4.7 Article

Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Food Science & Technology

IRE1 and CaMKKβ pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells

Ya Ma et al.

Summary: MC-LR induces autophagy in ovarian cells and ovarian injury via the IRE1 and CaMKK beta pathways. Inhibition of these pathways can significantly alleviate autophagy and damage induced by MC-LR.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Chemistry, Medicinal

Puerarin inhibits the development of osteoarthritis through antiinflammatory and antimatrix-degrading pathways in osteoarthritis-induced rat model

Tian-wen Ma et al.

Summary: The study showed that puerarin has anti-inflammatory and anti-matrix-degrading effects in a rat osteoarthritis model, reducing cartilage damage, inhibiting inflammatory factors, and promoting cartilage repair.

PHYTOTHERAPY RESEARCH (2021)

Review Cell Biology

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

Linli Zheng et al.

Summary: Osteoarthritis is a degenerative joint disease characterized by low-grade inflammation and high clinical heterogeneity. Changes in chondrocyte metabolism may play a key role in cartilage degeneration and disease progression, with the shift between oxidative phosphorylation and glycolysis being regulated by AMP activated protein kinase and mechanistic target of rapamycin pathways. Understanding chondrocyte metabolism and altered metabolic pathways can provide insights into age-related OA pathophysiology and guide the development of new therapeutic targets.

AGEING RESEARCH REVIEWS (2021)

Review Biochemistry & Molecular Biology

Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies

Maria Teresa Valenti et al.

Summary: Autophagy plays a crucial role in maintaining cartilage homeostasis and preventing premature apoptosis of chondrocytes. Differential expression of autophagomiRNAs has been observed in osteoarthritis and may serve as therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Hip and Knee Osteoarthritis A Review

Jeffrey N. Katz et al.

Summary: Osteoarthritis is a prevalent joint disease that can impact various joints, with risk factors including age, gender, obesity, genetics, and major joint injury. Treatment typically involves exercise, weight management, education, and medication therapy. Advanced cases may require surgical intervention for pain relief and improved function.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Endocrinology & Metabolism

17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway

Runhong Mei et al.

Summary: This study demonstrates that 17β-estradiol induces mitophagy upregulation to protect chondrocytes via the SIRT1-mediated AMPK/mTOR signaling pathway. This protective effect involves the regulation of SIRT1, AMPK, and mTOR expression, leading to improved chondrocyte viability and proliferation.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Biochemistry & Molecular Biology

Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

Maria-Luisa Perez-Lozano et al.

Summary: Osteoarthritis is a complex degenerative disease that disrupts joint homeostasis, leading to inflammation, cartilage degradation, and pain. Studies show that dietary components and natural products have potential for new therapeutic strategies. Current research is focused on natural-product-based treatments for osteoarthritis management.

ANTIOXIDANTS (2021)

Article Cell Biology

Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis

Weizhou Jiang et al.

Summary: Mechanical loading is crucial for chondrocyte health, with mitochondria playing a critical role as mechanotransducers. Research has focused on the link between mechanical loading-induced mitochondrial dysfunction and the pathogenesis of osteoarthritis. There is a need for further investigation into the mechanisms behind mitochondrial functional alterations induced by mechanical stimulation.

AGEING RESEARCH REVIEWS (2021)

Review Pharmacology & Pharmacy

Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis

Zheng Tian et al.

Summary: OA is a common degenerative joint disease with no current clinical treatments available to stop or slow down its progression. Targeting autophagy-related pathways has been found to be crucial in maintaining cartilage homeostasis and treating OA. Phytochemicals derived from plant extracts show potential as complementary and alternative agents for OA treatment through modulating autophagy-related signaling pathways.

FRONTIERS IN PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis

Wenbin Pei et al.

Summary: In this study, it was found that Alantolactone (ALT) could alleviate IL-1 beta-induced inflammatory responses, protect cartilage from damage, and promote impaired autophagy through inhibiting the STAT3 and NF-kappa B signal pathways, suggesting a promising therapeutic effect for osteoarthritis.

FRONTIERS IN PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis

Stanislav Sukhikh et al.

Summary: Osteoarthritis is a degenerative joint disease without effective drugs to stop its progression. Phytonutraceuticals may have disease-modifying effects that can slow down the progression of OA and alleviate symptoms.

MOLECULES (2021)

Article Biotechnology & Applied Microbiology

Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF-κB Signaling Pathway

Meng Zhao et al.

Summary: The study demonstrated that bilobalide (BB) could effectively alleviate hepatic injury in streptozotocin-induced diabetic rats by improving glucose metabolism, blood lipid profiles, and liver function indicators. The mechanisms involve regulation of apoptosis-related proteins and fat metabolism related proteins, as well as modulation of AMPK and inflammatory pathways in hepatic tissues. AMPK inhibitor counteracted the protective effect of BB on liver injury. These findings suggest the potential therapeutic role of BB in alleviating liver damage in diabetic rats.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Pharmacology & Pharmacy

Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development

Haikang Zhou et al.

