期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 11, 期 11, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.122.025295
关键词
cMyBP-C; diastolic dysfunction; S-glutathionylation
资金
- National Institutes of Health [R01 HL104025, R01 HL106592, UL1TR001420, P40OD010965]
This study found that circulating S-glutathionylated cMyBP-C was elevated in humans, monkeys, and mice with diastolic dysfunction (DD), suggesting that it may serve as a novel biomarker for the presence of DD.
Background cMyBP-C (Cardiac myosin binding protein-C) regulates cardiac contraction and relaxation. Previously, we demonstrated that elevated myocardial S-glutathionylation of cMyBP-C correlates with diastolic dysfunction (DD) in animal models. In this study, we tested whether circulating S-glutathionylated cMyBP-C would be a biomarker for DD. Methods and Results Humans, African Green monkeys, and mice had DD determined by echocardiography. Blood samples were acquired and analyzed for S-glutathionylated cMyBP-C by immunoprecipitation. Circulating S-glutathionylated cMyBP-C in human participants with DD (n=24) was elevated (1.46 +/- 0.13-fold, P=0.014) when compared with the non-DD controls (n=13). Similarly, circulating S-glutathionylated cMyBP-C was upregulated by 2.13 +/- 0.47-fold (P=0.047) in DD monkeys (n=6), and by 1.49 (1.22-2.06)-fold (P=0.031) in DD mice (n=5) compared with the respective non-DD controls. Circulating S-glutathionylated cMyBP-C was positively correlated with DD in humans. Conclusions Circulating S-glutathionylated cMyBP-C was elevated in humans, monkeys, and mice with DD. S-glutathionylated cMyBP-C may represent a novel biomarker for the presence of DD.
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