NLRP3 Inflammasome Activation: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury

Article Neurosciences

NLRP3 inflammasome activation increases brain oxidative stress after transient global cerebral ischemia in rats

Larissa Silva Joaquim et al.

Summary: The study demonstrates that inhibiting NLRP3 activation with MCC950 can reduce brain oxidative damage after cerebral ischemia/reperfusion in rats.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2023)

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Article Biochemistry & Molecular Biology

Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation

Arjun Sapkota et al.

Summary: Oleanolic acid shows therapeutic potential in protecting against acute and chronic brain injuries after ischemic stroke by reducing brain infarction, improving neurological deficits, and attenuating brain tissue loss.

BIOMOLECULES & THERAPEUTICS (2022)

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Article Cell Biology

Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway

Ning Wang et al.

Summary: Dex promotes M2 polarization of microglia, attenuates oxidative stress and inflammation, and protects against cerebral ischemic injury by activating the Nrf2/HO-1 pathway and inhibiting NLRP3 inflammasome.

INFLAMMATION RESEARCH (2022)

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Article Immunology

USP20 mitigates ischemic stroke in mice by suppressing neuroinflammation and neuron death via regulating PTEN signal

Rujun Pan et al.

Summary: Ischemic stroke is a major cause of death worldwide, and the lack of effective pharmacotherapies is due to incomplete understanding of its pathogenesis. USP20 plays a crucial role in cerebral ischemic stroke, and over-expression of USP20 can alleviate brain injury, reduce infarct volume, improve cognitive function, inhibit microglial activation and inflammatory response, and reduce neuronal death. In addition, USP20 directly interacts with PTEN and can ameliorate neuroinflammation and neuron death induced by ischemic stroke through regulating PTEN.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Neurosciences

Agomelatine Exerts an Anti-inflammatory Effect by Inhibiting Microglial Activation Through TLR4/NLRP3 Pathway in pMCAO Rats

Wijitra Chumboatong et al.

Summary: Agomelatine treatment in a rat model of permanent middle cerebral artery occlusion (pMCAO) demonstrated anti-inflammatory effects by inhibiting microglial activation through the TLR4/NLRP3 signaling pathway, leading to reduced brain damage.

NEUROTOXICITY RESEARCH (2022)

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Article Cell Biology

NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke

Maximilian Bellut et al.

Summary: This study reveals that NLRP3 inflammasome plays a critical role in ischemic stroke, disrupting the blood-brain barrier through activating inflammatory signaling cascades and inflammatory cell death.

CELL DEATH & DISEASE (2022)

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Article Chemistry, Medicinal

Protective Effects of Remimazolam on Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis

Min Shi et al.

Summary: This study found that Remimazolam has a protective effect against cerebral ischemia/reperfusion (I/R) injury by suppressing pyroptosis and reducing the expression and release of inflammatory factors, with the involvement of the NLRP3 inflammasome pathway. This suggests that Remimazolam may be a promising anesthetic drug for patients with ischemic stroke.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

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Article Multidisciplinary Sciences

Changes in the incidence and prevalence of ischemic stroke and associations with natural disasters: an ecological study in 193 countries

Kai-Sen Huang et al.

Summary: Natural disasters have significant impacts on the incidence and prevalence of ischemic stroke globally, with different regions showing varying trends over the past 28 years. The occurrence of disasters is independently and positively associated with the incidence and prevalence of ischemic stroke in males, females, and both genders combined. This evidence supports the need for policy making and resource allocation for disaster response and reducing the disease burden.

SCIENTIFIC REPORTS (2022)

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Review Chemistry, Medicinal

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Qing-zhang Tuo et al.

Summary: Ischemic stroke caused by arterial occlusion is a common type of stroke that involves multiple cell death pathways such as apoptosis, necroptosis, and autophagy. Understanding these pathways may reveal new neuroprotective interventions for ischemic stroke.

MEDICINAL RESEARCH REVIEWS (2022)

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Article Neurosciences

GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke

Y. Zhang et al.

Summary: This study investigated whether lysosomal dysfunction in neurons can be restored by inhibiting GSK-3β to alleviate post-stroke damage. The results showed that GSK-3β inhibition can significantly mitigate neurological injury in ischemic stroke, and the alteration of lysosomal capacity affects this neuroprotection.

