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Exosomes Derived From Mesenchymal Stem Cells: Novel Effects in the Treatment of Ischemic Stroke

FRONTIERS IN NEUROSCIENCE (2022)

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Summary: CircOGDH may serve as a potential biomarker for penumbra in AIS patients and play a role in ischemic neuronal damage. CircOGDH interacts with miR-5112, enhancing COL4A4 expression and exacerbating neuron damage. Knockdown of CircOGDH enhances neuronal cell viability under ischemic conditions. Additionally, CircOGDH is enriched in neuron-derived exosomes in peripheral blood.

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Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation

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Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism

Ruben Garcia-Martin et al.

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Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward

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Summary: The protein kinase GSK-3 is a promising drug discovery target in treating multiple pathological conditions. Over the last decade, a range of GSK-3 inhibitors have been developed, with an increase in the indications tested. Clinical and pre-clinical studies have uncovered new mechanisms and insights into the contribution of GSK-3 to neurodegeneration and CNS-related disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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Potential Role of Exosomes in Ischemic Stroke Treatment

Lingling Jiang et al.

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Ping Xue et al.

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Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model

Yuanqiang Dai et al.

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INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Lucia Morales et al.

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MBIO (2022)

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Review Cardiac & Cardiovascular Systems

Modified Exosomes: a Good Transporter for miRNAs within Stem Cells to Treat Ischemic Heart Disease

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Summary: This study aims to explore the optimal therapeutic strategies of stem cells for spinal cord injury (SCI) through animal studies, provide guidance for clinical practice, and offer references for future research and clinical studies. The results show that various types of stem cells can significantly improve locomotor function in animals with SCI, with adipose-derived mesenchymal stem cells having the greatest therapeutic potential. A higher dose of stem cell transplantation, transplantation in the subacute phase, and intralesional transplantation are considered optimal strategies.

FRONTIERS IN PHARMACOLOGY (2022)

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Correction Biochemical Research Methods

Exosomes derived from microRNA-138-5poverexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2 (vol 13, 71, 2019)

Yiming Deng et al.

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Stem Cell-Derived Extracellular Vesicles as Potential Therapeutic Approach for Acute Kidney Injury

Marco Quaglia et al.

Summary: Acute kidney injury is a common and serious complication of hospitalized patients. Current treatment options are limited, but stem cell-derived extracellular vesicles show promise in treating acute kidney injury by directly interfering with pathogenic mechanisms and promoting cell protection, regeneration, and immunomodulation. Additionally, extracellular vesicles may have an impact on the transition from acute kidney injury to chronic kidney disease.

FRONTIERS IN IMMUNOLOGY (2022)

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LINC01426 contributes to clear cell renal cell carcinoma progression by modulating CTBP1/miR-423-5p/FOXM1 axis via interacting with IGF2BP1

YuFeng Jiang et al.

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MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke

Hongqi Xin et al.

Summary: Exosomes enriched with the MiR-17-92 cluster derived from multipotent mesenchymal stromal cells (MSCs) can enhance functional recovery after transient stroke, potentially by promoting axonal extension and myelination. This enhancement in axon-myelin remodeling may be mediated through the activation of the PI3K/Akt/mTOR pathway induced by downregulation of PTEN.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

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Activation of Neurogenesis in Multipotent Stem Cells CulturedIn Vitroand in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3

Francisco Javier Rodriguez-Jimenez et al.

Summary: Inhibition of GSK-3 can enhance neurogenesis and promote motor function recovery following SCI by activating beta-catenin signaling, increasing neuron differentiation, reducing astrocyte numbers, and improving motor function. Treatments with GSK-3 inhibitors also show potential for spinal cord tissue regeneration and increased expression of mature neurons, indicating a promising therapeutic strategy for SCI.

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Article Cell & Tissue Engineering

Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model

Vanessa Castelli et al.

Summary: Stem cells provide a basis for new therapeutic approaches, but further research is needed to understand their mechanisms, especially in vitro. Investigations on the secretome of human amniotic fluid stem cells have shown potential neuroprotective effects.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

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Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

Zhongfei Zhang et al.

Aging-US (2021)

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Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke

Jong-Won Chung et al.

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Review Biochemistry & Molecular Biology

The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application

Jafar Rezaie et al.

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Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Mikko T. Huuskonen et al.

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Ran Tian et al.

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Exosomes containing miR-451a is involved in the protective effect of cerebral ischemic preconditioning against cerebral ischemia and reperfusion injury

He Li et al.

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CNS NEUROSCIENCE & THERAPEUTICS (2021)

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Jia-Ying Li et al.

Summary: Exosomes play a crucial role in cerebral ischemia by regulating nervous system development, blood vessel remodeling, and neuroinflammation inhibition. They modulate stroke by improving neural communication, promoting neuronal cell development, neurovascular unit remodeling, and maintaining nervous system homeostasis. Exosomes also serve as effective carriers of bioactive substances, with potential for modification and targeted delivery to lesion sites for stroke treatment and prevention.

NEUROCHEMISTRY INTERNATIONAL (2021)

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miR-221 Exerts Neuroprotective Effects in Ischemic Stroke by Inhibiting the Proinflammatory Response

Yuan Shan et al.

