Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

Article Neurosciences

Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-α/NF-κB/caspase-3 signaling in type 2 diabetes rats

Xiao Chen et al.

Summary: The study found that hyperoside can prevent diabetes-induced cognitive dysfunction, neuroinflammation, and oxidative stress through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms in rats.

NUTRITIONAL NEUROSCIENCE (2022)

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Review Pharmacology & Pharmacy

The pharmacological activity of berberine, a review for liver protection

Mengting Zhou et al.

Summary: Liver plays a significant role in the body, but liver diseases are becoming a major public health issue globally. Traditional Chinese medicine has shown effective treatment for liver diseases with small side effects. Berberine has hepatoprotective effects and various pharmacological activities, and its metabolism and toxicity should be carefully considered for safe and effective clinical use.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Salidroside attenuates acute lung injury via inhibition of inflammatory cytokine production

Dan Song et al.

Summary: Salidroside attenuates acute lung injury by inhibiting inflammatory cytokine production, reducing LPS-induced pathological damage, and suppressing TNF-α and IL-6 secretion in the lung. This suggests that Salidroside may have a potential therapeutic effect in LPS-induced acute lung injury.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cell Biology

IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation

Jie Zhou et al.

Summary: High fructose can induce podocyte hypertrophy by down-regulating TTP, activating IL-6/STAT3 signaling, leading to abnormal podocyte proliferation and apoptosis. Inhibiting KHK-A to increase TTP may be a novel strategy for preventing high fructose-induced podocyte injury and proteinuria.

CELLULAR SIGNALLING (2021)

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Article Environmental Sciences

Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di-N-butyl-phthalate

Xiaolei Xu et al.

Summary: Ginsenoside Rg1 shows protective effects against DBP-induced reproductive function injury in mice, improving sperm density and motility, reducing testicular tissue damage, increasing serum hormone levels, regulating spermatogenesis-related proteins, restoring gap junctions, and activating the PI3K/Akt/mTOR signaling pathways.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Cell Biology

The roles of NLRP3 inflammasome-mediated signaling pathways in hyperuricemic nephropathy

Li Wen et al.

Summary: Hyperuricemic nephropathy is a common clinical complication caused by high serum uric acid levels, which triggers renal inflammation through the activation of the NLRP3 inflammasome. Research is currently focused on exploring potential therapeutic approaches targeting the NLRP3 inflammasome.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

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Article Cell Biology

Polydatin enhances glomerular podocyte autophagy homeostasis by improving Nrf2-dependent antioxidant capacity in fructose-fed rats

Ting-Ting Gu et al.

Summary: The study showed that polydatin alleviated fructose-induced autophagy imbalance through activating mTORC1, suppressing autophagy, and enhancing Nrf2-dependent antioxidant capacity.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

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Article Medicine, General & Internal

Efficacy, safety and response predictors of adjuvant astragalus for diabetic kidney disease (READY): study protocol of an add-on, assessor-blind, parallel, pragmatic randomised controlled trial

Kam Wa Chan et al.

Summary: This study aims to evaluate the effectiveness of add-on astragalus in patients with type 2 diabetes, stage 2-3 CKD and macroalbuminuria, and to identify related response predictors.

BMJ OPEN (2021)

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Review Biochemistry & Molecular Biology

Analytical determinations of luteolin

Alvaro Y. Tesio et al.

Summary: Plants produce primary and secondary metabolites through photosynthesis, with flavonoids being an important group of secondary metabolites known for their antioxidant properties. Luteolin, a flavone, is a bio-active compound with various health benefits and its study is an active field. Research on the quantification of luteolin is of special interest due to its transversal application across all fields.

BIOFACTORS (2021)

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Article Medicine, Research & Experimental

Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells - In vitro models simulating Alzheimer's disease pathology

Ling Rong Wong et al.

Summary: The study shows that berberine (BBR) can modulate mitochondrial bioenergetics and attenuate dysfunction of the primary energy and glutathione metabolism pathways in AD cell models, while also suppressing the production of pro-inflammatory cytokines in activated microglial cells. Both experimental and computational observations suggest that BBR and PIO have comparable binding affinities to the PPAR gamma protein, indicating potential overlapping effects for AD treatment.

