期刊
ELIFE
卷 11, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.74736
关键词
neuroscience; optogenetics; behavior; neural circuit; conditioned defense; innate fear; hypothalamus; Mouse
类别
This study reveals a new mechanism for experience-dependent, top-down control of innate defensive behaviors in animals, showing that the anterior hypothalamic nucleus is the key brain region involved, with the hippocampus transmitting information through this pathway to control memory and escape behaviors in prey.
Preys use their memory - where they sensed a predatory threat and whether a safe shelter is nearby - to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top -down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC -> AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top -down control of innate defensive behaviors.
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