☆ 4.4 Review

Peripheral itch sensitization in atopic dermatitis

ALLERGOLOGY INTERNATIONAL (2022)

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Article Pharmacology & Pharmacy

Glucosylsphingosine evokes pruritus via activation of 5-HT2A receptor and TRPV4 in sensory neurons

Babina Sanjel et al.

Summary: This study provides evidence for a novel molecular signalling pathway for GS-induced pruritus, which involves the activation of both 5-HT2A receptor and TRPV4 in mouse sensory neurons. These findings reveal the molecular mechanism underlying GS-induced itching.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Review Dermatology

Novel functions of S1P in chronic itchy and inflammatory skin diseases

N. Gray et al.

Summary: S1P is a pleiotropic sphingolipid signaling molecule that influences cell fate and immune cell trafficking. Evidence suggests that dysfunction and imbalance of the S1P-axis may contribute to inflammatory skin diseases, while studies on modulators targeting the S1P pathway show promising therapeutic potential.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Allergy

Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV

Eriko Komiya et al.

Summary: This study investigated the peripheral mechanisms of mechanical alloknesis by using CD26/DPPIV knockout mice. The results suggest that EMs induce mechanical alloknesis at the periphery under the enzymatic control of CD26/DPPIV. This study provides important insights into the understanding of the mechanisms underlying mechanical alloknesis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

IL-33 signaling in sensory neurons promotes dry skin itch

Anna M. Trier et al.

Summary: IL-33 signaling may play a critical role in the development of chronic itch, depending on the tissue microenvironment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Dermatology

Specific β-Defensins Stimulate Pruritus through Activation of Sensory Neurons

Pang-Yen Tseng et al.

Summary: The study found that specific beta-defensins may be endogenous pruritogens that can directly stimulate sensory neurons, and that their expression is increased in skin lesions.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Allergy

Mechanistic insights into the antipruritic effects of lebrikizumab, an anti-IL-13 mAb

Yannick Miron et al.

Summary: These preclinical findings indicate that IL-13 plays a direct enhancer role in multiple itch and neuroactive pathways as well as transcriptional downstream effects, providing insights into the mechanistic basis for lebrikizumab's anti-itch effects.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

A basophil-neuronal axis promotes itch

Fang Wang et al.

Summary: The study identifies that a large proportion of patients with atopic dermatitis (AD) harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares. It also shows that in AD-associated inflammation, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares.

CELL (2021)

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Article Allergy

Tick peptides evoke itch by activating MrgprC77/MRGPRX7 to sensitize TRPV7 in pruriceptors

Xueke Li et al.

Summary: This study identified tick salivary peptides as pruritogens that initiate itch through MrgprC11/X1-TRPV1 signaling in pruritoceptors. The findings provide potential drug targets for the prevention and treatment of pruritus induced by tick bites or other arthropods. IPDef1 was found to have a stronger pruritogenic potential than IRDef2 and induced itch in a histamine-independent manner.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation

Sumika Toyama et al.

Summary: Recent studies have shown that non-histaminergic mediators such as proteases, neuropeptides, and cytokines play a role in evoking and modulating itch sensation, acting on sensory nerve fibers in the skin. Understanding the connections between immune cell-derived mediators and sensory nerve fibers has led to the development of new treatments for itch.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Oncostatin M can sensitize sensory neurons in inflammatory pruritus

Pang-Yen Tseng et al.

Summary: The cytokine oncostatin M (OSM) is highly up-regulated in various inflammatory skin diseases and acts as an itch neuromodulator by sensitizing neurons to pruritogens. Antagonism of the OSMR complex effectively alleviates pruritus in experimental inflammatory dermatitis, indicating OSM signal transduction as a potential target for antipruritic therapy.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

Eileen Nguyen et al.

Summary: The study found that morphine-induced itch is caused by neurons rather than mast cells, and spinal dynorphin neurons play an important role in mice. Agonism of the kappa-opioid receptor can alleviate morphine-induced itch, challenging the long-standing use of antihistamines.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Biology

Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

Minh Q. Nguyen et al.

Summary: Through single nuclear transcriptomics of human DRG neurons, it was found that different types of neurons share similarities in their transcriptomic features, but there are species differences in the expression of genes related to sensory function. Surprisingly, several transcriptomic classes without clear equivalents in other species were identified.

ELIFE (2021)

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Article Immunology

Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus

Wook-Joo Lee et al.