LIFE SCIENCES (2021)

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Review Pharmacology & Pharmacy

Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review

Yuan Zhou et al.

Summary: Schisandra chinensis, a traditional herbal medicine, is commonly used in the treatment of liver and neurological diseases. Modern research has highlighted lignans as its main active ingredients, showing antioxidant, anti-inflammatory, and neuroprotective properties, as well as potential effects in cancer and fibrosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Plant Sciences

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Wen-jin Zhang et al.

Summary: Atractylodis Rhizoma, including Atractylodes lancea and Atractylodes chinensis, is widely used in East Asia for its diuretic and stomachic properties, as well as its treatment of rheumatic diseases, digestive disorders, night blindness, and influenza. Research has shown that it contains a variety of medicinal components and exhibits various pharmacological activities, particularly in improving gastrointestinal function.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Deciphering nutritional interventions for podocyte structure and function

Baris Afsar et al.

Summary: Despite increasing awareness and therapeutic options for chronic kidney disease (CKD), glomerular diseases still constitute a significant percentage of CKD. Proteinuria/albuminuria plays a direct pathogenic role in CKD progression and there is a need for more efficient and less toxic therapeutic options to treat glomerular diseases. In recent years, modifying dietary intake has gained attention as a potential treatment for podocyte function and structure.

PHARMACOLOGICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Emodin-A natural anthraquinone derivative with diverse pharmacological activities

Ruchi Badoni Semwal et al.

Summary: Emodin is a natural anthraquinone derivative that acts as a protein tyrosine kinase inhibitor and an anticancer drug, showing activity against various tumor cells. It is increasingly being studied for its potential in combination chemotherapy and its broad range of therapeutic activities.

PHYTOCHEMISTRY (2021)

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Article Plant Sciences

Atractylodis rhizoma water extract attenuates fructose-induced glomerular injury in rats through anti-oxidation to inhibit TRPC6/p-CaMK4 signaling

Li Chen et al.

Summary: The study investigated the potential of Atractylodis rhizoma water extract (ARE) in preventing glomerular injury through antioxidative effects, inhibiting TRPC6/p-CaMK4 signaling pathway, and up-regulating synaptopodin expression in a fructose-fed rat model.

PHYTOMEDICINE (2021)

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Article Medicine, Research & Experimental

Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPARγ-Klotho-FoxO1 axis in diabetic nephropathy

Lina Xing et al.

Summary: The study showed that AS-IV attenuated podocyte apoptosis by activating the PPAR gamma-Klotho-FoxO1 signaling pathway, leading to the inhibition of oxidative stress and amelioration of DN.

LIFE SCIENCES (2021)

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Review Pharmacology & Pharmacy

Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review

Fatemeh Yarmohammadi et al.

Summary: Curcumin has been shown to alleviate chemical and drug-induced cardiac injury by regulating Nrf2 and suppressing p38 MAPK/NF-kappa B and NLRP3 inflammasomes. It also has anti-apoptotic properties that modulate AMPK, Akt, JNK, and ERK signaling pathways in heart tissue. This review explores the potential protective effects of curcumin against detrimental effects in cardiac tissue caused by exposure to various chemicals and drugs.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy

Yan Li et al.

Summary: This study explored the therapeutic mechanisms of Cordyceps sinensis in diabetic nephropathy (DN) through network pharmacology analysis. Seven active ingredients were identified in Cordyceps, with potential therapeutic targets such as TNF, MAPK1, EGFR, ACE, and CASP3. Gene Ontology and KEGG pathway analyses showed that Cordyceps primarily affects inflammatory response, apoptosis, oxidative stress, and insulin resistance in treating DN.

JOURNAL OF DIABETES RESEARCH (2021)

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Review Pharmacology & Pharmacy

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Guoyi Tang et al.

Summary: Chinese medicine has shown promising clinical benefits in the treatment and management of diabetic nephropathy, with its multi-target function affecting crucial mechanisms such as glucose/lipid metabolism regulation, antioxidation, anti-inflammation, anti-fibrosis, and podocyte protection. Studies have emphasized the clinical efficacy of Chinese medicines and their bioactive components, with a focus on identifying the underlying mechanisms and molecular targets.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Medicine, General & Internal

Podocyte Autophagy in Homeostasis and Disease

Qisheng Lin et al.

