4.4 Article

RNA-Binding Proteins and Alternative Splicing Genes Are Coregulated in Human Retinal Endothelial Cells Treated with High Glucose

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

Genome-Wide Identification of Immune-Related Alternative Splicing and Splicing Regulators Involved in Abdominal Aortic Aneurysm

Shiyong Wu et al.

Summary: The study utilized bioinformatics methods to investigate immune-related genes and immune-RAS in AAA. The findings suggest that immune-related genes, immune-RAS, and splicing factors play significant roles in AAA.

FRONTIERS IN GENETICS (2022)

Review Cell Biology

Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases

Jee-San Lee et al.

Summary: Microexons are small-sized exons that undergo extensive alternative splicing, especially in neurons, microglia, embryonic stem cells, and cancer cells. Including microexons within mRNAs has significant functional consequences in the central nervous system, with dysregulation of their inclusion leading to abnormal processes. The involvement of RNA binding proteins in regulating the inclusion and exclusion of microexons during splicing is crucial for cellular physiology, especially in CNS diseases.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2022)

Review Ophthalmology

Role of small interfering RNA (siRNA) in targeting ocular neovascularization: A review

Shibani Supe et al.

Summary: Ocular neovascularization plays a central role in various ocular diseases, and targeting VEGF with siRNA provides a promising new approach for treatment. The use of ocular anti-VEGF therapy has marked a new era in the treatment of retinal diseases. Delivery methods for siRNA protecting against degradation and suitable for long-term care are key to enhancing the effectiveness of RNAi-based anti-VEGF ocular therapies.

EXPERIMENTAL EYE RESEARCH (2021)

Review Pharmacology & Pharmacy

Molecular basis and therapeutic implications of CD40/CD40L immune checkpoint

TingTing Tang et al.

Summary: The CD40 receptor and its ligand CD40L play a critical role in immune activation, with various therapeutic agents targeting this interaction showing promising clinical efficacy in treating malignancies and autoimmune diseases. The signaling pathways activated by CD40/CD40L interaction lead to immune cell activation and modulation, making it an attractive target for immunotherapy. Ongoing and completed clinical trials have demonstrated the potential of CD40/CD40L-targeted therapy in activating immune responses and treating diseases.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Biochemistry & Molecular Biology

Splice variants of metabolic nuclear receptors: Relevance for metabolic disease and therapeutic targeting

Anna Mukha et al.

Summary: This review discusses the splice variants of metabolic nuclear receptors and their regulation of different metabolic pathways by nutritional signals. These NR splice variants add an intriguing new layer of complexity to metabolic signaling.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Review Biochemistry & Molecular Biology

The Alter Retina: Alternative Splicing of Retinal Genes in Health and Disease

Izarbe Aisa-Marin et al.

Summary: Alternative splicing of mRNA is crucial for regulating and increasing the diversity of transcriptome and proteome. The retina, as an extension of the central nervous system, illustrates the high diversity of neural transcripts with complex splicing programs. Modulation of alternative splicing in the retina is essential for designing novel therapeutic approaches for retinal dystrophies and enabling precision medicine for specific mutations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Genetics & Heredity

Comprehensive Analysis of Cell Population Dynamics and Related Core Genes During Vitiligo Development

Jingzhan Zhang et al.

Summary: This study investigated the relationship between immune cell infiltration and gene expression in vitiligo using bioinformatics methods and expression analysis techniques. The results showed that upregulated genes in skin lesions and peripheral blood of vitiligo patients were enriched in immune response pathways and inflammatory response signaling pathways. The study also found a positive correlation between differentially expressed immune and inflammation response genes and macrophages, CD4+ T cells, and CD8+ T cells in vitiligo patients. The identified genes and pathways may provide new directions for vitiligo treatment.

FRONTIERS IN GENETICS (2021)

Review Cell Biology

Neurodegeneration, Neuroprotection and Regeneration in the Zebrafish Retina

Salvatore L. Stella et al.

Summary: Neurodegenerative retinal diseases lead to gradual loss of retinal neurons, requiring neuroprotective or regenerative strategies for treatment. Zebrafish, due to their similar eye structure and development to mammals, are commonly used as a model for studying these diseases.
Review Genetics & Heredity

Alternative Splicing of Pre-mRNA in the Control of Immune Activity

Zhongjing Su et al.

Summary: Alternative splicing plays a critical role in the regulation of immune cell development and immune activity, with aberrant splicing leading to abnormal immune responses. This review summarizes recent discoveries on immune-associated alternative splice variants, clinical disorders, and regulatory mechanisms.
Article Biochemistry & Molecular Biology

Transthyretin affects the proliferation and migration of human retinal microvascular endothelial cells in hyperglycemia via hnRNPA2B1

Yu Gu et al.

Summary: Transthyretin (TTR) has been shown to suppress neovascularization in diabetic retinopathy by regulating molecules in the STAT-4/miR-223-3p/FBXW7 pathway. The study identified the interaction between TTR and hnRNPA2B1 in retinal microvascular endothelial cells, and proposed a TTR-hnRNPA2B1/STAT-4/miR-223-3p/FBXW7 pathway, providing a theoretical basis for clinical applications.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy

Paras Sehgal et al.

Summary: The study identified a novel vascular endothelial-associated lncRNA named VEAL2, which regulates endothelial permeability and function through interaction with PRKCB2, and is implicated in diabetic retinopathy.

EMBO JOURNAL (2021)

Article Ophthalmology

The potential role of m6A RNA methylation in diabetic retinopathy

Nidhi Kumari et al.

