期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 291, 期 33, 页码 16927-16935出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R116.733899
关键词
eukaryotic translation initiation; stress response; translation; translation control; translation regulation
资金
- National Institutes of Health Grant [GM049164]
- Ralph W. and Grace M. Showalter Research Trust Fund
Translation regulation largely occurs during initiation, which features ribosome assembly onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) located in the 5-leader of the mRNA can be selected for translation. Multiple transcripts associated with stress amelioration are preferentially translated through uORF-mediated mechanisms during activation of the integrated stress response (ISR) in which phosphorylation of the subunit of eIF2 results in a coincident global reduction in translation initiation. This review presents key features of uORFs that serve to optimize translational control that is essential for regulation of cell fate in response to environmental stresses.
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