Summary: Autophagy is a protective mechanism that helps cells maintain homeostasis and provide nutrition, with podocytes showing high levels of autophagy. Understanding the role and regulation of autophagy in podocyte injury may provide insights into novel therapeutic targets for glomerular disease.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications

Subrat Kumar Bhattamisra et al.

Summary: Catalpol isolated from Rehmannia glutinosa shows potent antioxidant properties and has been investigated for its effects on diabetes mellitus and its complications. The molecular pathways involved include promoting IRS-1/PI3K/AKT/GLUT2 activity, suppressing PEPCK and G6Pase expression in the liver, inducing myogenesis in skeletal muscles, and exerting antioxidant effects in the pancreas and liver. Catalpol also demonstrates neuroprotective, cardioprotective, and osteoblast stimulating effects, as well as potential in preventing neurodegeneration in the retina.

BIOMOLECULES (2021)

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Review Medicine, Research & Experimental

Resveratrol supplementation and acute pancreatitis: A comprehensive review

Shahram Agah et al.

Summary: Resveratrol, a natural polyphenolic ingredient extracted from herbs, has the potential to attenuate acute pancreatitis (AP) by directly impacting cytokine generation and exerting pharmacological effects through anti-inflammatory and antioxidant mechanisms. This review sheds light on the pathways through which resveratrol might impact the management and control of AP in the future.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Pharmacology & Pharmacy

Preparation and evaluation of lecithin/zein hybrid nanoparticles for the oral delivery of Panax notoginseng saponins

Wen Fu et al.

Summary: The study developed PLZ-NPs for enhanced oral absorption of Panax Notoginseng Saponins (PNS) with improved stability and enzymolysis resistance. PLZ-NPs showed higher permeability, absorption efficiency, and oral bioavailability compared to free PNS, making it a promising approach for PNS analogues.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Review Integrative & Complementary Medicine

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Teng- Huang et al.

Summary: Acupuncture, a traditional therapy with antioxidative, anti-inflammatory, and antiapoptotic effects, may alleviate oxidative stress in AD and PD animal models through activation of the Nrf2/ARE pathway, offering a potential therapeutic option for AD and PD.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Article Immunology

Hyperoside attenuates non-alcoholic fatty liver disease through targeting Nr4A1 in macrophages

Bing Sun et al.

Summary: The study demonstrates that hyperoside has a protective effect against high-fat diet-induced NAFLD and regulates macrophage polarization, alleviating hepatic steatosis, insulin resistance, and inflammatory responses. It shows that hyperoside may have therapeutic potential in preventing the pathological progression of NAFLD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Nanoscience & Nanotechnology

Functional Exosome-Mediated Delivery of Triptolide Endowed with Targeting Properties as Chemotherapy Carriers for Ovarian Carcinoma

Di He et al.

Summary: The exosome-encapsulated triptolide targeted drug delivery system significantly enhances anti-ovarian cancer effects and reduces toxicity, inducing apoptosis of ovarian cancer cells, regulating tumor immunity, and selectively inhibiting tumor-associated macrophages in the tumor microenvironment, showing promise as a treatment for ovarian cancer.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Recent Insights into the Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases

Feng Jiao et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

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Article Oncology

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR-mediated autophagy

Yunfeng Zhu et al.

Summary: The study demonstrated that AS-IV treatment could restore changes in food intake, water intake, urine volume, and body weight, and improve liver function and glucose homeostasis in T2DM rats. Furthermore, AS-IV treatment promoted suppressed autophagy in the liver of T2DM rats and improved IR, dyslipidaemia, oxidative stress, and inflammation, suggesting that AS-IV alleviated diabetic liver injury in T2DM rats through the promotion of AMPK/mTOR-mediated autophagy.

MOLECULAR MEDICINE REPORTS (2021)

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Article Endocrinology & Metabolism

Emodin Ameliorates Renal Damage and Podocyte Injury in a Rat Model of Diabetic Nephropathy via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway

Hong Liu et al.

