4.6 Review

Checkpoint inhibitor/interleukin-based combination therapy of cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, Research & Experimental

Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications

Jamal Majidpoor et al.

Summary: This review focuses on the role of IL-6 in patients with SARS-CoV-2 infection and cancer, discussing the effectiveness of IL-6 inhibition therapy and the related pathophysiological processes.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Review Oncology

(Im)maturity in Tumor Ecosystem

Keywan Mortezaee et al.

Summary: The immaturity of cells in tumors and the cellular tumor ecosystem plays a significant role in cancer progression. Understanding the mechanisms behind this immaturity can lead to new therapeutic approaches in cancer treatment.

FRONTIERS IN ONCOLOGY (2022)

Review Cell Biology

Redox tolerance and metabolic reprogramming in solid tumors

Keywan Mortezaee

Summary: Tumor cells need to acquire characteristics more potent than normal cells in order to survive and grow in the host environment. This includes having stronger redox tolerance and adaptive metabolic processes. Without these characteristics, tumors are prone to disruption.

CELL BIOLOGY INTERNATIONAL (2021)

Review Oncology

Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives

Keywan Mortezaee et al.

Summary: Radiotherapy is a common treatment for cancer patients, but modulation of the immune system is crucial for treatment outcomes. Immune checkpoint inhibitors have shown promise as an adjuvant therapy to enhance anti-tumor immunity.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Review Medicine, Research & Experimental

The impact of hypoxia on immune state in cancer

Keywan Mortezaee et al.

Summary: Hypoxia in the tumor microenvironment plays a significant role in suppressing the infiltration and activity of CD8(+) T cells, while enhancing the activities of regulatory T cells and myeloid-derived suppressor cells. This hypoxic environment also impairs the maturation and function of dendritic cells and natural killer cells, highlighting the importance of modulating hypoxia as a complementary strategy to immune checkpoint inhibitor therapy.

LIFE SCIENCES (2021)

Article Oncology

Pegilodecakin as monotherapy or in combination with anti-PD-1 or tyrosine kinase inhibitor in heavily pretreated patients with advanced renal cell carcinoma: Final results of cohorts A, G, H and I of IVY Phase I study

Nizar M. Tannir et al.

Summary: IL-10 has anti-inflammatory and CD8+ T-cell-stimulating properties. Pegilodecakin shows promising activity in aRCC with manageable toxicity, and combination with pazopanib or anti-PD-1 inhibitors also demonstrates clinical activity. In the IVY study, pegilodecakin in combination with anti-PD-1 inhibitors shows potential clinical activity.

INTERNATIONAL JOURNAL OF CANCER (2021)

Review Immunology

The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives

Jamal Majidpoor et al.

Summary: The interaction between PD-L1 and PD-1 is crucial for immune evasion in cancers, with PD-L1 positivity generally associated with higher responses to immune checkpoint inhibition (ICI) but also poor prognosis. Triple negative breast cancer (TNBC) is aggressive, but shows meaningful responses to ICI. Combining anti-PD-1/PD-L1 with immune modulatory drugs has shown significant clinical benefits.

CLINICAL IMMUNOLOGY (2021)

Review Oncology

Organ tropism in solid tumor metastasis: an updated review

Keywan Mortezaee

Summary: Tumors of solid organs have a tendency to metastasize to specific organs, relying on the plasticity of tumor cells to reshape their epigenetic landscape and successfully colonize new areas.

FUTURE ONCOLOGY (2021)

Article Multidisciplinary Sciences

A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy

Eric J. Hsu et al.

Summary: This study introduces an IL-2 prodrug, ProIL2, which is selectively activated inside tumors by tumor-associated enzymes. By specifically targeting the tumor microenvironment, ProIL2 effectively promotes anti-tumor immune response while minimizing systemic toxicity, overcoming limitations of traditional IL-2 based immunotherapy.

NATURE COMMUNICATIONS (2021)

Review Oncology

Angiogenesis as a hallmark of solid tumors-clinical perspectives

Jamal Majidpoor et al.

Summary: Angiogenesis is a crucial step in tumorigenesis, with abnormal tumor vasculature leading to hypoxia and acidity in the tumor microenvironment, enhancing tumor aggression. High interstitial fluid pressure can act as a barrier for drug delivery, contributing to tumor resistance to therapy. Combination of anti-angiogenesis therapy with other modalities is a promising strategy for advanced cancers.

CELLULAR ONCOLOGY (2021)

Review Cell Biology

Normalization in tumor ecosystem: Opportunities and challenges

Keywan Mortezaee

Summary: Current research in cancer therapy focuses on reversing abnormalities within the tumor stroma by strategies such as vascular normalization, metabolic modulation, balancing cellular dispersion, and pH and O-2 delivery balance to restore the ecosystem balance for long-lasting effects on tumors.

