Emergence of a High-Risk Klebsiella michiganensis Clone Disseminating Carbapenemase Genes

Review Microbiology

Klebsiella oxytoca Complex: Update on Taxonomy, Antimicrobial Resistance, and Virulence

Jing Yang et al.

Summary: Klebsiella oxytoca is a complex of nine species that can cause various infections and is increasingly becoming resistant to antibiotics, posing a potential threat to human health.

CLINICAL MICROBIOLOGY REVIEWS (2022)

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Article Biology

Translational demand is not a major source of plasmid-associated fitness costs

Jeronimo Rodriguez-Beltran et al.

Summary: Limiting translation efficiency does not increase the fitness costs of plasmids, suggesting that ribosomal paucity is not a major driver of plasmid fitness costs.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2022)

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Article Microbiology

Phenotypic and Molecular Characterization of Commensal, Community-Acquired and Nosocomial Klebsiella spp.

Marta Gomez et al.

Summary: The human microbiota may serve as a potential reservoir for infection, with commensal Klebsiella strains exhibiting virulence traits comparable to infective isolates. A commensal K. pneumoniae strain showed inhibitory activity against multidrug-resistant Klebsiella isolates.

MICROORGANISMS (2021)

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Article Microbiology

Genotypic Characterization of Clinical Klebsiella spp. Isolates Collected From Patients With Suspected Community-Onset Sepsis, Sweden

Patricia Saxenborn et al.

Summary: Characterization of Klebsiella spp. in community-onset infections revealed high diversity and traits through whole-genome sequencing. Misidentifications of other species than K. pneumoniae are more common than previously described due to conventional microbiological methods. High rates of genotypic multidrug resistance were observed within the K. pneumoniae complex, highlighting the importance of using high-resolution genotypic methods for clinical isolates identification.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Infectious Diseases

First report of a blaVIM-1 metallo-β-lactamase-possessing Klebsiella michiganensis

Edgar I. Campos-Madueno et al.

Summary: This study characterized a clinical isolate of K. michiganensis, BD-50-Km, carrying bla VIM-1 gene associated with a rare class 1 integron. The strain belongs to a novel ST342 and core-genome analysis indicated it is not closely related to other reported K. michiganensis strains. The spread of plasmid-mediated VIM carbapenemases in this emerging pathogen poses an additional threat to current therapeutic options.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

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Article Genetics & Heredity

Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study

Aline Cuenod et al.

Summary: This study analyzed a diverse selection of Klebsiella spp. isolates from various healthcare institutions, identifying group and species-specific differences in antibiotic resistance and pathogenicity. Using species-specific marker masses, eight Klebsiella species can be distinguished using MALDI-TOF MS. Klebsiella oxytoca group isolates were less likely to be resistant to 4th-generation cephalosporins compared to Klebsiella pneumoniae group isolates, and were more associated with invasive infections.

GENOME MEDICINE (2021)

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Article Microbiology

Rapid Detection of New Delhi Metallo-β-Lactamase Gene Using Recombinase-Aided Amplification Directly on Clinical Samples From Children

Yanling Feng et al.

Summary: The New Delhi metallo-beta-lactamase (NDM) gene confers resistance to most beta-lactam antibiotics, making it crucial to detect this gene in children's clinical samples. The use of the recombinase-aided amplification (RAA) assay successfully identified bla(NDM) genes in children's stool samples, with some samples also testing positive for carbapenem-resistant bacteria. The presence of bla(NDM) and multidrug resistance genes poses significant challenges for pediatric treatment.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Infectious Diseases

Coexistence of two blaCTX-M-14 genes in a blaNDM-5-carrying multidrug-resistant Escherichia coli strain recovered from a bloodstream infection in China

Wei Zheng et al.

Summary: This study reports the first complete genome sequence of a multidrug-resistant Escherichia coli carrying bla (NDM-5) and two copies of bla (CTX-M-14) in China. The strain belongs to ST354 and contains six plasmids, including a 46161-bp IncX3 plasmid and a 96499-bp IncB plasmid. The closest relative of this E. coli isolate was found in Lebanon, differing by 162 cgMLST loci.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

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Article Genetics & Heredity

Improved molecular characterization of the Klebsiella oxytoca complex reveals the prevalence of the kleboxymycin biosynthetic gene cluster

Preetha Shibu et al.

Microbial Genomics (2021)

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Article Microbiology

Emergence of IncHI2 Plasmid-Harboring blaNDM-5 from Porcine Escherichia coli Isolates in Guangdong, China

Zhenbao Ma et al.

Summary: This study investigated the prevalence of bla(NDM-5) in pigs and analyzed the molecular characteristics of NDM-5-producing Escherichia coli isolates in Guangdong province, China. The results revealed that bla(NDM-5) was found in IncX3 and IncHI2 plasmids, with IncHI2 plasmids containing a typical IncHI2 plasmid backbone region and a multiresistance region (MRR). Continued surveillance for the dissemination of bla(NDM-5) among food-producing animals is necessary to understand and control carbapenem resistance.

PATHOGENS (2021)

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Review Infectious Diseases

The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases

Carola Mauri et al.