Summary: Emodin effectively improves renal tissue damage and reduces proteinuria in diabetic nephropathy rats by regulating the AMPK/mTOR-autophagy signaling pathway, suppressing cell apoptosis and enhancing podocyte autophagy.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Article Plant Sciences

MYC2 Transcription Factors TwMYC2a and TwMYC2b Negatively Regulate Triptolide Biosynthesis in Tripterygium wilfordii Hairy Roots

Yanbo Huo et al.

Summary: This study identified MyC2 transcription factors TwMYC2a and TwMYC2b as negative regulators of triptolide biosynthesis in T. wilfordii, shedding light on the metabolic engineering potential for enhancing triptolide production.

PLANTS-BASEL (2021)

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Review Oncology

STAT3 pathway as a molecular target for resveratrol in breast cancer treatment

Zeynab Kohandel et al.

Summary: Activated STAT3 has been linked to breast cancer progression, proliferation, metastasis, and chemoresistance. Resveratrol, a natural phytoalexin, has shown anti-cancer activity and the ability to regulate the STAT3 signaling pathway, making it a potential tool for targeting STAT3 in breast cancer therapy.

CANCER CELL INTERNATIONAL (2021)

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Article Anatomy & Morphology

Renovation of Intestinal Barrier by Polydatin in Experimentally Induced Ulcerative Colitis: Comparative Ultrastructural Study with L-Carnosine

Hasnaa Ali Ebrahim et al.

Summary: The study demonstrated that PD pretreatment effectively restored normal mucosal epithelial cells in UC patients, suppressed inflammatory responses and apoptosis, and protected intestinal epithelial barrier function.

CELLS TISSUES ORGANS (2021)

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Article Pharmacology & Pharmacy

Silybin Restored CYP3A Expression through the Sirtuin 2/Nuclear Factor κ-B Pathway in Mouse Nonalcoholic Fatty Liver Disease

Ran Zhang et al.

Summary: Silybin restores CYP3A expression and activity in nonalcoholic fatty liver disease by regulating NAD(+) and SIRT2 levels, inhibiting liver inflammation, and lowering p65 acetylation, indicating the important role of the NAD(+)/SIRT2 pathway in CYP3A regulation.

DRUG METABOLISM AND DISPOSITION (2021)

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Review Nutrition & Dietetics

Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials

Gabriela Macedo Fraiz et al.

Summary: This review included seven randomized control trials and found that resveratrol supplementation could stimulate SIRT-1 in humans, leading to improvements in various metabolic markers related to excess weight and its comorbidities. However, more research is needed to confirm these effects.

EUROPEAN JOURNAL OF NUTRITION (2021)

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Article Integrative & Complementary Medicine

The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke

Chujun Zhang et al.

Summary: This study revealed that PNS suppresses the RIG-I signaling pathway, reducing inflammation and improving functional outcomes and cerebral vascular leakage in MCAO rats.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Article Agriculture, Multidisciplinary

De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae

Tian Liu et al.

Summary: In this study, polydatin was successfully produced from glucose through metabolic engineering and fermentation optimization, reaching a production of 545 mg/L, which was double that extracted from the roots of Polygonum cuspidatum. This suggests a potential shift from plant extraction to microbial chassis production mode for polydatin in the future.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Plant Sciences

Berberine for bone regeneration: Therapeutic potential and molecular mechanisms

Yuhan Zhang et al.

Summary: Berberine, a quaternary ammonium isoquinoline alkaloid extracted from various plants, has been traditionally used in medicine for its wide range of pharmacological effects. Recent studies have shown its potential in promoting bone regeneration, although further research is needed to fully understand its systemic mechanism in this process.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway

Yongkang Yang et al.

Summary: Hyperoside extracted from Hypericum perforatum and Crataegus pinnatifida has a protective effect on heart injury, improving cardiac function, reducing myocardial hypertrophy, and suppressing inflammation through regulating the autophagy pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4/MyD88/NF-κB signaling pathway

Hui Shi et al.

