期刊
FRONTIERS IN PLANT SCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2022.885625
关键词
anti-virulence; immune-priming; type III secretion system (TT3S); resveratrol oligomers; stilbene
资金
- National Research Foundation of Korea [NRF-2021R1A6A3A01086358]
- Korea University Grant [K2021521, K2106871]
- Korea University Insung Research Grant [PJ015871032021]
- Rural Development Administration (RDA), Republic of Korea [PJ015871032021] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Antibiotic resistance is becoming more common in the environment, necessitating the search for alternative strategies for disease treatment and prevention. Modulating bacterial virulence or enhancing plant innate immunity can be a promising drug target. Plant-produced natural products such as resveratrol oligomers have the potential to regulate bacterial virulence and plant immunity.
Antibiotic resistance has become increasingly prevalent in the environment. Many alternative strategies have been proposed for the treatment and prevention of diverse diseases in agriculture. Among them, the modulation of bacterial virulence to bypass antibiotic resistance or boost plant innate immunity can be considered a promising drug target. Plant-produced natural products offer a broad spectrum of stereochemistry and a wide range of pharmacophores, providing a great diversity of biological activities. Here, we present a perspective on the putative role of plant-produced resveratrol oligomers as anti-virulence and plant-immune priming agents for efficient disease management. Resveratrol oligomers can decrease (1) bacterial motility directly and (2) indirectly by attenuating the bacterial type III secretion system (TT3S). They induce enhanced local immune responses mediated by two-layered plant innate immunity, demonstrating (3) a putative plant immune priming role.
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