BRAIN RESEARCH (2022)

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Article Immunology

Poncirin ameliorates oxygen glucose deprivation/reperfusion injury in cortical neurons via inhibiting NOX4-mediated NLRP3 inflammasome activation

Ruili Wang et al.

Summary: Poncirin protects cortical neurons from oxygen-glucose deprivation/reoxygenation injury by inhibiting the NOX4/ROS/NLRP3 axis. It alleviates neuronal damage caused by mitochondrial dysfunction, oxidative stress, and inflammatory response.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

SET domain containing 7 promotes oxygen-glucose deprivation/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1/Nrf2/ARE and NF-κB pathways

Xianfang Pan et al.

Summary: This study demonstrates that silence of SETD7 can improve the inflammation and oxidative stress in a cell model of cerebral ischemia-reperfusion injury, through inactivation of NF-kappa B and activation of Keap1/Nrf2/ ARE pathway.

BIOENGINEERED (2022)

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Article Integrative & Complementary Medicine

Protective Effect of Naoxintong Capsule Combined with Guhong Injection on Rat Brain Microvascular Endothelial Cells during Cerebral Ischemia-Reperfusion Injury

Hai-yan Wang et al.

Summary: The combination application of NXTC and GHI in cerebral I/R injury model showed protective effects, reducing cell apoptosis, increasing SOD levels, decreasing MDA levels, and enhancing mitochondrial membrane potential.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

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Article Immunology

The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice

Maximilian Franke et al.

Summary: The study demonstrates that induction of NLRP3 inflammasome in neurons plays a crucial role in neuroinflammation during acute ischemic stroke. Early blockade of NLRP3 can protect against I/R injury by reducing inflammation and stabilizing the blood-brain barrier.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Multidisciplinary Sciences

Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation

Jargalsaikhan Dagvadorj et al.

Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Immunology

6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1/FAF1 complex dissociation-mediated autophagy

Jing Luo et al.

Summary: 6-Gingerol treatment reduces NLRP3 inflammasome-derived inflammation and neuronal apoptosis, while promoting autophagy, contributing to its therapeutic effects on cerebral I/R injury.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Neurosciences

PAF Receptor Inhibition Attenuates Neuronal Pyroptosis in Cerebral Ischemia/Reperfusion Injury

Bo Zhao et al.

Summary: The study demonstrates that PAFR plays a role in neuronal pyroptosis after I/R injury, and the specific PAFR inhibitor XQ-1H has potential in attenuating I/R injury by reducing pyroptosis.

MOLECULAR NEUROBIOLOGY (2021)

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Review Toxicology

The role of lysosomal ion channels in lysosome dysfunction

Rebekah L. Kendall et al.

Summary: Lysosomal ion channels play a crucial role in maintaining cellular homeostasis by influencing degradation, autophagy, membrane potential, Ca2+ signaling, and exocytosis. Dysfunctions in these ion channels can lead to various disease pathologies, highlighting the importance of understanding their role in lysosome dysfunction. This knowledge could also provide insights into the effectiveness of drugs targeting lysosomes, such as cationic amphiphilic drugs.

INHALATION TOXICOLOGY (2021)

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Article Cell Biology

Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy

Zhenzhen Hu et al.

Summary: The study demonstrated that MSC-exos enhance mitophagy by increasing FOXO3a expression, thereby protecting microglia from I/R-induced pyroptosis and alleviating subsequent neuronal injury.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Neurosciences

Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-kappa B/NLRP3 Pathway in Ischemic Stroke

Fengyang Li et al.

Summary: The study demonstrates that the combination of indobufen or aspirin with clopidogrel or ticagrelor as pretreatment shows protective effects against cerebral ischemic injury by inhibiting the NF-kappa B/NLRP3 pathway, reducing inflammatory response, and decreasing infarct size, brain edema, LDH release, and neurological impairment. The combination also reduces inflammasome mediated pyroptosis in both in vivo and in vitro models, suggesting a potential clinical strategy for treating ischemia/reperfusion-induced injury.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells

Rong Ji et al.

Summary: The expression of IDO-1 in perivascular and meninges macrophages/microglia increases cellular phagocytic capacity and might suppress overactivation of inflammatory reaction, according to the study's findings.

PLOS ONE (2021)

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Article Physiology

Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling

Yuewei Xu et al.

