期刊
MEDICAL SCIENCE MONITOR
卷 28, 期 -, 页码 -出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.936292
关键词
Anti-Inflammatory Agents; Non-Steroidal; COVID-19; Flavonoids; Hesperidin; Indomethacin; Quercetin
The COVID-19 pandemic has led to research on antiviral treatments and vaccines, and there is a need to identify drugs that can treat and prevent the progression of the disease. Understanding the molecular mechanisms of SARS-CoV-2 infection is crucial for the development of effective therapies.
In the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has driven investigational studies and controlled clinical trials on antiviral treatments and vaccines that have undergone regulatory approval. Now that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants may become endemic over time, there remains a need to identify drugs that treat the symptoms of COVID-19 and prevent progression toward severe cases, hospitalization, and death. Understanding the molecular mechanisms of SARS-CoV-2 infection is extremely important for the development of effective therapies against COVID-19. This review outlines the key pathways involved in the host response to SARS-CoV-2 infection and discusses the potential role of antioxidant and anti-inflammatory pharmacological approaches for the management of early mild-to -moderate COVID-19, using the examples of combined indomethacin, low-dose aspirin, omeprazole, hesperidin, quercetin, and vitamin C. The pharmacological targets of these substances are described here for their possible synergism in counteracting SARS-CoV-2 replication and progression of the infection from the upper respiratory airways to the blood, avoiding vascular complications and cytokine and bradykinin storms.
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