Summary: The study reveals that the neuroimmune interactions of TSLP and TRPV4 play key roles in dry skin-induced pruritus. Treatment with a TRPV4 antagonist or knockout of the Trpv4 gene can alleviate dry skin symptoms and itching.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Medicine, General & Internal

The Pathology of Type 2 Inflammation-Associated Itch in Atopic Dermatitis

Catharina Sagita Moniaga et al.

Summary: Recent evidence on type 2 inflammation-associated itch in atopic dermatitis has been reported, highlighting the importance of neuroimmune interactions in research. Understanding bidirectional neuroimmune interactions is crucial in gaining insights into the pathogenesis of itch and its treatment. Improved management and treatment options for itch in atopic dermatitis are being explored through novel and targeted biologic agents in advanced clinical trials.

DIAGNOSTICS (2021)

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Article Multidisciplinary Sciences

The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch

Tiphaine Voisin et al.

Summary: This study uncovered the role of LTC4 and its receptor CysLT(2)R in inducing itch, providing a promising approach for treating inflammatory itch. The research highlights the importance of targeting CysLT signaling in managing inflammatory itch.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Anesthesiology

Evaluation of Therapies for Peripheral and Neuraxial Opioid-induced Pruritus based on Molecular and Cellular Discoveries

Eileen Nguyen et al.

Summary: Opioids are commonly used for pain management worldwide, but their side effect of pruritus limits their clinical use. This review discusses the mechanisms and clinical management of opioid-induced pruritus, highlighting recent discoveries and emerging therapies such as selective kappa-opioid receptor agonists.

ANESTHESIOLOGY (2021)

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Article Dermatology

Possible involvement of type 2 cytokines in alloknesis in mouse models of menopause and dry skin

Nao Ichimasu et al.

Summary: The phenomenon of alloknesis, an abnormal itch sensation induced by innocuous stimuli, is a key aspect in the itch-scratch cycle in patients with atopic dermatitis. Dry skin and pruritus, including alloknesis, are significant issues in peri- and post-menopausal women. Research has shown that impaired barrier function, in combination with type 2 cytokines from eosinophils and basophils in the skin, could trigger the development of alloknesis, suggesting potential therapeutic targets for sensitive skin.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Dermatology

The pruritogenic role of the type 2 immune response in diseases associated with chronic itch

Giuseppe Ingrasci et al.

Summary: While the etiologies of chronic pruritus are diverse, recent research suggests that there are similar interactions between keratinocytes, nerves, and the immune system in many conditions. The type 2 immune response, involving Th2 T Cells and related cytokines, plays a significant role in the development of pruritus in various itchy conditions. Atopic dermatitis is a prominent example, but the evidence supporting its role in other itchy conditions is growing, with new treatments targeting this immune system pathway being developed.

EXPERIMENTAL DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch

Jenny Wilzopolski et al.

Summary: The study found that both TRPV1 and TRPA1 channels play important roles in the transmission of histamine-induced itch, with TRPV1 inhibition reducing itch induced by both H1R and H4R, while TRPA1 inhibition only reduced H4R-induced itch. In vitro experiments showed that inhibition of TRPV1 and TRPA1 led to reduced Ca2+ influx into sensory neurons.

BIOMOLECULES (2021)

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Review Neurosciences

Neural Mechanisms of Itch

Mark Lay et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 43 (2020)

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Review Physiology

PHYSIOLOGY AND PATHOPHYSIOLOGY OF ITCH

Ferda Cevikbas et al.

PHYSIOLOGICAL REVIEWS (2020)

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Editorial Material Neurosciences

Nociceptor-Mast Cell Sensory Clusters as Regulators of Skin Homeostasis

James Meixiong et al.

TRENDS IN NEUROSCIENCES (2020)

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Article Cell Biology

Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch

Santosh K. Mishra et al.

CELL REPORTS (2020)

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Article Medicine, General & Internal

Atopic dermatitis

Sinéad M Langan et al.

LANCET (2020)

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Article Neurosciences

Posterior Thalamic Nucleus Mediates Facial Histaminergic Itch

Ya-Bing Zhu et al.

NEUROSCIENCE (2020)

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Review Multidisciplinary Sciences

Central circuit mechanisms of itch

Xiao-Jun Chen et al.

NATURE COMMUNICATIONS (2020)

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Review Neurosciences

How Do Sensory Neurons Sense Danger Signals?

Christopher R. Donnelly et al.

