4.4 Article

Spectacle Lenses With Aspherical Lenslets for Myopia Control vs Single-Vision Spectacle Lenses A Randomized Clinical Trial

期刊

JAMA OPHTHALMOLOGY
卷 140, 期 5, 页码 472-478

出版社

AMER MEDICAL ASSOC
DOI: 10.1001/jamaophthalmol.2022.0401

关键词

-

资金

  1. International S&T Cooperation Program of China [2014DFA30940]
  2. Essilor International (Wenzhou Medical University) [95013006, 95016010, 95020005]

向作者/读者索取更多资源

This study found that spectacle lenses with higher lenslet asphericity, especially when worn for longer periods of time, can effectively reduce myopia progression and axial elongation over a two-year period.
IMPORTANCE Reducing myopia progression can reduce the risk of associated ocular pathologies. OBJECTIVE To evaluate whether spectacle lenses with higher lenslet asphericity have a higher myopia control efficacy throughout 2 years. DESIGN, SETTING. AND PARTICIPANTS This double-masked randomized clinical trial was conducted between July 2018 and October 2020 at the Eye Hospital of Wenzhou Medical University in Wenzhou, China. Children aged 8 to 13 years with a cycloplegic spherical equivalent refraction (SER) of -0.75 D to -4.75 D and astigmatism with less than -1.50 D were recruited. A data and safety monitoring committee reviewed findings from a planned interim analysis in 2019. INTERVENTIONS Participants were randomly assigned in a 1:1:1 ratio to receive spectacle lenses with highly aspherical lenslets (HAL), spectacle lenses with slightly aspherical lenslets (SAL), or single-vision spectacle lenses (SVL). MAIN OUTCOME AND MEASURES Two-year changes in SER and axial length and their differences between groups. RESULTS Of 157 participants who completed each visit (mean [SD] age, 10.4 [1.2] years), 54 were analyzed in the HAL group, 53 in the SAL group, and 50 in the SVL group. Mean (SE) 2-year myopia progression in the SVL group was 1.46 (0.09) D. Compared with SVL, the mean (SE) change in SER was less for HAL (by 0.80 [0.11] D) and SAL (by 0.42 [0.11] D; P <= .001). The mean (SE) increase in axial length was 0.69 (0.04) mm for SVL. Compared with SVL, increase in axial length was slowed by a mean (SE) of 0.35 (0.05) mm for HAL and 0.18 (0.05) mm for SAL (P <= .001). Compared with SVL, for children who wore HAL at least 12 hours every day, the mean (SE) change in SER was slowed by 0.99 (0.12) D, and increase in axial length slowed by 0.41 (0.05) mm. CONCLUSIONS AND RELEVANCE In this study, HAL and SAL reduced the rate of myopia progression and axial elongation throughout 2 years, with higher efficacy for HAL. Longer wearing hours resulted in better myopia control efficacy for HAL.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据