期刊
ALLERGOLOGY INTERNATIONAL
卷 71, 期 3, 页码 294-300出版社
JAPANESE SOC ALLERGOLOGY
DOI: 10.1016/j.alit.2022.03.002
关键词
Group 2 innate lymphoid cells; IL-33; Neuro-immune interactions; Neurons Type 2 inflammation
资金
- Keio University Academic Development Funds
- Keio Gijuku Fukuzawa Memorial Fund for the Advancement of Education and Research
- Mochida Memorial Foundation for Medical and Pharmaceutical Research, KAKENHI [JP20K17193]
- National Institutes of Health [DK126871, AI151599, AI095466, AI095608, AR070116]
- Crohn's & Colitis Foundation
- LEO Foundation
- Cure for IBD
- Rosanne H. Silbermann Foundation
- Sackler Brain and Spine Institute Research
- Pamela and Arthur Sanders Family Foundation
- Glenn Greenberg and Linda Vester Foundation
The neural and immune systems are closely connected, and neuropeptides have been found to regulate ILC2 cells, which are independent of acquired immunity. However, the complete mechanisms of this regulation are not fully understood yet. This review summarizes the current reports on the regulatory effects of neuropeptides on ILC2 cells, which have conflicting results possibly due to the complexity of G-protein coupled receptors.
The neural and immune systems are closely connected, and recently, their molecular mechanisms and relationships with diseases have attracted substantial attention. Particularly, it has been increasingly reported that ILC2s, which produce type 2 cytokines independent of acquired immunity, are regulated by neuropeptides such as catecholamines, acetylcholine, vasoactive intestinal peptide, neuromedins, and calcitonin gene-related peptide. However, the regulatory mechanisms in this regard are only partially understood, implying that further studies are still needed to clarify the complete mechanisms and processes. In this review, we summarize current reports on the regulatory effect of neuropeptides on ILC2s, some of which have conflicting results, possibly owing to the complexity of G-protein coupled receptors. By summarizing the current evidence, we hope to be able to identify what is currently unknown as well as what needs to be clarified in the future. Copyright (c) 2022, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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