期刊
JOURNAL OF BIOMECHANICS
卷 49, 期 14, 页码 3543-3548出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2016.08.025
关键词
Pulmonary acinus; Anisotropic expansion; Numerical simulations; CFD; Particle transport; Aerosol deposition
资金
- Israel Science Foundation [990/12]
- European Research Council (ERC) under the European Union [677772]
- European Research Council (ERC) [677772] Funding Source: European Research Council (ERC)
Lung deformations at the local pulmonary acinar scale are intrinsically anisotropic. Despite progress in imaging modalities, the true heterogeneous nature of acinar expansion during breathing remains controversial, where our understanding of inhaled aerosol deposition still widely emanates from studies under self-similar, isotropic wall motions. Building on recent 3D models of multi-generation acinar networks, we explore in numerical simulations how different hypothesized scenarios of anisotropic expansion influence deposition outcomes of inhaled aerosols in the acinar depths. While the broader range of particles acknowledged to reach the acinar region (d(p) = 0.005-5.0 mu m) are largely unaffected by the details of anisotropic expansion under tidal breathing, our results suggest nevertheless that anisotropy modulates the deposition sites and fractions for a narrow band of sub-micron particles (d(p) similar to 0.5-0.75 mu m), where the fate of aerosols is greatly intertwined with local convective flows. Our findings underscore how intrinsic aerosol motion (i.e. diffusion, sedimentation) undermines the role of anisotropic wall expansion that is often attributed in determining aerosol mixing and acinar deposition. (C) 2016 Elsevier Ltd. All rights reserved.
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