15 lignans in Schisandra chinensis (Turcz.) baill. Fruit

Xinxiu Deng et al.

CHROMATOGRAPHIA (2008)

Article Biochemical Research Methods

LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.

Wei Gu et al.

CHROMATOGRAPHIA (2008)

Review Plant Sciences

Pharmacology of Schisandra chinensis Bail.:: An overview of Russian research and uses in medicine

Alexander Panossian et al.

JOURNAL OF ETHNOPHARMACOLOGY (2008)

Article Pharmacology & Pharmacy

Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers

Hua-Wen Xin et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2007)

Article Pharmacology & Pharmacy

Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract

H Iwata et al.

DRUG METABOLISM AND DISPOSITION (2004)

Article Psychology, Clinical

Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment

A Zourková et al.

JOURNAL OF SEX & MARITAL THERAPY (2002)