TRENDS IN NEUROSCIENCES (2020)

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Review Dermatology

Mechanisms and Management of Itch in Dry Skin

Catharina Sagita Moniaga et al.

ACTA DERMATO-VENEREOLOGICA (2020)

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Review Dermatology

The Challenge of Basic Itch Research

Earl Carstens et al.

ACTA DERMATO-VENEREOLOGICA (2020)

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Article Allergy

Beta-defensins are proinflammatory pruritogens that activate Mrgprs

Li Zhang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development

Sonoko Takahashi et al.

SCIENTIFIC REPORTS (2019)

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Article Dermatology

Addiction and the itch-scratch cycle. What do they have in common?

Yozo Ishiuji

EXPERIMENTAL DERMATOLOGY (2019)

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Review Neurosciences

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

Hanna Siiskonen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Allergy

Selective role of neurokinin B in IL-31-induced itch response in mice

Daiji Sakata et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Dermatology

Interleukin-33 in atopic dermatitis

Yasutomo Imai

JOURNAL OF DERMATOLOGICAL SCIENCE (2019)

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Article Immunology

House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation

Nadine Serhan et al.

NATURE IMMUNOLOGY (2019)

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Letter Dermatology

3-Dimensional Optical Clearing and Imaging of Pruritic Atopic Dermatitis and Psoriasis Skin Reveals Downregulation of Epidermal Innervation

Yingrou Tan et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Peripheral Vascular Disease

Endothelin: 30 Years From Discovery to Therapy

Matthias Barton et al.

HYPERTENSION (2019)

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Review Dermatology

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

Gil Yosipovitch et al.

ACTA DERMATO-VENEREOLOGICA (2019)

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Review Medicine, General & Internal

Itch Processing in the Skin

Martin Schmelz

FRONTIERS IN MEDICINE (2019)

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Article Dermatology

Attenuated Activation of Homeostatic Glucocorticoid in Keratinocytes Induces Alloknesis via Aberrant Artemin Production

Akira Matsumoto et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Neurosciences

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

Qingjian Han et al.

NEURON (2018)

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Article Behavioral Sciences

The vicious cycle of itch and anxiety

Kristen M. Sanders et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

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Article Cell Biology

Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice

Admire Munanairi et al.

CELL REPORTS (2018)

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Article Neurosciences

S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways

Rose Z. Hill et al.

JOURNAL OF NEUROSCIENCE (2018)

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Article Neurosciences

Kappa Opioid Receptor Distribution and Function in Primary Afferents

Lindsey M. Snyder et al.

NEURON (2018)

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Review Immunology

The Itch-Scratch Cycle: A Neuroimmune Perspective

Madison R. Mack et al.

TRENDS IN IMMUNOLOGY (2018)

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Review Immunology

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Simon A. Jones et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Immunology

The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin

Takanori Hidaka et al.

NATURE IMMUNOLOGY (2017)

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Article Allergy

Substance P activates Mas-related G protein-coupled receptors to induce itch

Ehsan Azimi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Review Allergy

Therapeutic pipeline for atopic dermatitis: End of the drought?

Amy S. Paller et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Neurosciences

Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin

F. Ru et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

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Article Multidisciplinary Sciences

A central neural circuit for itch sensation

Di Mu et al.

SCIENCE (2017)

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Article Multidisciplinary Sciences

Distinct roles of NMB and GRP in itch transmission

Li Wan et al.

SCIENTIFIC REPORTS (2017)

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Article Dermatology

Involvement of mu-opioid Receptors and kappa-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Nobuaki Takahashi et al.

ACTA DERMATO-VENEREOLOGICA (2017)

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Article Dermatology

Involvement of Leukotriene B-4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice

Tsugunobu Andoh et al.

ACTA DERMATO-VENEREOLOGICA (2017)

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Article Biochemistry & Molecular Biology

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Landon K. Oetjen et al.

CELL (2017)

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Article Biochemistry & Molecular Biology

Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway

Ramsha Afzal et al.

BIOMOLECULES & THERAPEUTICS (2017)

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Letter Dermatology

Numerical and comparative three-dimensional structural analysis of peripheral nerve fibres in epidermis of patients with atopic dermatitis

M. Tsutsumi et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

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Review Allergy

Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?