Summary: This study showed that pretreatment with BAK could improve neurological deficits, reduce infarct volume, cerebral edema, and neuronal injury in MCAO/R-injured mice. The protective effect of BAK may be attributed to its ability to suppress NLRP3-mediated inflammatory response and activate the Nrf2 signaling pathway.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2021)

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Article Clinical Neurology

Edaravone Dexborneol Versus Edaravone Alone for the Treatment of Acute Ischemic Stroke A Phase III, Randomized, Double-Blind, Comparative Trial

Jie Xu et al.

Summary: In this clinical trial, edaravone dexborneol was found to have better functional outcomes at 90 days in patients with acute ischemic stroke, especially in female patients.

STROKE (2021)

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Article Toxicology

Lysophosphatidylcholine induces apoptosis and inflammatory damage in brain microvascular endothelial cells via GPR4-mediated NLRP3 inflammasome activation

Tao Liu et al.

TOXICOLOGY IN VITRO (2021)

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Article Geriatrics & Gerontology

Enriched Environment Attenuates Pyroptosis to Improve Functional Recovery After Cerebral Ischemia/Reperfusion Injury

Jingying Liu et al.

Summary: The study found that enriched environment (EE) treatment improved functional recovery after cerebral ischemia/reperfusion (I/R) injury, reduced infarct volume, and attenuated neuronal pyroptosis. These effects may be achieved through inhibiting the NF-kappa B p65 signaling pathway and the activities of NLRP1/NLRP3 inflammasomes.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies

Xue Gou et al.

Summary: Stroke is a common disease with high mortality and disability worldwide. Pyroptosis plays a crucial role in ischemic or hemorrhagic brain tissue, and the relationship between inflammation and stroke is increasingly recognized.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis

Heng-Sheng Zhang et al.

Summary: The study revealed that Gastrodin (GAS) significantly improved neurological scores and reduced cerebral infarction area in rats by modulating the lncRNA NEAT1/miR-22-3p axis. GAS inhibited pyroptosis by downregulating NLRP3, inflammatory factors (IL-1 beta, IL-18), and cleaved caspase-1. Furthermore, GAS attenuated I/R-induced inflammation in neuronal cells through the modulation of the lncRNA NEAT1/miR-22-3p axis.

NEUROCHEMICAL RESEARCH (2021)

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Review Cell Biology

Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms

Jia-Xin Ren et al.

Summary: Oxidative stress and ferroptosis/oxytosis are key factors in ischemic stroke, sharing common molecular pathways. Understanding the interaction between oxidative stress and ferroptosis/oxytosis is crucial for a better comprehension and treatment of ischemic stroke.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Clinical Neurology

Temporal and Spatial Dynamics of Inflammasome Activation After Ischemic Stroke

Danli Lu et al.

Summary: Inflammasome activation following stroke can have detrimental effects, particularly on macrophages. Targeting the executing enzymes of inflammasomes may provide potential and efficient therapeutic effects, reducing infarct size and neurological deficits in stroke models.

FRONTIERS IN NEUROLOGY (2021)

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Article Clinical Neurology

Association between serum NLRP3 and malignant brain edema in patients with acute ischemic stroke

Yanan Wang et al.

Summary: This study aimed to explore the association between serum NLRP3 levels and MBE development in patients with acute ischemic stroke. The findings showed a trend of increased MBE risk with higher NLRP3 concentrations, potentially influenced by stroke severity, warranting further validation in large cohort studies.

BMC NEUROLOGY (2021)

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Article Integrative & Complementary Medicine

Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid-β Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats

Bing Wang et al.

Summary: The research indicates that TXL can protect ischemic brain tissues by inhibiting astrocytic pyroptosis and reducing Aβ accumulation after cerebral ischemia/reperfusion injury, potentially offering a preventive and therapeutic approach for poststroke dementia in clinical practice.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Article Oncology

Exosomes derived from hypoxic bone marrow mesenchymal stem cells rescue OGD-induced injury in neural cells by suppressing NLRP3 inflammasome-mediated pyroptosis

Xiuwen Kang et al.

Summary: Exosomes derived from bone marrow mesenchymal stromal cells have been shown to have significant neuroprotective effects against NLRP3 inflammasome-mediated pyroptosis in cerebral ischemic diseases. Hypoxic exosomes demonstrate more pronounced protective effects compared to normoxic exosomes, indicating their potential for clinical use in treating cerebral ischemia and hypoxia injuries.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Neurosciences

Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes

Xiaoli Liu et al.