Summary: Astragaloside IV acts on MyD88 and improves myocardial injury, inflammation, and collagen deposition, alleviating acute myocardial infarction-induced cardiac damage. These findings suggest that Astragaloside IV may be an effective treatment for AMI.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Review Dentistry, Oral Surgery & Medicine

Curcumin: A review of experimental studies and mechanisms related to periodontitis treatment

Yongli Li et al.

Summary: Curcumin, the main active ingredient in turmeric, has potential therapeutic effects on periodontitis. Combining curcumin with other treatment methods may enhance its efficacy.

JOURNAL OF PERIODONTAL RESEARCH (2021)

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Review Clinical Neurology

Glucocorticoids for therapeutic immunosuppression: Clinical pearls for the practicing neurologist

Alexandra Galati et al.

Summary: Understanding the pharmacology and risks of glucocorticoids is crucial for neurologists due to their widespread use in neurological diseases. While dosing and tapering regimens may vary, there are general principles that can guide clinical decision-making. Glucocorticoid-related toxicities can affect multiple organ systems.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

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Article Oncology

Salidroside inhibits endothelial-mesenchymal transition via the KLF4/eNOS signaling pathway

Yongpan Huang et al.

Summary: This study revealed that SAL may inhibit Hcy-induced EndMT by regulating the KLF4/eNOS signaling pathway, thus improving the development of atherosclerosis.

MOLECULAR MEDICINE REPORTS (2021)

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Review Biochemistry & Molecular Biology

Cytotoxic and Proapoptotic Effects of Resveratrol in In Vitro Studies on Selected Types of Gastrointestinal Cancers

Katarzyna Ratajczak et al.

Summary: Cancer diseases pose a major challenge in clinical medicine globally, with drug resistance being a significant issue. Natural compounds, particularly polyphenols, are believed to have pleiotropic effects on cells and toxic effects on cancer cells, showing promise as a new approach to cancer treatment. Studies on the effectiveness of resveratrol in treating cancer, including reversing multidrug resistance, are ongoing and may provide valuable insights for future in vivo and clinical studies.

MOLECULES (2021)

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Review Plant Sciences

Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties

Xiao-Le Wang et al.

Summary: This review summarized the pre-clinical studies of paeoniflorin in treating depression and discussed its potential anti-depressive mechanisms, such as upregulation of neurotransmitters, neuroprotection, hippocampus neurogenesis, and inhibition of inflammatory reaction. While highlighting its effective properties in treating depression, more high-quality pre-clinical and clinical studies are needed for further exploration of its clinical application.

PHYTOMEDICINE (2021)

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Review Toxicology

Emodin: A metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets

Hardeep Singh Tuli et al.

Summary: The review summarizes the anti-neoplastic potential of emodin as a natural product metabolite in targeting tumor progression. Emodin has shown significant potential in inducing apoptosis, cell cycle arrest, inhibiting angiogenesis and metastasis, as well as overcoming chemoresistance in malignant cells.

TOXICOLOGY IN VITRO (2021)

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Article Medicine, Research & Experimental

A steroid-induced osteonecrosis model established using an organ-on-a-chip platform

Tengqi Li et al.

Summary: Bone microvascular endothelial cells (BMECs) play a central role in the development of steroid-induced osteonecrosis of the femoral head and can be cultured on a microfluidic organ-on-a-chip platform. The study showed that BMECs have better viability than HUVECs and that hydroxyapatite (HA) can promote BMECs growth. Glucocorticoids were found to cause damage to BMECs by inducing cleaved caspase 3/7, which was then protected by icariin on the microfluidic organ-on-a-chip platform.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Pharmacology & Pharmacy

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

Bu-Hui Liu et al.

Summary: The study showed that TFA protected podocytes from pyroptosis and injury induced by high glucose by regulating m(6)A modification, NLRP3 inflammasome activation, and PTEN/PI3K/Akt signaling.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Research Progress on Catalpol as Treatment for Atherosclerosis

Lei He et al.

Summary: Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common and serious conditions requiring attention. Traditional Chinese medicine and herbal drugs have been proven effective in treating coronary heart disease.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/ mTOR signaling pathway

Yi Ou et al.

