期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 27, 期 18, 页码 1808-1823出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2016.1237452
关键词
pH-Responsive; alginate hydrogel; drug delivery system; solution extrusion; controlled drug release
资金
- National Natural Science Foundation of China [21174091, 51303111]
- Funds for Doctoral Disciplines of The Ministry of Education of China [20130181120122]
- Applied Basic Research Foundation of Sichuan Province [2014JY0131]
Homogeneous alginate hydrogels were facilely fabricated through solution extrusion process. CaCO3 and D-glucono--lactone (GDL) were used as the gelation agents. The slow gelation of alginate was realized by the in-situ release of Ca2+ from CaCO3 particles induced by hydrolysis of GDL to reduce pH. Slight gelation during the extrusion caused the enhanced strength of the alginate solutions, leading to the extrudability of the blends. This method enables to produce alginate hydrogels in a single step via extrusion, which is economically advantageous to conventional lab-scale preparation for mass production. Three different drugs, ibuprofen, acetaminophen, and methylthionine chloride, were used as model drugs to evaluate the drug release behavior of the alginate hydrogels. It was demonstrated that the drug release behavior was significantly adjusted by both the drug solubility and the ionic interaction between alginate and the drug molecule. It was shown that solution extrusion process is a feasible method to produce alginate-based drug delivery systems.
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