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JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2021)

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Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis

Yamei Zhang et al.

Summary: The study indicates that ASC-EV-derived miR-22-3p attenuates brain ischemic injury by inhibiting the effects of KDM6B on the BMP2/BMF axis.

STEM CELL RESEARCH & THERAPY (2021)

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Challenges and Improvements of Novel Therapies for Ischemic Stroke

Lijun Yang et al.

Summary: Stroke is the third most common disease globally, particularly ischemic stroke causing severe neural cell death. While many therapies show promise in preclinical studies, few pass clinical trials. Novel methods such as traditional Chinese medicine, stem cell therapy, and exosomes are being explored for potential treatment of ischemic stroke.

FRONTIERS IN PHARMACOLOGY (2021)

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Schisandrin B Antagonizes Cardiotoxicity Induced by Pirarubicin by Inhibiting Mitochondrial Permeability Transition Pore (mPTP) Opening and Decreasing Cardiomyocyte Apoptosis

Hongwei Shi et al.

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FRONTIERS IN PHARMACOLOGY (2021)

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Zhe Kang Law et al.

Summary: The study aimed to investigate the safety and efficacy of intravenous autologous bone marrow-derived MSCs in patients with subacute middle cerebral artery infarct. Results showed improvement in absolute change in median infarct volume at 12 months in the treatment group, but no neurological recovery or functional outcome improvement.

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Therapeutic Effects of hiPSC-Derived Glial and Neuronal Progenitor Cells-Conditioned Medium in Experimental Ischemic Stroke in Rats

Diana Salikhova et al.

Summary: The study evaluated the therapeutic effects of conditioned media derived from human-induced pluripotent stem cell glial and neuronal progenitor cells in a rat middle cerebral artery occlusion model of ischemic stroke. The results showed pronounced cytoprotective, anti-inflammatory and angiogenic properties of soluble factors secreted by glial progenitor cells, but not by neuronal progenitor cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell & Tissue Engineering

Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine

Mason Daniel Hurd et al.

Summary: Ischemic stroke is a major cause of death and disability worldwide. While there are currently no clinically available treatments for damage sustained during an ischemic stroke, research on potential future treatments is ongoing. There are advantages and disadvantages in these potential treatments, but our understanding of them and their effectiveness in clinical trials are improving. Future treatments introduced in this review have the potential to become commonly used in clinical settings.

REGENERATIVE THERAPY (2021)

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Review Biochemistry & Molecular Biology

The Role of the ACE2/MasR Axis in Ischemic Stroke: New Insights for Therapy

Mansoureh Barzegar et al.

Summary: Ischemic stroke is the leading cause of neurologically based morbidity and mortality, and current treatments are limited to two classes of FDA-approved drugs with a narrow time-window for administration. There is a desperate need for new stroke therapies to suppress the deleterious effects of ischemic injury.

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Review Cell Biology

Biological Characteristics of Umbilical Cord Mesenchymal Stem Cells and Its Therapeutic Potential for Hematological Disorders

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New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

Maryam Mahjoubin-Tehran et al.

Summary: Non-coding RNAs, especially microRNAs and lncRNAs, play critical roles in angiogenesis and neuroprotection following ischemic stroke. Exosomes, serving as nanocarriers, are capable of transferring various ncRNAs and have significant inter-cellular roles in the mediation of neuro-restorative events after stroke. This review summarizes the pathogenic role of ncRNAs and exosomal ncRNAs in stroke.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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被撤回的出版物: Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3 (Retracted article. See vol. 189, pg. 153, 2022)

Zhibing Ai et al.

Summary: The study found that BMSC-EVs carrying miR-221-3p can inhibit ATF3, exerting a protective effect on MCAO mice and OGD-treated neurons, reducing inflammation, pathological changes, and cell apoptosis, which may help explore therapeutic strategies for IS.

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Ji Yoon Lee et al.

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MSCs-derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6

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Exosomes from Human Umbilical Vein Endothelial Cells Ameliorate Isch-emic Injuries by Suppressing the RNA Component of Mitochondrial RNA-processing Endoribonuclease via the Induction of miR-206/miR-1-3p Levels

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BMJ OPEN (2021)

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THERANOSTICS (2020)

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Article Biochemistry & Molecular Biology

Bone marrow-derived mesenchymal stem cells-derived exosomes prevent oligodendrocyte apoptosis through exosomal miR-134 by targeting caspase-8

Yilei Xiao et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion

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BIOMATERIALS (2019)

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Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu

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STEM CELL RESEARCH & THERAPY (2019)

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Article Peripheral Vascular Disease

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke

Kaiming Liu et al.

MICROVASCULAR RESEARCH (2019)

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Review Cell Biology

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

Sangiliyandi Gurunathan et al.

CELLS (2019)

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Plasma Exosomal miR-450b-5p as a Possible Biomarker and Therapeutic Target for Transient Ischaemic Attacks in Rats

XiuMei Luo et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2019)

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Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

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Article Neurosciences

Exosome-shuttled miR-92b-3p from ischemic preconditioned astrocytes protects neurons against oxygen and glucose deprivation

Lili Xu et al.