Summary: This study investigated the chondroprotective properties of NaB in inflammatory chondrocyte models and ACLT mouse models, revealing that NaB attenuated cartilage degradation by promoting autophagy to inhibit inflammation, oxidative stress, and apoptosis, thus reducing extracellular matrix degradation. The protective effects of NaB against OA were partially mediated by enhancing autophagy through the PI3K/Akt/mTOR pathway both in vitro and in vivo, suggesting NaB as a potential novel therapeutic approach for OA.

FRONTIERS IN PHARMACOLOGY (2021)

Review Medicine, General & Internal

Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology

Susanne Graessel et al.

Summary: Osteoarthritis is a common musculoskeletal condition that causes significant health and social problems worldwide, with its exact etiology still unclear. With an aging and increasingly obese population, the prevalence of the disease is increasing. Understanding the molecular mechanisms underlying the disease is crucial for future therapeutic approaches.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Pharmacology & Pharmacy

Rhoifolin Ameliorates Osteoarthritis via Regulating Autophagy

Jiyuan Yan et al.

Summary: Research has shown that ROF can alleviate symptoms of rat OA by regulating autophagy, indicating its potential therapeutic role.

FRONTIERS IN PHARMACOLOGY (2021)

Article Plant Sciences

Best practice in research - Overcoming common challenges in phytopharmacological research

Michael Heinrich et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

Review Plant Sciences

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

Gabriela Achete de Souza et al.

PLANTA MEDICA (2020)

Article Multidisciplinary Sciences

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

Justyna Sawa-Makarska et al.

SCIENCE (2020)

Review Cell Biology

The Role of Autophagy in Osteoarthritis

Ran Duan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Public, Environmental & Occupational Health

Effect of a multi-ingredient based food supplement on sexual function in women with low sexual desire

S. Palacios et al.

BMC WOMENS HEALTH (2019)

Article Biochemistry & Molecular Biology

A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress

Marianna Holczer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Bilobalide alleviates IL-17-induced inflammatory injury in ATDC5 cells by downregulation of microRNA-125a

Dongmei Mao et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)

Review Cell Biology

Interleukin-1β signaling in osteoarthritis - chondrocytes in focus

Zsuzsa Jenei-Lanzl et al.

CELLULAR SIGNALLING (2019)

Article Agriculture, Multidisciplinary

Ginkgo biloba sarcotesta polysaccharide inhibits inflammatory responses through suppressing both NF-κB and MAPK signaling pathway

Jing Ye et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2019)

Review Biochemistry & Molecular Biology

Autophagy and proinflammatory cytokines: Interactions and clinical implications

Yun Ge et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

Review Physiology

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

Claire Vinatier et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Rheumatology

Natural Products for Promoting Joint Health and Managing Osteoarthritis

Yves Henrotin et al.

CURRENT RHEUMATOLOGY REPORTS (2018)

Review Biochemistry & Molecular Biology

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

Tiantian Wang et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

Review Cell Biology

Modulation of inflammation by autophagy: Consequences for human disease

Romana T. Netea-Maier et al.

AUTOPHAGY (2016)

Editorial Material Cell Biology

How autophagy both activates and inhibits cellular senescence

Chanhee Kang et al.

AUTOPHAGY (2016)

Article Integrative & Complementary Medicine

Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β-induced catabolic gene expression in cartilage

Shiow-Yunn Sheu et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

Article Biochemistry & Molecular Biology

AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization

Daniel J. Asby et al.

CHEMISTRY & BIOLOGY (2015)

Review Genetics & Heredity

Pain assessment in animal models of osteoarthritis

Margaret J. Piel et al.

Article Behavioral Sciences

Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats

Michelle Goldie et al.

BEHAVIOURAL PHARMACOLOGY (2013)

Review Biochemistry & Molecular Biology

Autophagosome Formation and Molecular Mechanism of Autophagy

Isei Tanida

ANTIOXIDANTS & REDOX SIGNALING (2011)

Article Cell Biology

Mammalian autophagy: core molecular machinery and signaling regulation

Zhifen Yang et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

In Hye Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Food Science & Technology

Multifaceted therapeutic benefits of Ginkgo biloba L.: Chemistry, efficacy, safety, and uses

S. Mahadevan et al.

JOURNAL OF FOOD SCIENCE (2008)

Article Orthopedics

Osteoarthritis cartilage histopathology: grading and staging

KPH Pritzker et al.

OSTEOARTHRITIS AND CARTILAGE (2006)

Review Medicine, General & Internal

Drug therapy - Herbal remedies.

PAGM De Smet

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Medicine, General & Internal

A case of cerebral haemorrhage -: can Ginkgo biloba be implicated?

J Benjamin et al.

POSTGRADUATE MEDICAL JOURNAL (2001)