期刊
CANCER MEDICINE
卷 11, 期 16, 页码 3074-3083出版社
WILEY
DOI: 10.1002/cam4.4675
关键词
autoimmunity; cancer; immune checkpoint inhibitor therapy; immune-related adverse events; monoclonal antibodies
类别
资金
- Austrian Science Fund [T1112-B]
- Austrian Science Fund (FWF) [T1112] Funding Source: Austrian Science Fund (FWF)
This prospective study aimed to evaluate the association between autoantibodies in the serum of cancer patients and immune-checkpoint inhibitor (ICI) therapy response and immune-related adverse events (irAEs). The results showed that there was no significant association between the presence of autoantibodies and treatment efficacy or higher grade irAEs, neither at treatment start nor after 8-12 weeks of ICI treatment.
Background The presence of autoantibodies in the serum of cancer patients has been associated with immune-checkpoint inhibitor (ICI) therapy response and immune-related adverse events (irAEs). A prospective evaluation of different autoantibodies in different cancer entities is missing. Materials and Methods In this prospective cohort study, we included a pan-cancer cohort of patients undergoing ICI treatment and measured a comprehensive panel of autoantibodies at treatment start and at the time point of first response evaluation. The presence and induction of autoantibodies (ANA, ENA, myositis, hepatopathy, rheumatoid arthritis) in different cancer entities were assessed and the association between autoantibodies and disease control rate (DCR), objective response rate (ORR), and progression-free survival (PFS), as well as the development of grade 3 or higher irAEs were evaluated by logistic regression models, cox proportional hazard models, and Kaplan-Meier estimators. Results Of 44 patients with various cancer entities, neither the presence of any positive autoantibody measurement nor the presence of positive antinuclear antibodies (ANA) [>= 1:80] at baseline was associated with the examined clinical endpoints (DCR, ORR, PFS) in univariable and multivariable analyses. After 8-12 weeks of ICI treatment, DCR, ORR, and PFS did not significantly differ between patients with and without any positive autoantibody measurement or positive ANA titers. The frequency of irAEs did not differ depending on autoantibody status of the patients. Conclusion Autoantibodies at treatment initiation or induction after 8-12 weeks of ICI treatment are not associated with treatment efficacy as indicated by DCR, ORR, and PFS or higher grade irAEs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据