Nicholas K. Mollanazar et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

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Review Allergy

The role of human β-defensins in allergic diseases

F. Niyonsaba et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

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Letter Dermatology

Topical nalfurafine exhibits anti-inflammatory and anti-pruritic effects in a murine model of AD

Graham Elliott et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

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Article Multidisciplinary Sciences

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy

Boyi Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Allergy

Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis

M. K. Aktar et al.

ALLERGY (2015)

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Article Neurosciences

Intradermal endothelin-1 excites bombesin-responsive superficial dorsal horn neurons in the mouse

T. Akiyama et al.

JOURNAL OF NEUROPHYSIOLOGY (2015)

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Article Neurosciences

HTR7 Mediates Serotonergic Acute and Chronic Itch

Takeshi Morita et al.

NEURON (2015)

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Article Anesthesiology

A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch

Tasuku Akiyama et al.

PAIN (2015)

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Article Neurosciences

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

Dmitry Usoskin et al.

NATURE NEUROSCIENCE (2015)

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Article Allergy

Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis

Peter M. Elias et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Medicine, Research & Experimental

Neural peptidase endothelin-converting enzyme 1-regulates endothelin induced pruritus

Makiko Kido-Nakahara et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Review Dermatology

Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications

Mitsutoshi Tominaga et al.

JOURNAL OF DERMATOLOGY (2014)

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Article Dermatology

The Excimer Lamp Induces Cutaneous Nerve Degeneration and Reduces Scratching in a Dry-Skin Mouse Model

Atsuko Kamo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Article Neurosciences

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Adam P. Kardon et al.

NEURON (2014)

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Review Allergy

Periostin in Allergic Inflammation

Kenji Izuhara et al.

ALLERGOLOGY INTERNATIONAL (2014)

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Article Pharmacology & Pharmacy

An Update on Peripheral Mechanisms and Treatments of Itch

Mitsutoshi Tominaga et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)

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Article Biochemistry & Molecular Biology

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Sarah R. Wilson et al.

CELL (2013)

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Review Dermatology

New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity

Kenji Kabashima

JOURNAL OF DERMATOLOGICAL SCIENCE (2013)

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Article Neurosciences

A subpopulation of nociceptors specifically linked to itch

Liang Han et al.

NATURE NEUROSCIENCE (2013)

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Review Neurosciences

NEURAL PROCESSING OF ITCH

Tasuku Akiyama et al.

NEUROSCIENCE (2013)

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Article Allergy

Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis

Hiroyuki Murota et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Dermatology

Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis

Osamu Negi et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2012)

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Article Dermatology

Mouse Model of Touch-Evoked Itch (Alloknesis)

Tasuku Akiyama et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Article Medicine, Research & Experimental

Endothelin-1 induces itch and pain in the mouse cheek model

Lenyta Oliveira Gomes et al.

LIFE SCIENCES (2012)

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Article Neurosciences

CROSS-SENSITIZATION OF HISTAMINE-INDEPENDENT ITCH IN MOUSE PRIMARY SENSORY NEURONS

T. Akiyama et al.

NEUROSCIENCE (2012)

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Article Neurosciences

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

Tong Liu et al.

NEUROSCIENCE BULLETIN (2012)

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Article Dermatology

Modulation of semaphorin 3A expression by calcium concentration and histamine in human keratinocytes and fibroblasts

Shoko Fukamachi et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2011)

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Article Dermatology

Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice

Atsuko Kamo et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2011)

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Article Dermatology

Matrix Metalloproteinase-8 Is Involved in Dermal Nerve Growth: Implications for Possible Application to Pruritus from In Vitro Models

Mitsutoshi Tominaga et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

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Article Neurosciences

A Role for Nociceptive, Myelinated Nerve Fibers in Itch Sensation

Matthias Ringkamp et al.

JOURNAL OF NEUROSCIENCE (2011)

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Article Neurosciences

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

Sarah R. Wilson et al.

NATURE NEUROSCIENCE (2011)

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Article Neurosciences

Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1

Jiexian Liang et al.

NEUROSCIENCE LETTERS (2011)

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Review Pharmacology & Pharmacy

New perspectives on the endothelin axis in pain

Travis P. Barr et al.

PHARMACOLOGICAL RESEARCH (2011)

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Editorial Material Allergy

Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases

H. Murota et al.

ALLERGY (2010)

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Article Medicine, Research & Experimental

Molecular signaling of pruritus induced by endothelin-1 in mice

Jiexian Liang et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2010)

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Article Dermatology

Keratinocyte-derived anosnnin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis

Suhandy Tengara et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2010)

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Article Neurosciences

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

Sarah E. Ross et al.