Summary: Baicalin can decrease blood glucose levels in DN rats, improve renal morphology changes, and inhibit podocyte injury by affecting the expression of related proteins.

OPEN MEDICINE (2021)

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Article Plant Sciences

A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis

Hong Chang et al.

Summary: Baicalin can effectively treat pulmonary fibrosis by improving pathological changes, increasing SOD levels, reducing MDA and HYP levels, and regulating key biomarkers related to metabolism, leading to normalization or partial reversal of metabolite levels.

PHARMACEUTICAL BIOLOGY (2021)

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Review Urology & Nephrology

Diabetic Kidney Disease, Endothelial Damage, and Podocyte-Endothelial Crosstalk

Cindy Lora Gil et al.

Summary: Diabetes-related complications, such as diabetic kidney disease, are a major cause of morbidity and mortality worldwide. Chronic hyperglycemia can lead to endothelial cell dysfunction, disrupting the molecular crosstalk between endothelium and podocytes. Current therapies primarily focus on glycemia and blood pressure control, but overlook the importance of targeting endothelial dysfunction.

KIDNEY MEDICINE (2021)

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Article Oncology

Berberine alleviates palmitic acid-induced podocyte apoptosis by reducing reactive oxygen species-mediated endoplasmic reticulum stress

Xing-Yang Xiang et al.

Summary: The study found that BBR can reduce PA-induced podocyte apoptosis, while 4-phenylbutyric acid significantly decreased PA-induced cell apoptosis and expression of ER stress-related proteins, indicating that ER stress is involved in PA-induced podocyte apoptosis.

MOLECULAR MEDICINE REPORTS (2021)

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Article Plant Sciences

Cytotoxic monoterpenoid indole alkaloids from the aerial parts of Kopsia officinalis

Ting Liu et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2020)

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Article Endocrinology & Metabolism

Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the phosphatidylinositol 3-kinase-protein kinase B pathway in diabetic rats

Wei-Jian Ni et al.

JOURNAL OF DIABETES INVESTIGATION (2020)

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Article Biochemistry & Molecular Biology

Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects Probably via GABAA Receptor Regulation

Mikyung Kim et al.

BIOMOLECULES & THERAPEUTICS (2020)

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Article Medicine, Research & Experimental

Resveratrol alleviates obesity-associated podocyte injury in ovariectomized obese rats

Bing Li et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Protective effects of polydatin on multiple organ ischemia-reperfusion injury

Zhicheng Sun et al.

BIOORGANIC CHEMISTRY (2020)

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Article Integrative & Complementary Medicine

Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT/GSK3 β/β-Catenin Pathway by Restoring Autophagic Activity

Yimin Shi et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Medicine, Research & Experimental

Berberine mitigates high glucose-induced podocyte apoptosis by modulating autophagy via the mTOR/P70S6K/4EBP1 pathway

Chao Li et al.

LIFE SCIENCES (2020)

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Article Chemistry, Medicinal

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

Ling Xie et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Endocrinology & Metabolism

Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin I/UVRAG/Bcl2

Pingping Zhang et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

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Article Medicine, Research & Experimental

Baicalin serves a protective role in diabetic nephropathy through preventing high glucose-induced podocyte apoptosis

Jindong Li et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation

Xiang Tian et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Chemistry, Medicinal

Monoterpenoid indole alkaloids from the stems of Kopsia officinalis

Tian-Zhen Xie et al.

FITOTERAPIA (2020)

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Article Biochemistry & Molecular Biology

Curcumin attenuates angiotensin II-induced podocyte injury and apoptosis by inhibiting endoplasmic reticulum stress

Nan Yu et al.

FEBS OPEN BIO (2020)

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Article Integrative & Complementary Medicine

Ginsenoside Rg1 Alleviates Podocyte Injury Induced by Hyperlipidemia via Targeting the mTOR/NF-κB/NLRP3 Axis

Tao Wang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Medicine, Research & Experimental

Baicalin alleviates adriamycin-induced focal segmental glomerulosclerosis and proteinuria by inhibiting the Notch1-Snail axis mediated podocyte EMT

Yitian Dou et al.

LIFE SCIENCES (2020)

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Review Pharmacology & Pharmacy

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Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats

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Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy

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