Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine

As a natural product with various biological activities, triptolide (TP) has been reported in anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic window, poor water solubility, and fast metabolism limit its wide clinical application. To reduce its adverse effects and enhance its efficacy, research and design of targeted drug delivery systems (TDDS) based on nanomaterials is one of the most viable strategies at present. This review summarizes the reports and studies of TDDS combined with TP in recent years, including passive and active targeting of drug delivery systems, and specific delivery system strategies such as polymeric micelles, solid lipid nanoparticles, liposomes, and stimulus-responsive polymer nanoparticles. The reviewed literature presented herein indicates that TDDS is a multifunctional and efficient method for the delivery of TP. In addition, the advantages and disadvantages of TDDS are sorted out, aiming to provide reference for the combination of traditional Chinese medicine and advanced nano drug delivery systems (NDDS) in the future.

Automated summary

Triptolide (TP) is a natural product with various biological activities, but its narrow therapeutic window, poor water solubility, and fast metabolism limit its clinical application. To overcome these limitations, targeted drug delivery systems (TDDS) based on nanomaterials have been developed. This review summarizes recent studies on TDDS combined with TP, highlighting the potential of TDDS as a multifunctional and efficient method for delivering TP.