CELL BIOLOGY INTERNATIONAL (2021)

Review Pharmacology & Pharmacy

Expressivity of Interleukin-8 and Gastric Cancer Prognosis Susceptibility: A Systematic Review and Meta-Analysis

Zhenzhen Wang et al.

Summary: High expression of IL-8 is associated with poor prognosis in gastric cancer patients, with a hazard ratio of 2.08 (95% CI: 1.81-2.39). The sensitivity analysis confirmed the stability of the pooled hazard ratio, and there was no significant publication bias detected in the funnel plots. High IL-8 expression could serve as a negative prognostic biomarker for patients with gastric cancer.

DOSE-RESPONSE (2021)

Article Immunology

Interleukin-2 therapy of cancer-clinical perspectives

Jamal Majidpoor et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Medicine, Research & Experimental

Myeloid-derived suppressor cells in cancer immunotherapy-clinical perspectives

Keywan Mortezaee

Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature immune cells that significantly increase in cancer patients, releasing factors that impact tumor-related events such as metastasis and immune evasion, and can serve as an indicator of tumor prognosis. They can be targeted in combination with current immunotherapies to enhance the immune system's response against tumors.

LIFE SCIENCES (2021)

Article Immunology

Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1

Victor Cervera-Carrascon et al.

Summary: Immune checkpoint inhibitors have revolutionized oncology, but most patients do not benefit from them. Using virotherapy to enhance T-cell activity could improve the efficacy of immune checkpoint inhibitors, even in resistant tumors. The combination of virotherapy with anti-PD-1 therapy led to increased survival in resistant tumors, showing promise in overcoming resistance to immunotherapies.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment

I-Ying Kuo et al.

Summary: Rab37 regulates IL-6 secretion in macrophages to induce M2 polarization, promoting PD-1 expression in CD8(+) T cells. Tumors with high stromal Rab37 and IL-6 levels are associated with immunotherapeutic resistance and poor prognosis in lung cancer patients.

THERANOSTICS (2021)

Article Oncology

Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression

Zoila A. Lopez-Bujanda et al.

Summary: Castration increases IL-8 expression in prostate epithelial cells, leading to infiltration of tumor-promoting PMN-MDSCs, which can be mitigated by blocking IL-8 signaling. Targeting IL-8 signaling in combination with ICB delays castration resistance and increases polyfunctional CD8 T cell density in tumors.

NATURE CANCER (2021)

Article Oncology

IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells

J. M. R. Van der Meer et al.

Summary: N-803 is a promising IL-15-based compound that enhances HPC-NK cell expansion and functionality both in vitro and in vivo. Adding N-803 to HPC-NK cell therapy could potentially improve cancer immunotherapy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Multidisciplinary Sciences

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy

Meenu Sharma et al.

NATURE COMMUNICATIONS (2020)

Review Biotechnology & Applied Microbiology

Significance of the IL-8 pathway for immunotherapy

Manuela Gonzalez-Aparicio et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

Editorial Material Biotechnology & Applied Microbiology

Rationale for IL-15 superagonists in cancer immunotherapy

Karin M. Knudson et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Article Biochemistry & Molecular Biology

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Kobe C. Yuen et al.

NATURE MEDICINE (2020)

Review Medicine, Research & Experimental

Immune escape: A critical hallmark in solid tumors

Keywan Mortezaee

LIFE SCIENCES (2020)

Review Immunology

Localized Interleukin-12 for Cancer Immunotherapy

Khue G. Nguyen et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Multidisciplinary Sciences

Revisiting the PD-1 pathway

Nikolaos Patsoukis et al.

SCIENCE ADVANCES (2020)

Article Oncology

Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade

Chipman R. G. Stroud et al.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2019)

Review Immunology

Targets for improving tumor response to radiotherapy

Keywan Mortezaee et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang et al.

NATURE COMMUNICATIONS (2019)

Review Cell Biology

Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches

Nasser Hashemi Goradel et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy

Keywan Mortezaee et al.

CURRENT MOLECULAR PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

Metformin as a Radiation Modifier; Implications to Normal Tissue Protection and Tumor Sensitization

Keywan Mortezaee et al.

CURRENT CLINICAL PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Role of PD-1 during effector CD8 T cell differentiation

Eunseon Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Meeting Abstract Oncology

Serum interleukin 8 (IL-8) may serve as a biomarker of response to immuno-oncology (I-O) therapy.

Michael Carleton et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Article Oncology

PD-L1 blockade enhances anti-tumor efficacy of NK cells

Jeremiah L. Oyer et al.

ONCOIMMUNOLOGY (2018)

Article Rheumatology

Successful treatment of arthritis induced by checkpoint inhibitors with tocilizumab: a case series

Sang Taek Kim et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Article Biochemistry & Molecular Biology

IL-6 and PD-L1 blockade combination inhibits hepatocellular carcinoma cancer development in mouse model

Hu Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Medicine, Research & Experimental

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

Erin E. West et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Immunology

PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo

Shunsuke Chikuma et al.

JOURNAL OF IMMUNOLOGY (2009)