4.7 Article

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.831186

关键词

major depressive disorder; gut microbiota; inflammation; Lachnospiraceae; Firmicutes

资金

  1. Natural Science Foundation Project of China [81901398, 81701360]
  2. Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0084, cstc2019jcyj-msxmX0025]
  3. Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202100420]
  4. Chongqing Yuzhong District Science & Technology Commission [20190115]

向作者/读者索取更多资源

This study identified potential biomarkers for objectively diagnosing major depressive disorder (MDD) and investigated the role of gut microbiota in depression onset. The results showed significant correlations between certain gut microbiota and inflammation-related factors with MDD severity. A panel of five inflammation-related factors effectively diagnosed MDD patients. These findings suggest the importance of Firmicutes and the potential of these factors as biomarkers for diagnosing MDD objectively.
ObjectiveAlthough many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression. MethodsMajor depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors. ResultsFinally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs. ConclusionsOur results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression via affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.

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