期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.816036
关键词
Schisandra sphenanthera; Schisandraceae; lignans; drug-drug interactions; ADME; Schisandra chinensis
资金
- Innovative Clinical Research Funding Project [2020YLCYJ-Y25]
- Three-year Action Plan for the Development of Traditional Chinese Medicine of Shanghai
- Shanghai Municipal Health Commission [ZYCC2019018, 0806, 1016]
- Science and Technology Commission of Shanghai Municipality [22S21901900]
- National Natural Science Foundation of China [81830109, 81573793]
- Shanghai Science and Technology Development Funds [19QB1404500]
- [(2021-2023)-0215]
This review summarized the effects of Wu Wei Zi extract and its major lignan components on cytochrome P450 and P-glycoprotein activities, as well as the absorption, distribution, metabolism, and elimination of the major lignans. The results enhance our understanding of the drug-drug interaction mechanisms involving Wu Wei Zi.
Wu Wei Zi is the dried fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra sphenanthera Rehd. et Wils. (family Magnoliaceae). As a homology of medicine and food, it has been widely used in China for thousands of years, to tonify the kidney, and ameliorate neurological, cardiovascular, liver, and gastrointestinal disorders. As its increasing health benefits and pharmacological value, many literatures have reported that the combination of Wu Wei Zi in patients has led to fluctuations in the blood level of the combined drug. Therefore, it is extremely important to evaluate its safety concern such as drug-drug interactions (DDIs) when patients are under the poly-therapeutic conditions. This review summarized the effects of Wu Wei Zi extract and its major lignan components on cytochrome P450 and P-glycoprotein activities, the change of which could induce metabolic DDIs. Our review also elaborated on the differences of the major lignan components of the two Schisandra species, as well as the absorption, distribution, metabolism, and elimination of the major lignans. In conclusion, these results would enhance our understanding of the DDI mechanisms involving Wu Wei Zi, and may potentially untangle some differing and conflicting results in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据