NEURON (2010)

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Article Anesthesiology

Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch

T. Akiyama et al.

PAIN (2010)

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Article Dermatology

In vitro model for penetration of sensory nerve fibres on a Matrigel basement membrane: implications for possible application to intractable pruritus

M. Tominaga et al.

BRITISH JOURNAL OF DERMATOLOGY (2009)

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Article Pharmacology & Pharmacy

Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5′-guanidinonaltrindole-induced scratching models in mice: Behavioral and neuroanatomical evidence

Saadet Inan et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

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Article Allergy

The histamine H4 receptor is functionally expressed on TH2 cells

Ralf Gutzmer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Dermatology

Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis

Mitsutoshi Tominaga et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2009)

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Article Immunology

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Akiharu Kubo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

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Letter Dermatology

Histological Characterization of Cutaneous Nerve Fibers Containing Gastrin-Releasing Peptide in NC/Nga Mice: An Atopic Dermatitis Model

Mitsutoshi Tominaga et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

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Article Multidisciplinary Sciences

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

Noritaka Imamachi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Letter Dermatology

Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis

M. Tominaga et al.

BRITISH JOURNAL OF DERMATOLOGY (2008)

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Review Allergy

Skin barrier function

Peter M. Elias

CURRENT ALLERGY AND ASTHMA REPORTS (2008)

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Letter Allergy

Correlation of IL-31 serum levels with severity of atopic dermatitis

Ulrike Raap et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

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Review Biotechnology & Applied Microbiology

The role of histamine H-1 and H-4 receptors in allergic inflammation: The search for new antihistamines

Robin L. Thurmond et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

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Review Endocrinology & Metabolism

Endothelin-1-induced pain and hyperalgesia: A review of pathophysiology, clinical manifestations and future therapeutic options

Guy Hans et al.

NEUROPEPTIDES (2008)

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Article Dermatology

Rapid changes in substance P signaling and neutral endopeptidase induced by skin-scratching stimulation in mice

Junichi Yamaoka et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2007)

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Article Dermatology

Intraepidermal nerve fibers increase in dry skin of acetone-treated mice

Mitsutoshi Tominaga et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2007)

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Article Dermatology

Possible roles of epidermal opioid systems in pruritus of atopic dermatitis

Mitsutoshi Tominaga et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

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Article Dermatology

Treatment of pruritus with topically applied opiate receptor antagonist

Paul L. Bigliardi et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2007)

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Article Pharmacology & Pharmacy

Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice

D. S. McQueen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

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Article Neurosciences

TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase

Won-Sik Shim et al.

JOURNAL OF NEUROSCIENCE (2007)

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Review Immunology

The skin barrier as an innate immune element

Peter M. Elias

SEMINARS IN IMMUNOPATHOLOGY (2007)

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Article Dermatology

A hypothetical mechanism of intraepidermal neurite formation in NC/Nga mice with atopic dermatitis

Mitsutoshi Tominaga et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2007)

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Review Cell Biology

Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Article Anesthesiology

Bradykinin is a potent pruritogen in atopic dermatitis: A switch from pain to itch

Miwa Hosogi et al.

PAIN (2006)

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Article Neurosciences

Phospholipase Cβ3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons

Sang-Kyou Han et al.

NEURON (2006)

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Review Neurosciences

The neurobiology of itch

Akihiko Ikoma et al.

NATURE REVIEWS NEUROSCIENCE (2006)

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Article Dermatology

Involvement of IL-31 on scratching behavior in NC/Nga mice with atopic-like dermatitis

A Takaoka et al.

EXPERIMENTAL DERMATOLOGY (2006)

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Article Allergy

IL-31: A new link between T cells and pruritus in atopic skin inflammation

E Sonkoly et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Detection of kappa and delta opioid receptors in skin -: Outside the nervous system

S Salemi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Clinical Neurology

Painful stimuli evoke itch in patients with chronic pruritus - Central sensitization for itch

A Ikoma et al.

NEUROLOGY (2004)

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Article Neurosciences

Histamine-induced Ca2+ influx via the PLA2/lipoxygenase/TRPV1 pathway in rat sensory neurons

BM Kim et al.

NEUROSCIENCE LETTERS (2004)

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Article Physiology

Effects of eosinophils on nerve cell morphology and development: the role of reactive oxygen species and p38 MAP kinase

PJ Kingham et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)

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Article Pharmacology & Pharmacy

Activation of κ-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys

MCH Ko et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

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