期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 11, 期 9, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.121.022589
关键词
diet; preeclampsia; pregnancy
资金
- March of Dimes PERI grants [20-FY02-56, 21-FY07-605]
- National Institutes of Health [R21ES011666, 2R01HD041702, R21HD066471, R01HD086013, R01HD098232, R01 ES031272, R01ES031521]
- Health Resources and Services Administration of the US Department of Health and Human Services [UJ2MC31074]
- National Heart, Lung, and Blood Institute [T32HL007024]
- Lou and Nancy Grasmick Research Fellowship
- Marie-Josee and Henry R. Kravis Endowed Fellowship
- American Heart Association [827990]
- Amato Fund for Women's Cardiovascular Health at Johns Hopkins
- National Heart, Lung, and Blood Institute of the National Institutes of Health [K01HL141589]
This study found that self-reported higher adherence to a Mediterranean-style diet is associated with lower preeclampsia odds, and the benefit of this diet is present among Black women as well.
Background Preeclampsia is a major cause of maternal and fetal morbidity and mortality. Given its large public health burden, there is a need to identify modifiable factors that can be targeted for preeclampsia prevention. In this study, we examined whether a Mediterranean-style diet is protective for preeclampsia in a large cohort of racially and ethnically diverse, urban, low-income women. Methods and Results We used data from the Boston Birth Cohort. Maternal sociodemographic and dietary data were obtained via interview and food frequency questionnaire within 24 to 72 hours postpartum, respectively. Additional clinical information, including physician diagnoses of preexisting conditions and preeclampsia, were extracted from medical records. We derived a Mediterranean-style diet score from the food frequency questionnaire and performed logistic regression to examine the association of the Mediterranean-style diet score with preeclampsia. Of 8507 women in the sample, 848 developed preeclampsia. 47% were Black, 28% were Hispanic, and the remaining were White/Other. After multivariable adjustment, greatest adherence with MSD was associated with lower preeclampsia odds (adjusted odds ratio comparing tertile 3 to tertile 1, 0.78; 95% CI, 0.64-0.96). A subgroup analysis of Black women demonstrated a similar benefit with an adjusted odds ratio comparing tertile 3 to tertile 1 of 0.74 (95% CI, 0.76-0.96). Conclusions Self-report of higher adherence to a Mediterranean-style diet is associated with lower preeclampsia odds, and benefit of this diet is present among Black women as well.
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