期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.902049
关键词
osteosarcoma; exosome; miRNA; non-coding RNA; biogenesis
资金
- National Natural Science Foundation of China [81902745]
- Hunan Provincial Administration of Traditional Chinese Medicine Project [D2022117]
MiRNAs are non-coding RNA molecules that play important roles in cancer. Recent studies have shown that exosomal miRNAs play crucial roles in tumor initiation and progression, and have potential diagnostic and therapeutic functions.
MiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition via base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies including osteosarcoma. MiRNAs can be transported by exosome, the nano-extracellular vesicle with a diameter of 30-150 nm. Recently, a growing number of studies have demonstrated that exosomal miRNAs play a critical role in tumor initiation and progression, by exerting multiple biological functions including metastasis, angiogenesis, drug resistance and immunosuppression. In this review, we aim to depict the biogenesis of exosomal miRNAs and summarize the potential diagnostic and therapeutic functions of exosomal miRNAs in osteosarcoma.
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