4.5 Article

Excitatory and Inhibitory Synaptic Imbalance Caused by Brain-Derived Neurotrophic Factor Deficits During Development in a Valproic Acid Mouse Model of Autism

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出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.860275

关键词

synaptic development; E; I balance; autism; BDNF; excitatory synapse; inhibitory synapse; valproic acid

资金

  1. National Natural Science Foundation of China [81730035, 82071536, 81771476]
  2. Shaanxi Provincial Key Research and Development Program [2020ZDLSF01-09]
  3. Shaanxi Key Research and Development Program [2020SF-127]
  4. CAS Key Laboratory of Brain Connectome and Manipulation [2019DP173024]

向作者/读者索取更多资源

This study explored the role of environmental factors, specifically medication during pregnancy, in the development of autism spectrum disorder (ASD). The researchers found that exposure to valproic acid (VPA) during pregnancy led to changes in excitatory and inhibitory synaptic function and contributed to ASD-like behaviors. They also discovered that treatment with exogenous brain-derived neurotrophic factor (BDNF) rescued synaptic functions and improved social defects in the mouse model.
Environmental factors, such as medication during pregnancy, are one of the major causes of autism spectrum disorder (ASD). Valproic acid (VPA) intake during pregnancy has been reported to dramatically elevate autism risk in offspring. Recently, researchers have proposed that VPA exposure could induce excitatory or inhibitory synaptic dysfunction. However, it remains to be determined whether and how alterations in the excitatory/inhibitory (E/I) balance contribute to VPA-induced ASD in a mouse model. In the present study, we explored changes in the E/I balance during different developmental periods in a VPA mouse model. We found that typical markers of pre- and postsynaptic excitatory and inhibitory function involved in E/I balance markedly decreased during development, reflecting difficulties in the development of synaptic plasticity in VPA-exposed mice. The expression of brain-derived neurotrophic factor (BDNF), a neurotrophin that promotes the formation and maturation of glutamatergic and GABAergic synapses during postnatal development, was severely reduced in the VPA-exposed group. Treatment with exogenous BDNF during the critical E/I imbalance period rescued synaptic functions and autism-like behaviors, such as social defects. With these results, we experimentally showed that social dysfunction in the VPA mouse model of autism might be caused by E/I imbalance stemming from BDNF deficits during the developmental stage.

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