4.7 Review

Medicinal Cannabis and Central Nervous System Disorders

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Erik B. Oleson et al.

Summary: The mesocorticolimbic dopamine pathway is modulated by the endocannabinoid system and external cannabinoids, which have a long history of use. This review aims to summarize the impact of cannabinoid modulation on dopamine release in investigating motivational or attentional control of behavior. The interaction between dopamine and cannabinoids in motivational and attentional processes requires further research.

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Summary: Memory is a crucial aspect of individuality, with retrieval posing a challenge for patients with memory deficits. The neurotransmitter 5-hydroxytryptamine (5-HT) is involved in memory processes, and activation of 5-HT1A and 5-HT7 receptors has been shown to enhance memory retrieval, making them potential therapeutic targets for improving long-term memory retrieval.

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The Effects of Cannabidiol Oil on Noninvasive Measures of Muscle Damage in Men

Kristen C. Cochrane-Snyman et al.

Summary: The study found that CBD oil had no effect on noninvasive markers of muscle damage, showing no condition-time interaction or main effect of condition. However, there were main effects for time on perceived soreness and hanging joint angle.

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Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

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Anxiety disorders

Brenda W. J. H. Penninx et al.

Summary: Anxiety disorders are the most common group of mental disorders, characterized by excessive fear, anxiety, and avoidance of perceived threats. Risk factors include genetic and environmental influences, with high rates of comorbidity with other mental disorders. Timely and accurate treatment is crucial for reducing the burden of anxiety disorders.

LANCET (2021)

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Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice

Juan Carlos Ledesma et al.

Summary: The study reveals that CBD does not affect the acquisition, expression, and extinction of cocaine addiction, but can prevent priming-induced reinstatement of conditioned place preference during the extinction phase. Additionally, CBD can reduce cocaine-induced hyperactivity and memory deficits, but does not reverse depressive-like symptoms.

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The CANBACK trial: a randomised, controlled clinical trial of oral cannabidiol for people presenting to the emergency department with acute low back pain

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Summary: In the emergency department, single-dose oral CBD is not superior to placebo in relieving acute non-traumatic low back pain. Pain scores, length of stay, use of rescue analgesia, and reported side effects were similar between the two groups.

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Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory pain model

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Summary: The study found no consistent dose-effect relationship of dronabinol on hydromorphone, with analgesia improvement only observed at a specific dosage. The combination of low doses had the lowest abuse risk, while higher doses were associated with increased risk of abuse and adverse events. Opioid responders showed higher subjective effects and abuse risk compared to nonresponders.

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The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: A randomized cross-over clinical trial

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Stacy D'Andre et al.

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Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study

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Amir Garakani et al.

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Safety and Tolerability of Cannabidiol in Parkinson Disease: An Open Label, Dose-Escalation Study

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Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology

Jessica Falco-Walter

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Cannabinoid Augmentation of Exposure-Based Psychotherapy for Obsessive-Compulsive Disorder

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Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control

Megan O'Connell et al.

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Epidemiology of amyotrophic lateral sclerosis: an update of recent literature

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Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice

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Michael G. Erkkinen et al.

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The pharmacokinetics and the pharmacodynamics of cannabinoids

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Alan J. Thompson et al.

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Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

Orrin Devinsky et al.

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Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability

Ziva D. Cooper et al.

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Role of the endocannabinoid system in drug addiction

Jorge Manzanares et al.

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Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Natascia Bruni et al.

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Andrew J. Aschenbrenner et al.

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E. Ray Dorsey et al.

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Pooled analysis of three randomized, double-blind, placebo controlled trials with rimonabant for smoking cessation

Jason D. Robinson et al.

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Prevalence of Parkinson's disease across North America

C. Marras et al.

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Ethan B. Russo

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Cannabidiol reduces ethanol consumption, motivation and relapse in mice

Adrian Viudez-Martinez et al.

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Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients

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Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala

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Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

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Marios Polotis et al.

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In vivo type 1 cannabinoid receptor availability in Alzheimer's disease

Rawaha Ahmad et al.

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Effects of cannabidiol in the treatment of patients with Parkinson's disease: An exploratory double-blind trial

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Adverse Health Effects of Marijuana Use

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Patrick W. Mantyh

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A protocol for the delivery of cannabidiol (CBD) and combined CBD and Δ9-tetrahydrocannabinol (THC) by vaporisation

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PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program

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Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings

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Liposomal drug delivery systems: From concept to clinical applications

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Differential expression and functional role of cannabinoid genes in alcohol users

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Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord

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CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

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MUltiple Sclerosis and Extract of Cannabis: results of the MUSEC trial

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Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo

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?9-tetrahydrocannabinol (?9-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease

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An Evidence-Based Review of Acute and Long-Term Effects of Cannabis Use on Executive Cognitive Functions

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Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

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CB1 Receptor Blockade Decreases Ethanol Intake and Associated Neurochemical Changes in Fawn-Hooded Rats

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Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors

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Smoked cannabis for chronic neuropathic pain: a randomized controlled trial

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Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo

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Functional Expression of Brain Neuronal CB2 Cannabinoid Receptors Are Involved in the Effects of Drugs of Abuse and in Depression

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The role of 5-HT1A receptors in learning and memory

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C. A. Davie

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Therapeutic effects of Δ9-THC and modafinil in a marmoset Parkinson model

Sanneke A. M. van Vliet et al.

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The CB2 cannabinoid receptor controls myeloid progenitor trafficking

Javier Palazuelos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis

C. Collin et al.

EUROPEAN JOURNAL OF NEUROLOGY (2007)

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Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

Javier Fernandez-Ruiz et al.

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Serotonergic mechanisms in amyotrophic lateral sclerosis

Reuven Sandyk

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Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice

Lynsey G. Bilsland et al.

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CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms

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Identification and functional characterization of brainstem cannabinoid CB2 receptors

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Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli

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Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis:: In vivo study using gene-deficient mice

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Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival

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Are oral cannabinoids safe and effective in refractory neuropathic pain?

N Attal et al.

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Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid

C Raman et al.

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Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice

EA McCaw et al.

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The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy

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Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine

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