期刊
FRONTIERS IN MICROBIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.865001
关键词
oseltamivir; influenza virus; ILI; retrospective cohort study; clinical manifestation
类别
资金
- Clinical Key Project Youth Project in Peking University Third Hospital [BYSY2015017]
- National Major Science and Technology Project for the Control and Prevention of Major Infectious Diseases in China [2017ZX10103004]
- Haidian Prevention Medicine Association Funding [2017HDPMA04]
- Peking University Medicine Seed Fund for Interdisciplinary Research [BMU2018MX009]
This study conducted in northern China investigated the clinical efficacy of oseltamivir for patients with influenza virus infection. The results showed that oseltamivir therapy reduced the number of clinic visits for influenza-like illness patients, but did not have a significant effect on hospitalization frequency or the duration of fever and cough.
BackgroundOseltamivir resistance in influenza virus (IFV) has been of widespread concern. An increase in the frequency of viruses with reduced inhibition was observed. Whether oseltamivir is effective is uncertain. We conducted this study to understand the real-world situation in northern China and the clinical efficacy for patients with IFV infection after the use of oseltamivir. MethodsThe longitudinal study was performed on influenza-like illness (ILI) cases in a tertiary general hospital in Beijing, China during the flu season of 2018-2019. All ILI cases (>= 18 years) were recruited into the study. We analyzed the effect of the oseltamivir therapy on the number of clinic visits, hospitalization frequency, and the duration of fever and cough. ResultsA total of 689 ILI patients were recruited in this study with 355 in the oseltamivir therapy group and 334 in the supportive therapy group. Among the ILI patients, 388 patients were detected for IFV infection (364 IFV-A and 24 IFV-B) and divided into two groups with or without the oseltamivir therapy (302 vs. 86). There were no significant differences in the basic characteristics between the oseltamivir and supportive therapy groups in the ILI patients or in the IFV positive patients (all p < 0.05). After adjusting for the potential confounders, oseltamivir therapy reduced the times of clinic visits in the ILI and IFV positive patients (p = 0.043 and p = 0.011). No effectiveness with oseltamivir therapy was observed in the outcomes of hospitalization frequency, and the duration of fever and cough. ConclusionOseltamivir use may reduce the times of clinic visits. However, we did not observe the differences in the duration of fever, cough, and the frequency of hospitalization between oseltamivir therapy and supportive therapy.
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