期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200199
关键词
Biomass; Fluoride; Furfural; Iridium; Silicon
资金
- [951996]
Here we report a directed catalytic reaction for furfuryl imines, which allows access to versatile synthetic platforms. The reaction utilizes imines as directing groups and trialkylsilanes or bis(trimethylsilyl)methylsilane as silylating agents, in the presence of a hydride scavenger. Subsequently, fluoride-mediated activation strategies are applied to achieve a wide range of transformations and obtain high yields of products.
Herein we report directed iridium-catalyzed C3-H silylation of furfuryl imines, which grants access to versatile synthetic platforms. This transformation was developed on furfuryl derivatives, using imines as directing groups, and trialkylsilanes or bis(trimethylsilyl)methylsilane as silylating agents, in the presence of a hydride scavenger. Subsequently, fluoride-mediated activation strategies were applied to the C3-SiMe(OSiMe3)(2) furfural derivatives to achieve a wide range of transformations of the C3-Si bond. Arylation, alkenylation, alkynylation, allylation and alkylation, as well as halogenation and trifluoromethylation were achieved in modest to high yields. A variety of high value-added products were thus easily obtained from the same common C3-silylated furfural-based platform.
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