Summary: Diabetic retinopathy, a major microvascular complication of diabetes affecting most individuals, may potentially involve the modification of RNA through m6A in disease progression mechanisms, although its specific role remains unclear.

EXPERIMENTAL EYE RESEARCH (2021)

Article Ophthalmology

Single cell RNA sequencing (scRNA-Seq) deciphering pathological alterations in streptozotocin-induced diabetic retinas

Licheng Sun et al.

Summary: This study decoded the pathological changes of diabetic retinopathy by constructing a transcriptome atlas of diabetic murine retinas, revealing stress-inducible genes, impact on bipolar cells, activation of inflammation pathways in retinal microglia and astrocytes, deregulated genes in diabetic vascular endothelial cells, and the IL-17 signaling pathway activation in diabetic retinal ECs. Additionally, potential targets for diabetic retinopathy therapy were identified.

EXPERIMENTAL EYE RESEARCH (2021)

Review Biochemistry & Molecular Biology

It's not just a phase: function and characteristics of RNA-binding proteins in phase separation

Hannah J. Wiedner et al.

Summary: The organization of RNA in phase-separated condensates provides insights into how sequestration of RNA-binding proteins and RNAs modulates gene expression. This understanding has implications for basic cell biology, the pathogenesis of human diseases, and the development of novel therapies. Biomolecular condensates formed through phase separation play a crucial role in coordinating cellular reactions and regulating various biological phenomena.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

Liu Teng et al.

Summary: The study identified the lncRNA PLANE as a non-protein product of chromosome 3q amplification that promotes tumorigenesis by disrupting the splicing of transcriptional corepressor NCOR2 pre-mRNA.

NATURE COMMUNICATIONS (2021)

Article Pharmacology & Pharmacy

Dysregulated lncRNAs are Involved in the Progress of Sepsis by Constructing Regulatory Networks in Whole Blood Cells

Yanwei Cheng et al.

Summary: In sepsis, the systematic dysregulation of lncRNAs is closely associated with the remodeling of gene expression regulatory network. The lncRNA-mRNA expression network may be utilized to refine biomarker predictions for developing novel therapeutic approaches in sepsis.

FRONTIERS IN PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells

Chiara Bianca Maria Platania et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Calnexin cycle - structural features of the ER chaperone system

Guennadi Kozlov et al.

FEBS JOURNAL (2020)

Article Multidisciplinary Sciences

PPARα activation directly upregulates thrombomodulin in the diabetic retina

Akira Shiono et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

Calnexin mediates the maturation of GPI-anchors through ER retention

Xin-Yu Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Review Cell Biology

CircRNA Is a Rising Star in Researches of Ocular Diseases

Chengshou Zhang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

O- glycosylation can regulate the proliferation and migration of human retinal microvascular endothelial cells through ZFR in high glucose condition

Xindan Xing et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Pharmacology & Pharmacy

Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach

Chiara Bianca Maria Platania et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

ER stress response mediates diabetic microvascular complications

Himanshu Sankrityayan et al.

DRUG DISCOVERY TODAY (2019)

Article Medicine, Research & Experimental

Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema

Akrit Sodhi et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Biochemistry & Molecular Biology

Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution

Jernej Ule et al.

MOLECULAR CELL (2019)

Article Biochemistry & Molecular Biology

A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex

Alison Forrester et al.

EMBO JOURNAL (2019)

Article Endocrinology & Metabolism

Glucagon-like peptide-1 receptor expression in the human eye

Josephine B. Hebsgaard et al.

DIABETES OBESITY & METABOLISM (2018)

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Review Biochemistry & Molecular Biology

Regulation of alternative mRNA splicing: old players and new perspectives

Heidi Dvinge

FEBS LETTERS (2018)

Review Cell Biology

Alternative splicing as a regulator of development and tissue identity

Francisco E. Baralle et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Pharmacology & Pharmacy

NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes

Sachin V. Suryavanshi et al.

FRONTIERS IN PHARMACOLOGY (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis

Akram Safaei et al.

JOURNAL OF LASERS IN MEDICAL SCIENCES (2017)

Article Biochemistry & Molecular Biology

CELF1 preferentially binds to exon-intron boundary and regulates alternative splicing in HeLa cells

Heng Xia et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2017)

Article Medicine, General & Internal

Diabetic retinopathy

Tien Y. Wong et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Multidisciplinary Sciences

The human transcriptome across tissues and individuals

Marta Mele et al.

SCIENCE (2015)

Review Genetics & Heredity

Context-dependent control of alternative splicing by RNA-binding proteins

Xiang-Dong Fu et al.

NATURE REVIEWS GENETICS (2014)

Review Genetics & Heredity

Function of alternative splicing

Olga Kelemen et al.

Article Biotechnology & Applied Microbiology

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

Daehwan Kim et al.

GENOME BIOLOGY (2013)

Article Plant Sciences

Scarecrow Plays a Role in Establishing Kranz Anatomy in Maize Leaves

Thomas L. Slewinski et al.

PLANT AND CELL PHYSIOLOGY (2012)

Article Ophthalmology

The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy

Alistair J. Barber et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Identification of MicroRNA-93 as a Novel Regulator of Vascular Endothelial Growth Factor in Hyperglycemic Conditions

Jianyin Long et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Oncology

The pathobiology of splicing

Amanda J. Ward et al.

JOURNAL OF PATHOLOGY (2010)

Article Biochemical Research Methods

A global test for groups of genes: testing association with a clinical outcome

JJ Goeman et al.

BIOINFORMATICS (2004)