Summary: The combination of aztreonam + avibactam shows promise in treating infections caused by MBL-producing bacteria, especially Enterobacterales. Clinical resolution within 30 days was reported in 80% of infected patients, with a lower success rate for patients with bloodstream infections caused by Pseudomonas. Further research is needed to fully understand the effectiveness of this combination therapy.

ANTIBIOTICS-BASEL (2021)

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Article Immunology

Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana

Isaac Prah et al.

Summary: The study identified two Escherichia coli isolates producing OXA-181 from pediatric patients in Ghana, one with an IncX3 plasmid and the other with an IncFIC(FII) plasmid, which is a first in the African B4/H24RxC clade. The results highlight the importance of enhancing antimicrobial resistance surveillance.

EMERGING MICROBES & INFECTIONS (2021)

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Article Microbiology

Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit

Paul Chapman et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2020)

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Article Microbiology

Dissemination of the blaNDM-5 Gene via IncX3-Type Plasmid among Enterobacteriaceae in Children

Dongxing Tian et al.

MSPHERE (2020)

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Article Immunology

Multiple NDM-5-Expressing Escherichia Coli Isolates From an Immunocompromised Pediatric Host

Tim Flerlage et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

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Article Microbiology

Emergence of NDM-5-Producing Escherichia coli in a Teaching Hospital in Chongqing, China: IncF-Type Plasmids May Contribute to the Prevalence of blaNDM-5

Hua Zou et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Microbiology

Dissemination and Stability of the blaNDM-5-Carrying IncX3-Type Plasmid among Multiclonal Klebsiella pneumoniae Isolates

Wenjun Zhu et al.

MSPHERE (2020)

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Article Biochemistry & Molecular Biology

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

Ivica Letunic et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Multidisciplinary Sciences

Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance

Tanita Wein et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

Sudhir Kumar et al.

MOLECULAR BIOLOGY AND EVOLUTION (2018)

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Article Multidisciplinary Sciences

Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana

Alafate Ayibieke et al.

PLOS ONE (2018)

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Article Multidisciplinary Sciences

High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries

Chirag Jain et al.

NATURE COMMUNICATIONS (2018)

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Article Medicine, Research & Experimental

Antibiotic resistance in patients suffering from nosocomial infections in Besat Hospital

Sirous Faraji Hormozi et al.

EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (2018)

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Article Evolutionary Biology

Population Structure of Multidrug-Resistant Klebsiella oxytoca within Hospitals across the United Kingdom and Ireland Identifies Sharing of Virulence and Resistance Genes with K-pneumoniae

Danesh Moradigaravand et al.

GENOME BIOLOGY AND EVOLUTION (2017)

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Article Microbiology

Modified Carbapenem Inactivation Method for Phenotypic Detection of Carbapenemase Production among Enterobacteriaceae

Virginia M. Pierce et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2017)

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Review Microbiology

Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

Asad U. Khan et al.

BMC MICROBIOLOGY (2017)

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Review Infectious Diseases

A review of the pharmacokinetics and pharmacodynamics of aztreonam

Christopher Ramsey et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

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Letter Infectious Diseases

blaNDM-5-carrying IncX3 plasmid in Escherichia coli ST1284 isolated from raw milk collected in a dairy farm in Algeria

Lydia Yaici et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)

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Article Biochemical Research Methods

Roary: rapid large-scale prokaryote pan genome analysis

Andrew J. Page et al.

BIOINFORMATICS (2015)

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Article Biochemistry & Molecular Biology

IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies

Lam-Tung Nguyen et al.

MOLECULAR BIOLOGY AND EVOLUTION (2015)

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Article Biochemical Research Methods

Prokka: rapid prokaryotic genome annotation

Torsten Seemann

BIOINFORMATICS (2014)

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Article Biochemistry & Molecular Biology

The SEED and the Rapid Annotation of microbial genomes using Subsystems Technology (RAST)

Ross Overbeek et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Infectious Diseases

High cost burden and health consequences of antibiotic resistance: the price to pay

Sujith J. Chandy et al.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2014)

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Article Pharmacology & Pharmacy

Metallo-beta-lactamase structure and function

Timothy Palzkill

ANTIMICROBIAL THERAPEUTICS REVIEWS: THE BACTERIAL CELL WALL AS AN ANTIMICROBIAL TARGET (2013)

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Article Microbiology

A Novel Variant, NDM-5, of the New Delhi Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom

Michael Hornsey et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

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Article Biochemical Research Methods

Easyfig: a genome comparison visualizer

Mitchell J. Sullivan et al.

BIOINFORMATICS (2011)

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Article Biotechnology & Applied Microbiology

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons

Nabil-Fareed Alikhan et al.

BMC GENOMICS (2011)

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Article Microbiology

Role of type 1 and type 3 fimbriae in Klebsiella pneumoniae biofilm formation

Casper Schroll et al.

BMC MICROBIOLOGY (2010)

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Article Infectious Diseases

Development of a set of multiplex PCR assays for the detection of genes encoding important β-lactamases in Enterobacteriaceae

Caroline Dallenne et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2010)

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Article Microbiology

Six groups of the OXY β-lactamase evolved over millions of years in Klebsiella oxytoca

C Fevre et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

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Emergence of a High-Risk Klebsiella michiganensis Clone Disseminating Carbapenemase Genes

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