期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 291, 期 24, 页码 12547-12555出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R115.711507
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/L007959/1]
- Imperial College Antimicrobial Research Collaborative (ARC) Early Career Research Fellowship
- Biotechnology and Biological Sciences Research Council [BB/L007959/1] Funding Source: researchfish
- BBSRC [BB/L007959/1] Funding Source: UKRI
- MRC [MR/J006874/1] Funding Source: UKRI
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date compendium of c-di-GMP pathways connected to biofilm formation, biofilm-associated motilities, and other functionalities in the ubiquitous and opportunistic human pathogen Pseudomonas aeruginosa. This bacterium is frequently adopted as a model organism to study bacterial biofilm formation. Importantly, its versatility and adaptation capabilities are linked with a broad range of complex regulatory networks, including a large set of genes involved in c-di-GMP biosynthesis, degradation, and transmission.
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