Summary: The study demonstrated that BMSC-Exos attenuated cerebral I/R injury by suppressing NLRP3 inflammasome-mediated inflammation and pyroptosis, and also by modulating microglial polarization, ultimately providing neuroprotective effects.

EXPERIMENTAL NEUROLOGY (2021)

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Article Cell Biology

Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke

Lei Li et al.

Summary: Oridonin, a natural compound extracted from a Chinese herb, has been shown to protect against oxidative stress-induced endothelial injury by promoting nuclear translocation of Nrf-2. It repairs the blood-brain barrier and reduces infarct volume in ischemic stroke mice by activating signaling pathways. These findings suggest the potential therapeutic effect of oridonin in ischemic stroke treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Immunology

Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke

Ceshu Gao et al.

Summary: The downregulation of CD151 reduced neurological injuries, improved outcomes, and decreased infiltration of neutrophils and monocytes. It also restricted the activation of the p38 MAPK and NF-kappa B pathways, leading to decreased expression of VCAM-1. However, the downregulation of CD151 did not directly impact the activation of neutrophils and monocytes.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Pharmacology & Pharmacy

Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis

Yunjie Wang et al.

Summary: The study revealed that pyroptosis of BMVECs may be involved in the pathogenesis of ischemic stroke, and the novel PGC-1 alpha activator MDN could ameliorate pyroptosis and ischemic brain injury by reducing mtROS through the PPAR alpha/GOT1 axis in BMVECs. Targeting endothelial pyroptosis by MDN may provide alternative therapeutics for brain ischemic stroke.

PHARMACOLOGICAL RESEARCH (2021)

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Article Anatomy & Morphology

Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation

Yujie Jia et al.

Summary: This study revealed that oridonin can alleviate cerebral ischemia/reperfusion injury by relieving neurological deficits, neuronal injury, and microglia activation, as well as inhibiting the activation of the NLRP3 inflammasome through the NF-kappa B signaling pathway. Thus, oridonin shows potential as a candidate for therapy of cerebral ischemia/reperfusion injury in the future.

TISSUE & CELL (2021)

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Review Clinical Neurology

Effects of Microglial Activation and Polarization on Brain Injury After Stroke

Rui Dong et al.

Summary: Investigating the activation and polarizing mechanisms of microglia is critical in stroke treatment as it can impact the prognosis of stroke.

FRONTIERS IN NEUROLOGY (2021)

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Review Immunology

Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

Nan Ji et al.

Summary: Pyroptosis is a form of pro-inflammatory cell death mediated by the Gasdermin family and releases inflammatory cytokines. It is closely related to cardiovascular diseases such as myocardial infarction, ischemia-reperfusion, and atherosclerosis.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Plant Sciences

Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia

Zhen-Tao Mo et al.

Summary: The study demonstrated that Icariin may reduce the expression of IL-1 beta, IL-6 and TNF-alpha by inhibiting the IRE1/XBP1s pathway, suggesting a potential therapeutic strategy for brain injury after stroke.

PHARMACEUTICAL BIOLOGY (2021)

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Article Neurosciences

LncRNA TUG1 Demethylated by TET2 Promotes NLRP3 Expression, Contributes to Cerebral Ischemia/Reperfusion Inflammatory Injury

Min Yin et al.

Summary: This study found that TUG1 lncRNA is upregulated in cerebral ischemia/reperfusion (I/R) injury, and TET2-mediated demethylation can alleviate inflammatory responses. Interaction between TUG1 and miR-200a-3p regulates NLRP3-dependent inflammation, while TET2 influences injury severity by modulating the TUG1/miR-200a-3p/NLRP3 pathway.

ASN NEURO (2021)

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Article Integrative & Complementary Medicine

Protective Effect of Naoxintong Capsule Combined with Guhong Injection on Rat Brain Microvascular Endothelial Cells during Cerebral Ischemia-Reperfusion Injury

Hai-yan Wang et al.

