期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 291, 期 13, 页码 6714-6722出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R115.692020
关键词
cAMP response element-binding protein (CREB); hypoxia-inducible factor (HIF); intrinsically disordered protein; protein-protein interaction; STAT transcription factor; structure-function; transcriptional coactivator; coupled folding and binding; intrinsically disordered region; viral oncoprotein; IDP; IDR; transcriptional activation
资金
- National Institutes of Health [GM113251, CA096865]
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a particularly rich set of interactions with disordered and partly ordered partners, as a part of their ubiquitous role in facilitating transcription of genes. CBP and p300 contain a number of small structured domains that provide scaffolds for the interaction of disordered transactivation domains from a wide variety of partners, including p53, hypoxia-inducible factor 1 (HIF-1), NF-B, and STAT proteins, and are the targets for the interactions of disordered viral proteins that compete with cellular factors to disrupt signaling and subvert the cell cycle. The functional diversity of the CBP/p300 interactome provides an excellent example of the power of intrinsic disorder to facilitate the complexity of living systems.
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