期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 31, 期 1, 页码 140-151出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328216633892
关键词
Hydroxyapatite; co-substitution; cation leach liquor; crystallinity; biocompatibility
资金
- National Natural Science Foundation of China [31370970]
- Research Fund for the Doctoral Program of Higher Education of China [20130032110003]
- Tianjin Research Program of Application Foundation and Advanced Technology [13JCZDJC33300, 14JCZDJC38500]
The present study aims to investigate the contribution of two biologically important cations, Mg2+ and Sr2+, when co-substituted into the structure of hydroxyapatite (Ca-10(PO4)(6)(OH)(2), HA). The substituted samples were synthesized by a hydrothermal method that involved the addition of Mg2+ and Sr2+ containing precursors to partially replace Ca2+ in the apatite structure. Four co-substituted HA samples with different concentrations of Mg2+ and Sr2+ ((Mg+Sr)/(Mg+Sr+Ca)=30%) were investigated, and they were compared with pure HA. Experimental results showed that only a limited amount of Mg (Mg/(Mg+Ca+Sr)<14%) could successfully substitute for Ca in HA. In addition, Mg substitution resulted in reduced crystallinity, thermal stability and lattice parameters of HA. In contrast, Sr could fully substitute for Ca. Furthermore, the addition of Sr increased the lattice parameters of HA. Here, we obtained the cation leach liquor by immersing the prepared samples in a culture medium for cell experiments. The invitro study showed that 10Mg20Sr promoted better MG63 cell attachment, proliferation and differentiation than HA. Thus, the presence of an appropriate proportion of Mg and Sr could play a significant role in the increased biocompatibility of HA.
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