Summary: The combined application of Naoxintong Capsule and Guhong Injection on cerebral ischemia-reperfusion injury showed protective benefits, reducing apoptotic rate, increasing SOD levels, and decreasing MDA levels.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021)

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Article Pharmacology & Pharmacy

Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice

Qinyu Wang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Review Cell Biology

Target of MCC950 in Inhibition of NLRP3 Inflammasome Activation: a Literature Review

Danbin Wu et al.

INFLAMMATION (2020)

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Article Neurosciences

Adiponectin reduces brain injury after intracerebral hemorrhage by reducing NLRP3 inflammasome expression

Shaohua Wang et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2020)

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Article Plant Sciences

Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption

Danli Cui et al.

PHYTOMEDICINE (2020)

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Article Medicine, Research & Experimental

Effects of irisin on osteoblast apoptosis and osteoporosis in postmenopausal osteoporosis rats through upregulating Nrf2 and inhibiting NLRP3 inflammasome

Lili Xu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Article Multidisciplinary Sciences

Tetrandrine alleviates cerebral ischemia/reperfusion injury by suppressing NLRP3 inflammasome activation via Sirt-1

Jun Wang et al.

PEERJ (2020)

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Article Pharmacology & Pharmacy

Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling

Jie Zhao et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Neurosciences

Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway

Meng-Yuan Diao et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Immunology

Astilbin protects against cerebral ischaemia/reperfusion injury by inhibiting cellular apoptosis and ROS-NLRP3 inflammasome axis activation

Yu Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

Min Zheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Review Medicine, Research & Experimental

Non-coding RNAs participate in the ischemia-reperfusion injury

Soudeh Ghafouri-Fard et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity

Jialing Peng et al.

MOLECULAR IMMUNOLOGY (2020)

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Article Neurosciences

Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

Qing Zeng et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Neurosciences

MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation

Qiao-Sheng Wang et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

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Article Biochemistry & Molecular Biology

Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation

Gabriela Warpsinski et al.

REDOX BIOLOGY (2020)

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Article Medicine, Research & Experimental

D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway

Mengyuan Dai et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Clinical Neurology

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

Kankai Wang et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Biochemistry & Molecular Biology

Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury

Jung Hwan Park et al.

BMB REPORTS (2020)

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Article Immunology

Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury

Rui Sun et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Neurosciences

miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke

Junna He et al.

FOLIA NEUROPATHOLOGICA (2020)

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Article Neurosciences

Melodinhenine B attenuates NLRP3 expression in a cerebral ischemia/reperfusion-induced neuronal injury rat model

Wei Li et al.

FOLIA NEUROPATHOLOGICA (2020)

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Article Cell & Tissue Engineering

Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop

Fan Chen et al.

BONE RESEARCH (2020)

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Article Immunology

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress

Wen-yuan Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

Zhilei Wang et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Review Medicine, Research & Experimental

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie Voet et al.

EMBO MOLECULAR MEDICINE (2019)

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Review Clinical Neurology

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

Masoumeh Alishahi et al.

INTERNATIONAL JOURNAL OF STROKE (2019)

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Article Neurosciences

FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation

Shu Yao et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats

Tao Jiang et al.

MOLECULAR MEDICINE (2019)

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Article Biochemistry & Molecular Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

Ana Tapia-Abelian et al.

NATURE CHEMICAL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption

Marco A. Gianfrancesco et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2019)

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Article Immunology

Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson's disease via promoting mitophagy

Zhao-Li Hu et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Medicine, Research & Experimental

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

Mei Xue et al.

CLINICAL SCIENCE (2019)

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Article Oncology

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Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation

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Intermittent fasting attenuates inflammasome activity in ischemic stroke

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NLRP3 Inflammasome Activation Results in Hepatocyte Pyroptosis, Liver Inflammation, and Fibrosis in Mice

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Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux

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RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

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Hypoxia Induces Autophagic Cell Death through Hypoxia-Inducible Factor 1α in Microglia

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NLRP3 Inflammasomes Show High Expression in Aorta of Patients with Atherosclerosis

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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

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The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

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Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

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Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats

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Critical functions of priming and lysosomal damage for NLRP3 activation

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NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

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FEBS JOURNAL (2009)

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Alternative activation of macrophages: Immune function and cellular biology

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Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the NlrP3 Inflammasome

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Cryopyrin activates the inflammasome in response to toxins and ATP

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SL Fink et al.

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NLRP3 Inflammasome Activation: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury

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