Current Evidence and Future Directions of Berberine Intervention in Depression

Review Biochemistry & Molecular Biology

The effects ofBerberis vulgarisL. andBerberis aristataL. in metabolic syndrome patients: a systematic and meta-analysis study

Babak Roshanravan et al.

Summary: Berberis vulgaris L. and Berberis aristata L. have beneficial effects in patients with metabolic syndrome, reducing LDL, total cholesterol, and triglyceride levels, and increasing HDL levels.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Review Biochemistry & Molecular Biology

An Updated Review on Therapeutic Potential and Recent Advances in Drug Delivery of Berberine: Current Status and Future Prospect

Md Ali Mujtaba et al.

Summary: This review provides an overview of the broad pharmacological activities of berberine (BBR), a phytochemical component with various biological and pharmacological effects. However, its oral bioavailability is limited, and efforts are needed to improve its properties for clinical applications.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2022)

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Article Neurosciences

Lithium therapy subdues neuroinflammation to maintain pyramidal cells arborization and rescues neurobehavioural impairments in ovariectomized rats

Anil Kumar Rana et al.

Summary: Estrogen deprivation during menopause leads to changes in brain neuronal circuit and neurobehavioral symptoms later in life. Hormone replacement therapy can partially alleviate these abnormalities but is associated with various adverse effects. This study investigated the effect of lithium therapy on neurobehavioral impairments in a rat model of ovariectomy, which mimics postmenopausal conditions. The results showed that lithium treatment protected against spatial and recognition memory impairments, as well as depression-like behavior in ovariectomized rats. Additionally, lithium treatment increased dendritic length and spine density in certain brain regions, reduced proinflammatory markers, normalized reactive astrogliosis, and modulated key signaling pathways. These findings suggest that lithium may be a potential therapeutic agent for managing postmenopausal neurological symptoms.

MOLECULAR NEUROBIOLOGY (2022)

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Article Cell Biology

Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression

Ning-Xi Zeng et al.

Summary: In this study, the mechanism by which Icariin (ICA) protects against hippocampal injury in depression was investigated through proteomics analysis of cerebrospinal fluid. The results showed that ICA can prevent depression and dysfunctional hippocampal neurogenesis through regulating the expression of certain proteins found in the cerebrospinal fluid.

NEURAL REGENERATION RESEARCH (2022)

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Review Neurosciences

Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders

Serena Camuso et al.

Summary: Brain-derived neurotrophic factor (BDNF) is a highly studied neurotrophin in the mammalian brain, crucial for the development of neurons and synaptic plasticity. It is expressed at higher levels in brain areas such as cerebellum and hippocampus. Dysregulation of BDNF expression is associated with neurodevelopmental disorders. Understanding the role of BDNF is important for researching and treating these disorders.

NEUROBIOLOGY OF DISEASE (2022)

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Article Clinical Neurology

Multifaceted interconnections between macrophage migration inhibitory factor and psychiatric disorders

Xi Chen et al.

Summary: This research paper discusses the role of inflammation in psychiatric disorders, with a focus on the potential role of MIF. The study provides new insights for the development of diagnostic and therapeutic biomarkers for psychiatric diseases based on MIF.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2022)

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Article Pharmacology & Pharmacy

Berberine ameliorates ovariectomy-induced anxiety-like behaviors by enrichment in equol generating gut microbiota

Yuan Fang et al.

Summary: The study demonstrates that berberine alleviates postmenopausal anxiety by modulating the gut microbiota under estrogen-deficient conditions. Experimental anxiety in ovariectomized rats was significantly reduced after berberine treatment, which increased beneficial gut microbes and equol generation. The findings suggest that berberine modulation of the gut microbiota is a promising therapeutic strategy for alleviating postmenopausal symptoms of anxiety.

PHARMACOLOGICAL RESEARCH (2021)

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Article Clinical Neurology

Validation of the Oxford Depression Questionnaire: Sensitivity to change, minimal clinically important difference, and response threshold for the assessment of emotional blunting

Michael Cronquist Christensen et al.

Summary: The study validates the clinical utility of the Oxford Depression Questionnaire (ODQ) in assessing emotional blunting in patients with MDD. After 8 weeks of vortioxetine treatment, there was a significant improvement in patients' ODQ scores, indicating a reduction in emotional blunting symptoms. The minimal clinically important difference in terms of change in ODQ-20 and ODQ-26 scores is suggested to be 16 and 20 points, respectively.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Medicine, Research & Experimental

Huang Lian Jie Du Tang attenuates paraquat-induced mitophagy in human SH-SY5Y cells: A traditional decoction with a novel therapeutic potential in treating Parkinson's disease

I-Jung Lee et al.

