期刊
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
卷 138, 期 2, 页码 -出版社
ASME
DOI: 10.1115/1.4032128
关键词
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资金
- National Institutes of Health (NIH) [GM083997, HL110335, HL118532, HL120142, CA187692]
- National Science Foundation (NSF) [CMMI-1435853]
- Camille and Henry Dreyfus Foundation
- David & Lucile Packard Foundation
- Burroughs Wellcome Fund
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1435853] Funding Source: National Science Foundation
Cell-generated mechanical forces drive many of the tissue movements and rearrangements that are required to transform simple populations of cells into the complex three-dimensional geometries of mature organs. However, mechanical forces do not need to arise from active cellular movements. Recent studies have illuminated the roles of passive forces that result from mechanical instabilities between epithelial tissues and their surroundings. These mechanical instabilities cause essentially one-dimensional epithelial tubes and two-dimensional epithelial sheets to buckle or wrinkle into complex topologies containing loops, folds, and undulations in organs as diverse as the brain, the intestine, and the lung. Here, I highlight examples of buckling and wrinkling morphogenesis, and suggest that this morphogenetic mechanism may be broadly responsible for sculpting organ form.
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