4.7 Review

A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities

期刊

FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.816036

关键词

Schisandra sphenanthera; Schisandraceae; lignans; drug-drug interactions; ADME; Schisandra chinensis

资金

  1. Innovative Clinical Research Funding Project [2020YLCYJ-Y25]
  2. Three-year Action Plan for the Development of Traditional Chinese Medicine of Shanghai
  3. Shanghai Municipal Health Commission [ZYCC2019018, 0806, 1016]
  4. Science and Technology Commission of Shanghai Municipality [22S21901900]
  5. National Natural Science Foundation of China [81830109, 81573793]
  6. Shanghai Science and Technology Development Funds [19QB1404500]
  7. [(2021-2023)-0215]

向作者/读者索取更多资源

This review summarized the effects of Wu Wei Zi extract and its major lignan components on cytochrome P450 and P-glycoprotein activities, as well as the absorption, distribution, metabolism, and elimination of the major lignans. The results enhance our understanding of the drug-drug interaction mechanisms involving Wu Wei Zi.
Wu Wei Zi is the dried fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra sphenanthera Rehd. et Wils. (family Magnoliaceae). As a homology of medicine and food, it has been widely used in China for thousands of years, to tonify the kidney, and ameliorate neurological, cardiovascular, liver, and gastrointestinal disorders. As its increasing health benefits and pharmacological value, many literatures have reported that the combination of Wu Wei Zi in patients has led to fluctuations in the blood level of the combined drug. Therefore, it is extremely important to evaluate its safety concern such as drug-drug interactions (DDIs) when patients are under the poly-therapeutic conditions. This review summarized the effects of Wu Wei Zi extract and its major lignan components on cytochrome P450 and P-glycoprotein activities, the change of which could induce metabolic DDIs. Our review also elaborated on the differences of the major lignan components of the two Schisandra species, as well as the absorption, distribution, metabolism, and elimination of the major lignans. In conclusion, these results would enhance our understanding of the DDI mechanisms involving Wu Wei Zi, and may potentially untangle some differing and conflicting results in the future.

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