Summary: Huang Lian Jie Du Tang is used to treat Parkinson's disease and this study found that it can mitigate paraquat-induced cell death by regulating mitophagy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Editorial Material Clinical Neurology

Recent advances and challenges in major depressive disorder

Yong-Ku Kim

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

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Article Pharmacology & Pharmacy

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics

Shu-Yue Qu et al.

Summary: Depressive disorder is a prevalent mental disorder characterized by depressed mood and lack of interest or pleasure. Herbal medicine, such as Huang-lian Jie-du Decoction (HLJDD), has been explored as a complementary therapy for depression. This study demonstrates that HLJDD exhibits antidepressant effects by modulating tryptophan metabolism, serotonergic and dopaminergic synaptic activities, cAMP signaling pathway, and calcium signaling pathway, suggesting potential targets for its antidepressant action.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium

Tejveer Singh et al.

Summary: The study demonstrated the therapeutic potential of B. aquifolium root extract against HPV infection and cervical cancer by affecting the growth of CaCx cells and related molecular mechanisms through multiple pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Effect of Berberine Isolated from Barberry Species by Centrifugal Partition Chromatography on Memory and the Expression of Parvalbumin in the Mouse Hippocampus Proper

Radoslaw Szalak et al.

Summary: The study demonstrated that chronic administration of berberine at a higher dose improved long-term memory acquisition in mice and influenced the expression of parvalbumin in hippocampal neurons, suggesting a potential neuroprotective role against neuronal damages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nutrition & Dietetics

The Combination of Berberine, Tocotrienols and Coffee Extracts Improves Metabolic Profile and Liver Steatosis by the Modulation of Gut Microbiota and Hepatic miR-122 and miR-34a Expression in Mice

Valentina Cossiga et al.

Summary: The combination of plant extracts has beneficial effects on HFD-induced NAFLD by modulating miR-122, miR-34a, and gut microbiome.

NUTRIENTS (2021)

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Article Pharmacology & Pharmacy

Intranasal co-delivery of berberine and evodiamine by self-assembled thermosensitive in-situ hydrogels for improving depressive disorder

Dong Xu et al.

Summary: Orally administered antidepressants have side effects and slow effects, while a self-assembled hydrogel can increase the bioavailability of two components in Zuojin pill, improving depressive symptoms effectively.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Blood-Glucose-Lowering Effect of Coptidis Rhizoma Extracts From Different Origins via Gut Microbiota Modulation in db/db Mice

Yuanfeng Lyu et al.

Summary: Research has shown that different compositions of Coptidis rhizoma extracts (CREs) have varying effects on the degradation of berberine/jatrorrhizine/coptisine/palmatine in rat/mouse intestinal contents and on nine common gastrointestinal bacteria. When orally administered to db/db mice for two weeks, CREA showed the most significant impact on insulin/glucose tolerance test results and blood glucose levels.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Integrative & Complementary Medicine

Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats

Liao Cui-Ping et al.

Summary: The study showed that the metabolism pathways of Berberis amurensis extracts (BAEs) differed between normal rats and pseudo germ-free rats, indicating that intestinal bacteria have an influence on the metabolism of BAEs.

CHINESE JOURNAL OF NATURAL MEDICINES (2021)

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Article Clinical Neurology

Berberine Suppresses Mice Depression Behaviors and Promotes Hippocampal Neurons Growth Through Regulating the miR-34b-5p/miR-470-5p/BDNF Axis

Yuhua Zhan et al.

Summary: The study demonstrated that Berberine could inhibit depression behaviors and enhance hippocampal neuron growth by targeting miR-34b-5p and miR-470-5p in CUMS mice. Furthermore, it was found that BDNF was a target of miR-34b-5p and miR-470-5p, and the overexpression of BDNF could reverse the regulation of these miRNAs on depression behaviors and neuron growth. Additionally, Berberine could promote BDNF expression to regulate the progression of depression disorder.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

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Article Biochemistry & Molecular Biology

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota

Yan Wang et al.

Summary: Oral berberine may enhance dopamine production in the brain by promoting the generation of l-dopa through gut bacteria. Combining berberine with bacteria shows better therapeutic effects than using bacteria alone.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Neurosciences

Resveratrol reserved hypoxia-ischemia induced childhood hippocampal dysfunction and neurogenesis via improving mitochondrial dynamics

Hong Li et al.

