The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review

Mitragynine, is a naturally occurring indole alkaloid that can be isolated from the leaves of a psychoactive medicinal plant. Mitragyna speciosa, also known as kratom, is found to possess promising analgesic effects on mediating the opioid receptors such as mu (MOR), delta (DOR), and kappa (KOR). This alkaloid has therapeutic potential for pain management as it has limited adverse effect compared to a classical opioid, morphine. Mitragynine is frequently regarded to behave like an opioid but possesses milder withdrawal symptoms. The use of this alkaloid as the source of an analgesic candidate has been proven through comprehensive preclinical and clinical studies. The present data have shown that mitragynine is able to bind to opioid receptors, particularly MOR, to exhibit the analgesic effect. Moreover, the chemical and pharmacological aspects of mitragynine and its diastereomers, speciogynine, speciociliatine, and mitraciliatine, are discussed. It is interesting to know how the difference in stereochemical configuration could lead to the difference in the bioactivity of the respective compounds. Hence, in this review, the updated pharmacological and toxicological properties of mitragynine and its diastereomers are discussed to render a comprehensive understanding of the pharmacological properties of mitragynine and its diastereomers based on their structure-activity relationship study.

Automated summary

Mitragynine is a naturally occurring indole alkaloid extracted from the leaves of the medicinal plant Mitragyna speciosa, which shows promising analgesic effects with limited adverse effects compared to morphine. This review discusses the pharmacological and toxicological properties of mitragynine and its diastereomers, speciogynine, speciociliatine, and mitraciliatine, and explores the structure-activity relationship of these compounds.