期刊
CANCER LETTERS
卷 362, 期 1, 页码 8-14出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.03.019
关键词
Garcinia indica; Garcinol; Pharmacodynamics; Pharmacokinetics; Toxicology
类别
资金
- National Research Foundation of Singapore (Experimental Therapeutics Program) [R-713-001-011-271]
- National Medical Research Council of Singapore [NMRC/CSA/021/2010]
Garcinol is the main medicinal component of the dried fruit rind of Garcinia indica (Garcinia indica), which has traditionally been extensively used to treat gastric ailments and skin irritation. In vitro studies of garcinol revealed its potential therapeutic effects, such as its anti-oxidative, anti-inflammatory and anti-cancer properties. Similarly, in vivo studies in animal' models also demonstrated the efficacy of garcinol for the treatment of various inflammatory and cancerous conditions. Despite being well tolerated in preclinical studies, the toxicological profile of garcinol remains elusive. More importantly, systematic pharmacokinetics (PK) studies of garcinol to establish an appropriate route of administration and its effective concentration range under physiological conditions have not yet been performed. PK studies play an essential role in translating the preclinical findings of garcinol from cell line models and animal species to humans, thereby facilitating dose selectiori, the characterization of the therapeutic index, identification of a metabolic pathway, and the determination of garcinol's potency and tolerability. This paper reviews the current studies of garcinol as a potential anti-oxidant, anti-inflammatory and anti-cancer agent and highlights the importance of performing preclinical PK and toxicological studies on garcinol for its development pipeline. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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