NEUROSCIENCE RESEARCH (2020)

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Article Plant Sciences

Protective efficacy of Tinospora sinensis against streptozotocin induced pancreatic islet cell injuries of diabetic rats and its correlation to its phytochemical profiles

Anindita Banerjee et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Plant Sciences

Thalictrum foliolosum: A lesser unexplored medicinal herb from the Himalayan region as a source of valuable benzyl isoquinoline alkaloids

Nitin Sharma et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy

Regina G. Dare et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking

Xi Shen et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biotechnology & Applied Microbiology

In Vitro Anticancer Potential of Berberis lycium Royle Extracts against Human Hepatocarcinoma (HepG2) Cells

Kiren Mustafa et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Cell Biology

Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress

Yun-Ling Huang et al.

NEURAL REGENERATION RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell

Xiaohui Wang et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Review Cell Biology

Neurogenesis and antidepressant action

Seon-Cheol Park

CELL AND TISSUE RESEARCH (2019)

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Review Immunology

Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on TLR4 Signaling

Shofiul Azam et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Neurosciences

Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation

Jia-Wen Shou et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Food Science & Technology

Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines

Anna Och et al.

TOXINS (2019)

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Article Cell Biology

Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer's Disease

Yan Liu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Cell Biology

Pharmacological effects of berberine on mood disorders

Jie Fan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Obstetrics & Gynecology

Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study

Ruiyi Tang et al.

FERTILITY AND STERILITY (2019)

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Review Pharmacology & Pharmacy

Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery

Yan-Shuo Wang et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Neurosciences

Imaging the Role of Inflammation in Mood and Anxiety-related Disorders

Jennifer C. Felger

CURRENT NEUROPHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder

Bombi Lee et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2018)

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Review Medicine, General & Internal

Depression

Gin S. Malhi et al.

LANCET (2018)

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Article Integrative & Complementary Medicine

Altitudinal variation of berberine, total phenolics and flavonoid content in Thalictrum foliolosum and their correlation with antimicrobial and antioxidant activities

Garima Pandey et al.

JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE (2018)

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Article Clinical Neurology

Altered serum levels of TNF-α, IL-6, and IL-18 in depressive disorder patients

Ni Fan et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2017)

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Article Multidisciplinary Sciences

Berberine produces antidepressant-like effects in ovariectomized mice

Jie Fan et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

Berberine from Argemone mexicana L exhibits a broadspectrum antibacterial activity

Nilesh V. More et al.

ACTA BIOCHIMICA POLONICA (2017)

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Review Chemistry, Medicinal

Research progress on berberine with a special focus on its oral bioavailability

Chang-Shun Liu et al.

FITOTERAPIA (2016)

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Editorial Material Psychiatry

New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal

Guy Chouinard et al.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2015)

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Article Plant Sciences

Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

Peng-Ran Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2013)

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Review Clinical Neurology

Monoamine neurocircuitry in depression and strategies for new treatments

Michel Hamon et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2013)

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Article Pharmacology & Pharmacy

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Bombi Lee et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2012)

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Article Food Science & Technology

Antioxidant and antiproliferative properties of water extract from Mahonia bealei (Fort.) Carr. leaves

Weicheng Hu et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

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Article Chemistry, Medicinal

Seasonal variation of biomass and bioactive alkaloid content of goldenseal, Hydrastis canadensis

James A. Douglas et al.

FITOTERAPIA (2010)

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Review Chemistry, Medicinal

Intranasal Delivery to the Central Nervous System: Mechanisms and Experimental Considerations

Shyeilla V. Dhuria et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2010)

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Review Chemistry, Medicinal

Berberine: A Plant Alkaloid with Therapeutic Potential for Central Nervous System Disorders

S. K. Kulkarni et al.

PHYTOTHERAPY RESEARCH (2010)

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Article Plant Sciences

Antifungal alkaloids from the fresh rattan stem of Fibraurea recisa Pierre.

Gao-Xiong Rao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2009)

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Article Biotechnology & Applied Microbiology

Croatian barberry (Berberis croatica Horvat): a new source of berberine-analysis and antimicrobial activity

Ivan Kosalec et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2009)

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Article Chemistry, Medicinal

Antimicrobial activities of Indian Berberis species

Meenakshi Singh et al.

FITOTERAPIA (2007)

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Article Biochemistry & Molecular Biology

Effects of root isoquinoline alkaloids from Hydrastis canadensis on Fusarium oxysporum isolated from Hydrastis root tissue

Michael C. Tims et al.

JOURNAL OF CHEMICAL ECOLOGY (2007)

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Article Chemistry, Analytical

HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae

Jana Suchomelova et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2007)

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Current Evidence and Future Directions of Berberine Intervention in Depression

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