4.7 Review

Promising Antioxidative Effect of Berberine in Cardiovascular Diseases

期刊

FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.865353

关键词

Berberine; cardiovascular disease; reactive oxygen species; coronary atherosclerosis; myocardial infarction; reperfusion

资金

  1. National Natural Science Foundation of China [82174349]
  2. CACMS Innovation Fund [CI2021A00919]
  3. National Key Research and Development Program of China [2018YFC1704901, 2018YFC1704900]

向作者/读者索取更多资源

This article summarizes the mechanisms of action of berberine (BBR) in the prevention and treatment of cardiovascular diseases (CVDs). Research has shown that BBR has various pharmacological effects, such as lowering blood sugar, reducing lipid levels, and exerting antioxidant activities. It can protect the myocardium and has therapeutic effects on coronary atherosclerosis, myocardial ischemia/reperfusion, arrhythmias, and heart failure.
Berberine (BBR), an important quaternary benzylisoquinoline alkaloid, has been used in Chinese traditional medicine for over 3,000 years. BBR has been shown in both traditional and modern medicine to have a wide range of pharmacological actions, including hypoglycemic, hypolipidemic, anti-obesity, hepatoprotective, anti-inflammatory, and antioxidant activities. The unregulated reaction chain induced by oxidative stress as a crucial mechanism result in myocardial damage, which is involved in the pathogenesis and progression of many cardiovascular diseases (CVDs). Numerous researches have established that BBR protects myocardium and may be beneficial in the treatment of CVDs. Given that the pivotal role of oxidative stress in CVDs, the pharmacological effects of BBR in the treatment and/or management of CVDs have strongly attracted the attention of scholars. Therefore, this review sums up the prevention and treatment mechanisms of BBR in CVDs from in vitro, in vivo, and finally to the clinical field trials timely. We summarized the antioxidant stress of BBR in the management of coronary atherosclerosis and myocardial ischemia/reperfusion; it also analyzes the pathogenesis of oxidative stress in arrhythmia and heart failure and the therapeutic effects of BBR. In short, BBR is a hopeful drug candidate for the treatment of CVDs, which can intervene in the process of CVDs from multiple angles and different aspects. Therefore, if we want to apply it to the clinic on a large scale, more comprehensive, intensive, and detailed researches are needed to be carried out to clarify the molecular mechanism and targets of BBR.

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