期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.902459
关键词
cardiotonic steroids (CTS); antitumor; antiviral; neuroprotection; immune regulation
资金
- General Project of National Natural Science Foundation of China [82170284, 81773733]
- Major Project of Heilongjiang Province Applied Technology Research and Development Program [GA18C006]
- Shaoshuaijiebang Project, Strengthening and Efficiency Enhancement of Advantaged and Characteristic Disciplines Project of Harbin Medical University [HMUMIF-21026]
Cardiotonic steroids (CTS) are a group of compounds found in animals and plants. They have traditionally been used to treat cardiovascular diseases, but recent studies have discovered their potential applications in areas such as anti-tumor, anti-virus, neuroprotection, and immune regulation.
Cardiotonic steroids (CTS) are a group of compounds existing in animals and plants. CTS are commonly referred to cardiac glycosides (CGs) which are composed of sugar residues, unsaturated lactone rings and steroid cores. Their traditional mechanism of action is to inhibit sodium-potassium ATPase to strengthen the heart and regulate heart rate, so it is currently widely used in the treatment of cardiovascular diseases such as heart failure and tachyarrhythmia. It is worth noticing that recent studies have found an avalanche of inestimable values of CTS applications in many fields such as anti-tumor, anti-virus, neuroprotection, and immune regulation through multi-molecular mechanisms. Thus, the pharmacological activities and applications of CTS have extensive prospects, which would provide a direction for new drug research and development. Here, we review the potential applications of CTS in cardiovascular system and other systems. We also provide suggestions for new clinical practical strategies of CTS, for many diseases. Four main themes will be discussed, in relation to the impact of CTS, on 1) tumors, 2) viral infections, 3) nervous system diseases and 4) immune-inflammation-related diseases.
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