Exposing the invader

Article Biology

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

Manutea C. Serrero et al.

Summary: This study identifies an interferon-inducible protein, MxB, that can sense herpesviral capsids and disassemble them, thereby restricting viral nuclear targeting and progeny capsid assembly, leading to enhanced innate immune responses.

ELIFE (2022)

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Article Virology

GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity

Linlin Xie et al.

Summary: The GTPase activity of the MxB protein plays a crucial role in restricting HIV-1 replication by influencing its nuclear localization, interaction with nucleoporins and HIV-1 capsids. The GTPase activity of MxB disrupts the association between nucleoporins and HIV-1 cores, leading to different mechanisms employed by wild-type MxB and GTPase activity defective MxB mutations in restricting HIV-1 replication.

VIROLOGICA SINICA (2021)

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Review Virology

Visualizing HIV-1 Capsid and Its Interactions with Antivirals and Host Factors

Morganne Wilbourne et al.

Summary: Significant progress has been made in understanding the construction and function of the HIV capsid in the past decade, largely due to advancements in structural techniques. The capsid is a complex structure comprised of proteins that play key roles in various stages of the viral life cycle. Studies have shown that interactions between the capsid and host factors can either promote or inhibit viral infectivity.

VIRUSES-BASEL (2021)

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Article Virology