期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.873304
关键词
virus-host interaction; enterovirus 71; hand; foot; and mouse disease; microRNA; long non-coding RNA; non-coding RNA
资金
- National Natural Science Foundation of China [31701162]
- Key Research and Developme n t Program of Anhui Province [202104a07020031]
This review summarizes recent advances in understanding the impact of non-coding RNAs on neurological diseases caused by the interaction between EV71 and the host, revealing the potential role of non-coding RNAs in the pathogenesis, diagnosis, and treatment of EV71-induced neurological complications.
Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth disease (HFMD). Studies have reported that EV71-induced infections including aseptic meningitis, acute flaccid paralysis, and even neurogenic pulmonary edema, can progress to severe neurological complications in infants, young children, and the immunosuppressed population. However, the mechanisms through which EV71 causes neurological diseases have not been fully explored. Non-coding RNAs (ncRNAs), are RNAs that do not code for proteins, play a key role in biological processes and disease development associated with EV71. In this review, we summarized recent advances concerning the impacts of ncRNAs on neurological diseases caused by interaction between EV71 and host, revealing the potential role of ncRNAs in pathogenesis, diagnosis and treatment of EV71-induced neurological complications.
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