BRAIN RESEARCH (2019)

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Article Medicine, Research & Experimental

miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

Wei Zilun et al.

LIFE SCIENCES (2019)

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Article Cell Biology

Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF-1α-mediated promotion of angiogenesis in a rat model of stabilized fracture

Yuntong Zhang et al.

CELL PROLIFERATION (2019)

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Review Cell & Tissue Engineering

Potential of Exosomes for the Treatment of Stroke

Shi-Bin Hong et al.

CELL TRANSPLANTATION (2019)

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M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124

Yaying Song et al.

THERANOSTICS (2019)

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Clustered miRNAs and their role in biological functions and diseases

Shama P. Kabekkodu et al.

BIOLOGICAL REVIEWS (2018)

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Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

Mei Jiang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen-Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis

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JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

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Review Endocrinology & Metabolism

Role of microglia under cardiac and cerebral ischemia/reperfusion (I/R) injury

Poomarin Surinkaew et al.

METABOLIC BRAIN DISEASE (2018)

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Oleanolic acid protects against cognitive decline and neuroinflammation-mediated neurotoxicity by blocking secretory phospholipase A2 IIA-activated calcium signals

Leguo Zhang et al.

MOLECULAR IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis

Bei Shi et al.

PLOS ONE (2018)

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Article Medicine, Research & Experimental

Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function

Yin Hu et al.

THERANOSTICS (2018)

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Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Stella Cosenza et al.

THERANOSTICS (2018)

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MicroRNA-210 Promotes Accumulation of Neural Precursor Cells Around Ischemic Foci After Cerebral Ischemia by Regulating the SOCS1-STAT3-VEGF-C Pathway

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JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

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Exosomes Derived from miR-214-Enriched Bone Marrow-Derived Mesenchymal Stem Cells Regulate Oxidative Damage in Cardiac Stem Cells by Targeting CaMKII

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Geriatrics & Gerontology

Mitochondria in Ischemic Stroke: New Insight and Implications

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AGING AND DISEASE (2018)

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Review Clinical Neurology

Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function

Gaby Enzmann et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2018)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

Francisco J. Vizoso et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Neurosciences

Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

Connor Stonesifer et al.

PROGRESS IN NEUROBIOLOGY (2017)

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MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

Hongqi Xin et al.

STROKE (2017)

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Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells

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FRONTIERS IN PHARMACOLOGY (2017)

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

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MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

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COMPREHENSIVE PHYSIOLOGY (2017)

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Role of PTEN-Akt-CREB Signaling Pathway in Nervous System impairment of Rats with Chronic Arsenite Exposure

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BIOLOGICAL TRACE ELEMENT RESEARCH (2016)

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NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

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BRAIN BEHAVIOR AND IMMUNITY (2016)

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Human Neural Stem Cell Transplantation-Mediated Alteration of Microglial/Macrophage Phenotypes After Traumatic Brain Injury

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CELL TRANSPLANTATION (2016)

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Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction

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GENE (2016)

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Review Neurosciences

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

Xiao-Yi Xiong et al.

PROGRESS IN NEUROBIOLOGY (2016)

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Article Cell & Tissue Engineering

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

Johnathon D. Anderson et al.

STEM CELLS (2016)

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Article Clinical Neurology

Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke A Prospective Observational Study

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STROKE (2016)

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Article Oncology

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke

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ONCOTARGET (2016)

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Article Cell & Tissue Engineering

Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews

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STEM CELLS INTERNATIONAL (2016)

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Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

Mohsin Khan et al.

CIRCULATION RESEARCH (2015)

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Editorial Material Cell Biology

Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives

Anuradha Kalani et al.

Neural Regeneration Research (2015)

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Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy

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STEM CELL RESEARCH & THERAPY (2015)

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Review Immunology

Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications

Marta E. Castro-Manrreza et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

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Neuroprotective Effects of Viral Overexpression of microRNA-22 in Rat and Cell Models of Cerebral Ischemia-Reperfusion Injury

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JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

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Melatonin treatment further improves adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in rat

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JOURNAL OF PINEAL RESEARCH (2014)

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Review Neurosciences

Exosomes/miRNAs as mediating cell-based therapy of stroke

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FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

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Innate immune activation in neurodegenerative disease

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NATURE REVIEWS IMMUNOLOGY (2014)

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MicroRNA-124 Protects Neurons Against Apoptosis in Cerebral Ischemic Stroke

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CNS NEUROSCIENCE & THERAPEUTICS (2013)

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Stem cells as promising therapeutic options for neurological disorders

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JOURNAL OF CELLULAR BIOCHEMISTRY (2013)

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Article Cell & Tissue Engineering

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

Hongqi Xin et al.

STEM CELLS (2013)

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Article Cell Biology

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

Yuan-Lei Lou et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)

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Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

Xiaoming Hu et al.

STROKE (2012)

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Article Neurosciences

Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct

Hideo Shichinohe et al.

BRAIN RESEARCH (2007)

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MicroRNAs in disease and potential therapeutic applications

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MOLECULAR THERAPY (2007)

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