4.7 Article

Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

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Summary: This study demonstrates that agonist-promoted KOR phosphorylation plays important roles in U50,488H-induced tolerance and conditioned place aversion (CPA) in a sex-dependent manner, without affecting acute U50,488H-induced anti-pruritic and hypo-locomotor effects. These results are the first to show sex differences in the effects of GPCR phosphorylation on GPCR-mediated behaviors.

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